Photoacoustic Impulse Response of Lipid-Coated Ultrasound Contrast Agents

Daeichin, Verya; Inzunza-Ibarra, Marco A.; Lum, Jordan S.; Borden, Mark A.; Murray, Todd W.

doi:10.1109/tuffc.2021.3052140

Cited by 3 publications

(8 citation statements)

References 26 publications

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“…In contrast to previous studies ( e.g. in red van der Meer et al , 42 in green Daeichin et al 51 ), no dependence on the bubble size is found.…”

Section: Resultscontrasting

confidence: 99%

“…3(b), matches well the measurements carried out with the aforementioned laser scattering techniques (see e.g. Daeichin et al 51 ).…”

Section: Shell Dilatational Viscosity Estimationsupporting

confidence: 88%

“…However, our shell viscosity estimates contradict previous studies that reported a smaller scatter and an upward trend in shell viscosity as the bubble equilibrium radius increases, albeit with varying rates across studies. 36–40,42,45–47,50,51 We believe that these divergent results are an artifact caused by the measurement techniques adopted. In the next sections, we present arguments supporting our hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…Most of studies which found the upward trend with the bubble equilibrium radius have estimated the shell viscosity by analysing the bubble response in the frequency domain, [36][37][38]42,45,50,51 adopting the ''bubble spectroscopy'' technique introduced by van der Meer et al 42 or an equivalent of it for acoustic attenuation measurements. 36,37 The bubble spectroscopy method propounds to estimate the shell viscosity from the half-energy bandwidth of the microbubble frequency response treating the microbubble as a linear harmonic oscillator.…”

Section: Bubble Spectroscopy: Overestimating the Frequency Response B...mentioning

confidence: 99%

“…A side laser scattering system was used by Tu et al 46,47 to characterise the shell properties of commercial phospholipidcoated microbubbles by measuring their response to an ultrasound pulse. The sensitivity of this technique has been further improved by employing a forward laser-scattering system that enabled Lum et al 48 to measure the decaying free oscillations and Lum et al, 49 Supponen et al 50 and Daeichin et al 51 to retrieve the frequency response of single bubbles set into smallamplitude oscillations via photoacoustic forcing. Such small oscillations (few tens of nanometers) simplify the characterisation, as the absence of nonlinear effects allows the use of linear models.…”

Section: Introductionmentioning

confidence: 99%

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Shell viscosity estimation of lipid-coated microbubbles

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2023

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“…In contrast to previous studies ( e.g. in red van der Meer et al , 42 in green Daeichin et al 51 ), no dependence on the bubble size is found.…”

Section: Resultscontrasting

confidence: 99%

“…3(b), matches well the measurements carried out with the aforementioned laser scattering techniques (see e.g. Daeichin et al 51 ).…”

Section: Shell Dilatational Viscosity Estimationsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Bubble Spectroscopy: Overestimating the Frequency Response B...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Shell viscosity estimation of lipid-coated microbubbles

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Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery

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Single-shot attenuation coefficient estimation for ultrasound contrast agents

et al. 2022

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Ultrasound contrast agents (UCAs) have broadened the scope of ultrasound imaging and therapeutic applications. One of the parameters of interest when measuring the response of UCAs to ultrasound is their frequency-dependent attenuation coefficient. The estimation of this parameter is relevant for sensing and therapeutic applications, as well as for obtaining the viscoelastic properties of the UCA’s shell. The current practice to obtain this coefficient relies on experimental measurements made both in the presence and absence of UCAs in a target medium. Not only is the microbubble-free reference measurement time-consuming, but it may also not always be feasible for in vivo applications due to lack of an appropriate reflector. To overcome these challenges, we present here a novel approach which estimates the UCA’s attenuation spectra directly from pulse-echo measurements made in the underlying UCA medium, without any reference measurement. Furthermore, despite the non-linear frequency dependency of the UCA’s attenuation profile, our approach can still benefit from a fast linear least-squares based estimation scheme, providing attenuation estimates in a single-shot, which is desirable for implementation in real-time systems. We provide an investigative study, testing the estimator’s performance on various simulated realistic attenuation profiles obtained by varying the shell parameters and the UCA’s size distribution. In all cases, the estimated attenuation profiles were in good agreement with the true ones, with a relative error < 10%. Evaluation on experimental in vitro data shows a relative error < 15%, which further highlights the potential of our approach for fast and accurate UCA’s attenuation estimation.

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Photoacoustic Impulse Response of Lipid-Coated Ultrasound Contrast Agents

Cited by 3 publications

References 26 publications

Shell viscosity estimation of lipid-coated microbubbles

Shell viscosity estimation of lipid-coated microbubbles

Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery

Single-shot attenuation coefficient estimation for ultrasound contrast agents

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