Active targeting of gold nanoparticles as cancer therapeutics

Goddard, Zoë Rachael; Marín, María J.; Russell, David A.; Searcey, Mark

doi:10.1039/d0cs01121e

Cited by 170 publications

(163 citation statements)

References 142 publications

(178 reference statements)

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“…El Domany et al 88 described that biosynthesized AuNPs were more cytotoxic than chemically synthesized AuNPs in studies with PC-3, HCT116, and HepG2 tumor cells. Besides, the easy modification of the allows their association with other antitumor drugs and molecules that can target specifics cells, such as cancer cells 89 . Researchers have been reported the beneficial effects of the combination between anticancer agents and polyphenols 90,91 , as well as compounds found in BRP [92][93][94] .…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

Botteon

Silva

Ccana-Ccapatinta

et al. 2021

Sci Rep

141

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Gold nanoparticles (AuNPs) are highlighted due to their low toxicity, compatibility with the human body, high surface area to volume ratio, and surfaces that can be easily modified with ligands. Biosynthesis of AuNPs using plant extract is considered a simple, low-cost, and eco-friendly approach. Brazilian Red Propolis (BRP), a product of bees, exhibits anti-inflammatory, anti-tumor, antioxidant, and antimicrobial activities. Here, we described the biosynthesis of AuNPs using BRP extract (AuNPextract) and its fractions (AuNPhexane, AuNPdichloromethane, AuNPethyl acetate) and evaluated their structural properties and their potential against microorganisms and cancer cells. AuNPs showed a surface plasmon resonance (SPR) band at 535 nm. The sizes and morphologies were influenced by the BRP sample used in the reaction. FTIR and TGA revealed the involvement of bioactive compounds from BRP extract or its fractions in the synthesis and stabilization of AuNPs. AuNPdichloromethane and AuNPhexane exhibited antimicrobial activities against all strains tested, showing their efficacy as antimicrobial agents to treat infectious diseases. AuNPs showed dose-dependent cytotoxic activity both in T24 and PC-3 cells. AuNPdichloromethane and AuNPextract exhibited the highest in vitro cytotoxic effect. Also, the cytotoxicity of biogenic nanoparticles was induced by mechanisms associated with apoptosis. The results highlight a potential low-cost green method using Brazilian red propolis to synthesize AuNPs, which demonstrated significant biological properties.

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Section: Cytotoxic Activitymentioning

confidence: 99%

Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

Botteon

Silva

Ccana-Ccapatinta

et al. 2021

Sci Rep

141

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“…Many reports have demonstrated the impact of particle size, morphology, surface charge, functional surface modification, and different types of cells on cellular uptake of GNPs and their subcellular distribution [56][57][58]. Furthermore, various strategies have been established, exploiting the physiochemical properties of GNPs themselves (passive targeting) or employing active targeting moieties to ensure efficient intracellular delivery of GNPs to cancer cells [59,60]. In this study, the mode of cellular internalization and, subsequently, the interaction with nuclear material, were evaluated by utilizing a DAPI fluorescent dye ( Figure 5C,D).…”

Section: Gnps Cytotoxicity and Anticancer Activitymentioning

confidence: 99%

Synthesis of Gold Nanoparticles by Using Green Machinery: Characterization and In Vitro Toxicity

et al. 2021

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Green synthesis of gold nanoparticles (GNPs) with plant extracts has gained considerable interest in the field of biomedicine. Recently, the bioreduction nature of herbal extracts has helped to synthesize spherical GNPs of different potential from gold salt. In this study, a fast ecofriendly method was adopted for the synthesis of GNPs using fresh peel (aqueous) extracts of Benincasa hispida, which acted as reducing and stabilizing agents. The biosynthesized GNPs were characterized by UV–VIS and Fourier transform infrared spectroscopy, transmission electron microscopy (TEM), and dynamic light scattering. In addition, the in vitro antibacterial and anticancer activities of synthesized GNPs were investigated. The formation of gold nanoparticles was confirmed by the existence of a sharp absorption peak at 520 nm, corresponding to the surface plasmon resonance (SPR) band of the GNPs. TEM analysis revealed that the prepared GNPs were spherical in shape and had an average particle size of 22.18 ± 2 nm. Most importantly, the synthesized GNPs exhibited considerable antibacterial activity against different Gram-positive and Gram-negative bacteria. Furthermore, the biosynthesized GNPs exerted remarkable in vitro cytotoxicity against human cervical cancer cell line, while sparing normal human primary osteoblast cells. Such cytotoxic effect was attributed to the increased production of reactive oxygen species (ROS) that contributed to the damage of HeLa cells. Collectively, peel extracts of B. hispida can be efficiently used for the synthesis of GNPs, which can be adopted as a natural source of antimicrobial and anticancer agent.

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“…Development of nanotechnology techniques provides the possibility of using nanomaterials in medicine especially in the detection and treatment of cancer. Nanomaterials such as gold nanoparticles (GNPs) have high atomic number (Z = 79) and preferential mass energy absorption compared to soft tissues; thus present radiosensitizing properties and potentially improve tumor control, reduce the side effects and increase the patients survival when compared to radiotherapy alone [5,[7][8][9]. Additionally, GNPs are relatively easy to synthesize in a range of sizes, and have been shown to passively accumulate in tumors through their enhanced permeability and retention (EPR) effect [10].…”

Section: Introductionmentioning

confidence: 99%

Radiosensitization of breast cancer cells using AS1411 aptamer-conjugated gold nanoparticles

et al. 2021

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Background Gold nanoparticles (GNPs) have been used to sensitize cancer cells and enhance the absorbed dose delivered to such cells. Active targeting can provide specific effect and higher uptake of the GNPs in the tumor cells, while having small effect on healthy cells. The aim of this study was to assess the possible radiosensitiazation effect of GNPs conjugated with AS1411 aptamer (AS1411/GNPs) on cancer cells treated with 4 MeV electron beams. Materials and methods Cytotoxicity studies of the GNPs and AS1411/GNPs were carried out with MTT and MTS assay in different cancer cell lines of MCF-7, MDA-MB-231 and mammospheres of MCF-7 cells. Atomic absorption spectroscopy confirmed the cellular uptake of the gold particles. Radiosensitizing effect of the GNPs and AS1411/GNPs on the cancer cells was assessed by clonogenic assay. Result AS1411 aptamer increased the Au uptake in MCF-7 and MDA-MB-231 cells. Clonogenic survival data revealed that AS1411/GNPs at 12.5 mg/L could result in radiosensitization of the breast cancer cells and lead to a sensitizer enhancement ratio of 1.35 and 1.66 and 1.91 for MCf-7, MDA-MB-231 and mammosphere cells. Conclusion Gold nanoparticles delivery to the cancer cells was enhanced by AS1411 aptamer and led to enhanced radiation induced cancer cells death. The combination of our clonogenic assay and Au cell uptake results suggested that AS1411 aptamer has enhanced the radiation-induced cell death by increasing Au uptake. This enhanced sensitization contributed to cancer stem cell-like cells to 4 MeV electron beams. This is particularly important for future preclinical testing to open a new insight for the treatment of cancers.

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Active targeting of gold nanoparticles as cancer therapeutics

Abstract: Gold nanoparticles are excellent delivery systems, but how can we get them where we want them to go?

Cited by 170 publications

References 142 publications

Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

Synthesis of Gold Nanoparticles by Using Green Machinery: Characterization and In Vitro Toxicity

Radiosensitization of breast cancer cells using AS1411 aptamer-conjugated gold nanoparticles

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