Photoacoustic imaging of breast microcalcifications: A validation study with 3‐dimensional ex vivo data and spectrophotometric measurement

Abstract

This paper investigates whether photoacoustic imaging (PAI) can provide the visualization of microcalcifications in breast tissue. For this, the geometrical correlation between the 3-D PA images of breast microcalcifications within ex vivo specimens and the corresponding mammograms was ascertained. Also, the optical absorbance of the calcification compositions (i.e., hydroxyapatite and calcium oxalate) was measured and compared with the PA responses of the microcalcifications. The experimental results demonstrated that the PA images discriminated between the microcalcifications and the surrounding tissue, and their locations in PA images reasonably meshed with those of the microcalcifications appeared in the mammograms. Also, the change in PA signal amplitude along the laser wavelength agreed with the absorbance of hydroxyapatite associated with the relatively high potential of malignant cancers, but not calcium oxalate with only benign cases.

Thermal therapeutic method for selective treatment of deep-lying tissue by combining laser and high-intensity focused ultrasound energy

“…Another advantage in the proposed method is the use of photoacoustic imaging for monitoring the treatment process and temperature change in the treatment area [11,12]. This is because both the laser delivery system and the ultrasound transducer required for the proposed method can also be used for photoacoustic imaging given some minimal system modification.…”

A Pseudo-Dynamic Delay Calculation Using Optimal Zone Segmentation for Ultra-Compact Ultrasound Imaging Systems

“…Recently there have also been arising demands for, and investigations on, compact PA imaging systems [25][26][27], where an efficient beamforming solution is essential [28][29][30]. This may be needed for space-limiting clinical applications such as surgical and interventional guidance [24,[31][32][33]. Moreover, a compact system volume in PA imaging may extend its scientific efficacy.…”

“…Moreover, a compact system volume in PA imaging may extend its scientific efficacy. For example, it may enable an implantable and/or wearable PA neurosensing system for continuous monitoring, leading to successful translations of current neuroscientific findings and neuro-engineering innovations into practice [24][25][26][27][28][29][30][31][32][33][34][35][36].…”

Segmentation and Classification of Bi-Rads Medical Images with the Imaging Biomarkers According To Level of Detail

“…Images used in this research are images which can be found in the medical image data base defined in papers [19][20][21][22][23][24] as well as images which were available during the medical research at the Clinical Centre of Serbia. The degree of useful information makes the difference between the signals of original images and images treated after the segmentation.…”