Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery

Shakya, Gazendra; Cattaneo, Marco; Guerriero, Giulia; Prasanna, Anunay; Fiorini, Samuele; Supponen, Outi

doi:10.1016/j.addr.2023.115178

Advanced Drug Delivery Reviews

2024

DOI: 10.1016/j.addr.2023.115178

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Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery

Gazendra Shakya,

Marco Cattaneo,

Giulia Guerriero

et al.

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2024

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Cited by 8 publications

References 350 publications

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Dual‐Functional Nanodroplet for Tumor Vasculature Ultrasound Imaging and Tumor Immunosuppressive Microenvironment Remodeling

Liang,

Zhang,

Wang

et al. 2024

Adv Healthcare Materials

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Accurately evaluating tumor neoangiogenesis and conducting precise interventions toward an immune‐favorable microenvironment are of significant clinical importance. In this study, a novel nanodroplet termed as the nanodroplet‐based ultrasound contrast agent and therapeutic (NDsUCA/Tx) is designed for ultrasound imaging and precise interventions of tumor neoangiogenesis. Briefly, the NDsUCA/Tx shell is constructed from an engineered CMs containing the tumor antigen, vascular endothelial growth factor receptor 1 (VEGFR1) extracellular domain 2–3, and CD93 ligand multimerin 2. The core is composed of perfluorohexane and the immune adjuvant R848. After injection, NDsUCA/Tx is found to be enriched in the tumor vasculature with high expression of CD93. When triggered by ultrasound, the perfluorohexane in NDsUCA/Tx underwent acoustic droplet vaporization and generated an enhanced ultrasound signal. Some microbubbles exploded and the resultant debris (with tumor antigen and R848) together with the adsorbed VEGF are taken up by nearby cells. This cleared the local VEGF for vascular normalization, and also served as a vaccine to activate the immune response. Using a syngeneic mouse model, the satisfactory performance of NDsUCA/Tx in tumor vasculature imaging and immune activation is confirmed. Thus, a multifunctional NDsUCA/Tx is successfully developed for molecular imaging of tumor neoangiogenesis and precise remodeling of the tumor microenvironment.

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Dual‐Functional Nanodroplet for Tumor Vasculature Ultrasound Imaging and Tumor Immunosuppressive Microenvironment Remodeling

Liang,

Zhang,

Wang

et al. 2024

Adv Healthcare Materials

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Advances in microbubble-assisted ultrasound-guided gene therapy: Mechanisms and applications

Tie,

Zhang,

et al. 2024

Sci. China Mater.

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A Review of the Accuracy of Direct Numerical Simulation Tools for the Simulation of Non-Spherical Bubble Collapses

Saini,

Prouvost,

Popinet

et al. 2024

J Indian Inst Sci

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Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery

Cited by 8 publications

References 350 publications

Dual‐Functional Nanodroplet for Tumor Vasculature Ultrasound Imaging and Tumor Immunosuppressive Microenvironment Remodeling

Dual‐Functional Nanodroplet for Tumor Vasculature Ultrasound Imaging and Tumor Immunosuppressive Microenvironment Remodeling

Advances in microbubble-assisted ultrasound-guided gene therapy: Mechanisms and applications

A Review of the Accuracy of Direct Numerical Simulation Tools for the Simulation of Non-Spherical Bubble Collapses

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