Photo-responsive, biocompatible polymeric micelles self-assembled from hyperbranched polyphosphate-based polymers

Chen, Chaojian; Liu, Gongyan; Liu, Xiangsheng; Pang, Shaopeng; Zhu, Congshan; Lv, Liping; Ji, Jian

doi:10.1039/c1py00094b

Cited by 113 publications

(78 citation statements)

References 67 publications

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“…Hydrophobic dye NR was chosen as a fluorescence probe to be loaded into the micelles, which was based on the fact that the very low solubility of NR in water led to a low fluorescence emission, but when solubilized in hydrophobic micelle core, the fluorescence emission become much more intense and blue shifted. [11,47,48] It can be seen from Fig. 3(a) and (c) that NR exhibited a relative low fluorescence intensity at low concentrations, indicating that the NR molecules were in water and few micelles were present.…”

Section: Synthesis and Characterization Of Block Copolymersmentioning

confidence: 94%

Photo‐responsive amphiphilic poly(α‐hydroxy acids) with pendent o‐nitrobenzyl ester constructed via copper‐catalyzed azide‐alkyne cycloaddition reaction

Liu

Niu

et al. 2015

Polymers for Advanced Techs

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Photo-responsive block copolymer mPEG-b-poly(Tyr)-g-NB was prepared by introduction of o-nitrobenzyl ester group into the side chain of amphiphilic poly(ethylene glycol)-b-poly(α-hydroxy acids) (mPEG-b-poly(Tyr)) containing pendent alkynyl group via copper-catalyzed azide-alkyne cycloaddition reaction. The amphiphilic mPEG-bpoly(Tyr) was synthesized via the ring-opening polymerization of O-carboxyanhydrides, with monomethoxy poly (ethylene glycol) (mPEG) as macroinitiator. The molecular structure, self-assembly, and photo-controlled release of the obtained mPEG-b-poly(Tyr)-g-NB were thoroughly investigated. mPEG-b-poly(Tyr)-g-NB could self-assemble into spherical micelles in water and showed disassembly under UV light irradiation, which was demonstrated by means of UV-vis spectroscopy, scan electron microscopes, and dynamic light scattering measurement. Fluorescence emission measurements demonstrated that Nile red, encapsulated by micelles, can be released upon UV irradiation. This study provides a convenient way to construct smart poly(α-hydroxy acids)-based nanocarriers for controlled release of hydrophobic drugs.

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Section: Synthesis and Characterization Of Block Copolymersmentioning

confidence: 94%

Photo‐responsive amphiphilic poly(α‐hydroxy acids) with pendent o‐nitrobenzyl ester constructed via copper‐catalyzed azide‐alkyne cycloaddition reaction

Liu

Niu

et al. 2015

Polymers for Advanced Techs

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“…170 This hydrophobic molecule changes into hydrophilic 3-indene carboxylic acid through a Wolf rearrangement reaction. 171 DNQ has been widely used in many nanocarriers in order to deliver different cargos. For example Wang and coworkers synthesized a triple-stimulus responsive copolymer consisting of DNQ as a chromophore which was modulated by pH, light, and temperature.…”

Section: Different Stimuli-responsive Mnpsmentioning

confidence: 99%

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

et al. 2016

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New achievements in the realm of nanoscience and innovative techniques of nanomedicine have moved micro/nanoparticles (MNPs) to the point of becoming actually useful for practical applications in the near future. Various differences between the extracellular and intracellular environments of cancerous and normal cells and the particular characteristics of tumors such as physicochemical properties, neovasculature, elasticity, surface electrical charge, and pH have motivated the design and fabrication of inventive “smart” MNPs for stimulus-responsive controlled drug release. These novel MNPs can be tailored to be responsive to pH variations, redox potential, enzymatic activation, thermal gradients, magnetic fields, light, and ultrasound (US), or can even be responsive to dual or multi-combinations of different stimuli. This unparalleled capability has increased their importance as site-specific controlled drug delivery systems (DDSs) and has encouraged their rapid development in recent years. An in-depth understanding of the underlying mechanisms of these DDS approaches is expected to further contribute to this groundbreaking field of nanomedicine. Smart nanocarriers in the form of MNPs that can be triggered by internal or external stimulus are summarized and discussed in the present review, including pH-sensitive peptides and polymers, redox-responsive micelles and nanogels, thermo- or magnetic-responsive nanoparticles (NPs), mechanical- or electrical-responsive MNPs, light or ultrasound-sensitive particles, and multi-responsive MNPs including dual stimuli-sensitive nanosheets of graphene. This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.

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“…Thus, NIR-responsive systems are promising platforms for clinical applications. 448−450 Several studies have demonstrated that upon NIR irradiation, 451 AuNPs incorporated in the wall of the polymer-based delivery container can convert light into heat through a series of photophysical processes. The heat can directly destroy cancer cells or facilitate disruption of thermoresponsive NPs, resulting in the release of encapsulated drugs.…”

Section: In Vivo Treatment (“Particle-based Delivery”)mentioning

confidence: 99%

Diverse Applications of Nanomedicine

Pelaz¹,

et al. 2017

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The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.

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Photo-responsive, biocompatible polymeric micelles self-assembled from hyperbranched polyphosphate-based polymers

Cited by 113 publications

References 67 publications

Photo‐responsive amphiphilic poly(α‐hydroxy acids) with pendent o‐nitrobenzyl ester constructed via copper‐catalyzed azide‐alkyne cycloaddition reaction

Photo‐responsive amphiphilic poly(α‐hydroxy acids) with pendent o‐nitrobenzyl ester constructed via copper‐catalyzed azide‐alkyne cycloaddition reaction

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Diverse Applications of Nanomedicine

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