Photo-thermal therapy of bladder cancer with Anti-EGFR antibody conjugated gold nanoparticles

Chen, Chieh Hsiao

doi:10.2741/4451

Cited by 21 publications

(19 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…49 Antibody-functionalised AuNPs have also been extensively studied for targeted PTT of a multitude of cancers. [50][51][52] Consistently, increased cytotoxicity and selective uptake of these targeted AuNPs is observed.…”

Section: Igg Antibodiessupporting

confidence: 56%

“…The conjugation of EGFR antibody fragments to AuNPs for PTT displayed cytotoxicity upon irradiation that varied with EGFR expression. 50 While the use of antibody fragments reduces the size of the targeting moiety attached to the AuNPs, these halfantibodies still display an immunogenic effect upon the body due to the presence of the Fc region. Antibody fragments known as Fab fragments have been developed to remove the Fc region, simultaneously reducing the size of the antibody and forming a non-immunogenic targeting moiety.…”

Section: Antibody Fragments and Nanobodiesmentioning

confidence: 99%

See 1 more Smart Citation

Active targeting of gold nanoparticles as cancer therapeutics

et al. 2020

View full text Add to dashboard Cite

show abstract

Section: Igg Antibodiessupporting

confidence: 56%

Section: Antibody Fragments and Nanobodiesmentioning

confidence: 99%

Active targeting of gold nanoparticles as cancer therapeutics

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Cetuximab conjugated gemcitabine loaded gold nanoparticles exerted a therapeutic effect against pancre atic adenocarcinoma xenografts [189]. Moreover, one should not forget mentioning an opportunity of using anti EGFR antibody conjugated gold nanoparticles for photo thermal destruction of cancer cells [190].…”

Section: The Use Of Egfr As a Delivery Systemmentioning

confidence: 99%

Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery

Rosenkranz

Slastnikova

2020

Biochemistry Moscow

View full text Add to dashboard Cite

Epidermal growth factor receptor (EGFR) is an integral surface protein mediating cellular response to a number of growth factors. Its overexpression and increased activation due to mutations is one of the most common traits of many types of cancer. Development and clinical use of the agents, which block EGFR activation, became a prime example of the personalized targeted medicine. However, despite the obvious success in this area, cancer cure remains unattainable in most cases. Because of that, as well as the result of the search for possible ways to overcome the difficulties of treatment, a huge number of new treatment methods relying on the use of EGFR overexpression and its changes to destroy cancer cells. Modern data on the structure, functioning, and intracellular transport of EGFR, its natural ligands, as well as signaling cascades triggered by the EGFR activation, peculiarities of the EGFR expression and activation in oncological disorders, as well as applied therapeutic approaches aimed at blocking EGFR signaling pathway are summarized and analyzed in this review. Approaches to the targeted delivery of various chemotherapeutic agents, radionuclides, immunotoxins, photosensitizers, as well as the prospects for gene therapy aimed at cancer cells with EGFR overexpression are reviewed in detail. It should be noted that increasing attention is being paid nowadays to the development of multifunctional systems, either carrying several different active agents, or possessing several environment-dependent transport functions. Potentials of the systems based on receptor-mediated endocytosis of EGFR and their possible advantages and limitations are discussed.

show abstract

“… 35 , 36 Nanoparticles conjugated with minibodies of anti-EGFR showed therapeutic benefits in orthotopic bladder tumor models. 37 …”

Section: Main Textmentioning

confidence: 99%

Endoscopic Molecular Imaging plus Photoimmunotherapy: A New Strategy for Monitoring and Treatment of Bladder Cancer

Yang

Liu

Yang

2020

Molecular Therapy - Oncolytics

View full text Add to dashboard Cite

Due to the high recurrence and progression rate of non-muscle invasive bladder cancer after transurethral resection of bladder tumor, some new optical imaging technologies have arisen as auxiliary imaging modes for white light cystoscopy to improve the detection rate of small or occult tumor lesions, such as photodynamic diagnosis, narrow-band imaging, and molecular imaging. White light cystoscopy is inadequate and imperfect for bladder cancer detection, and thus residual tumors or coexisting flat malignant lesions, especially carcinoma in situ , would be ignored during conventional resection. The bladder, a hollow organ with high compliance, provides an ideal closed operation darkroom for endoscopic molecular imaging free from interference of external light sources. Also, intravesical instillation of a molecular fluorescent tracer is simple and convenient before surgery through the urethra. Molecular fluorescent tracer has high sensitivity and specificity to tumor cells, and its mediated molecular imaging allows small or occult tumor lesion detection while minimizing false-positive results. Meanwhile, endoscopic molecular imaging provides a real-time and dynamic image during surgery, which helps urologists to perform high-quality and complete tumor resection through accurate judgment of tumor boundaries and depth of invasion. Photoimmunotherapy is a novel molecular targeted therapeutic pattern of photodynamic therapy that kills malignant cells selectively and minimizes the cytotoxicity to normal tissues. The combination of endoscopic molecular imaging and photoimmunotherapy used in initial treatment may avoid the need of repeat transurethral resection in strictly selected patients and improve oncological outcomes such as recurrence-free survival and overall survival after operation.

show abstract

Photo-thermal therapy of bladder cancer with Anti-EGFR antibody conjugated gold nanoparticles

Cited by 21 publications

References 26 publications

Active targeting of gold nanoparticles as cancer therapeutics

Active targeting of gold nanoparticles as cancer therapeutics

Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery

Endoscopic Molecular Imaging plus Photoimmunotherapy: A New Strategy for Monitoring and Treatment of Bladder Cancer

Contact Info

Product

Resources

About