Photoacoustic mammography: initial clinical results

Abstract

It is suggested that PAM can image tumor vascularity and oxygenation, which may be useful for diagnosis and characterization of breast cancer.

Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

“…Another group, Kitai et al (65), used a photoacoustic imaging system (Canon, Tokyo, Japan; technology licensed from OptoSonics, Oriental, NC), in which the patient lies in a prone position on a table with the breast suspended through a rectangular aperture (17 cm 3 18 cm) and mildly compressed between two plates craniocaudally beneath the table (Fig 4). Laser light is delivered onto the breast through both plates while the detector is coupled to the caudal plate.…”

Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images

“…There have been many theoretical analyses and imaging studies of mammographic phantoms using PAT, and several preliminary reports have used these approaches for human breast cancer diagnosis. [10][11][12][13][14][15][16] Kruger et al 10 used a photoacoustic mammography (PAM) system with a hemispherical detector array to obtain breast images from four healthy female volunteers. Although the vascular networks were apparently clearly imaged, no morphological information could be obtained using this system.…”

“…The PAM system used by Manohar et al 13 consisted of a flat, static detector array and a light delivery system illuminated from the cranial direction. Kitai et al 16 also presented clinical results obtained using a dual-illumination-mode PAM prototype developed by our group that has a flat scanning detector and a light delivery system from both the cranial and caudal directions; hereafter, this is referred to as PAM-01. These four reports demonstrated the ability of a PAM system to detect breast cancer lesions compared with MMG and/or MRI.…”

Analog Front-End Circuitry in Piezoelectric and Microphone Detection of Photoacoustic Signals

“…Piezoelectric transducers are used mainly in photoacoustics of liquids [19][20][21][22] and solids for which the forms allow for direct contact with the transducer [23][24][25][26]-e.g., semiconductor structures [25,26]. They are also commonly used in medical and imaging applications [27,28], as well as for the study of nanoparticle suspensions [29,30]. Microphones are applied mainly in photoacoustic investigations of gases [1,2,[31][32][33][34] and such solids in which piezoelectric detection would be difficult-e.g., powders [35,36].…”