Photo‐responsive amphiphilic poly(<i>α</i>‐hydroxy acids) with pendent <i>o</i>‐nitrobenzyl ester constructed via copper‐catalyzed azide‐alkyne cycloaddition reaction

Liu, Xiangyu; He, Jian; Niu, Yile; Li, Yefei; Ding, Hongyan; Xia, Xinnian; Lu, Yanbing; Xu, Weijian

doi:10.1002/pat.3472

Cited by 20 publications

(18 citation statements)

References 54 publications

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“…(B)]. Both the change on morphology and size of the nanoparticles were mostly attributed to the trans ‐ cis isomerization of the Azo moieties, which resulted in an increase in dipole moment . Though the polarity of Azo moieties side chain on the hydrophobic block shifted the hydrophilic–hydrophobic balance, it was not enough to destabilize micelles.…”

Section: Resultsmentioning

confidence: 99%

Light and pH dual‐sensitive biodegradable polymeric nanoparticles for controlled release of cargos

Xia

Zeng

Ding

et al. 2017

J. Polym. Sci. Part A: Polym. Chem.

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In this article, a light and pH dual‐sensitive block copolymer PEG‐b‐poly(MPC‐Azo/DEA) was facilely prepared for the first time by azide‐alkyne click chemistry between amphiphilic block copolymer bearing pendant alkynyl group poly(ethylene glycol)‐poly(5‐methyl‐5‐propargylxycarbonyl‐1,3‐dioxane‐2‐one) (PEG‐b‐poly(MPC)) and two azide‐containing compounds azobenzene derivative (Azo‐N3) and 2‐azido‐1‐ethyl‐diethylamine (DEA‐N3). Light response of the polymeric nanoparticles benefits from the azobenzene segments and pH responsiveness is attributed to DEA moieties. The prepared copolymer could self‐assemble into spherical micelle particles. The morphological changes of these particles in response to dual stimuli were investigated by UV/vis spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM). Nile Red (NR) was utilized as probe, and fluorescence spectroscopy was served as an evidence for the enhanced release of cargos from polymeric nanoparticles under combined stimulation. Anticancer drug, DOX was loaded into the nanoparticles and the loaded‐DOX could be released from these nanoparticles under dual stimuli. MTT assays further demonstrated that PEG‐b‐poly(MPC) and PEG‐b‐poly(MPC‐Azo/DEA) were of biocompatibility and low toxicity against HepG2 cells as well as SMCC‐7721 cells. More importantly, the prepared DOX‐loaded nanoparticles exhibited good anticancer ability for the two cells. The synthesized light and pH dual‐sensitive biodegradable polymeric nanoparticles were expected to be platforms for precisely controlled release of encapsulated molecules. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1773–1783

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Section: Resultsmentioning

confidence: 99%

Light and pH dual‐sensitive biodegradable polymeric nanoparticles for controlled release of cargos

Xia

Zeng

Ding

et al. 2017

J. Polym. Sci. Part A: Polym. Chem.

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“…A primary objective for many studies designing photochemically-triggered micelle drug-delivery systems has been to synthesize biocompatible materials for micelle fabrication [37][38][39]. For about the last 10 years, the goal has been to further enhance both the biocompatibility and utility of these systems by using nontoxic wavelengths of light that readily penetrate tissues [40].…”

Section: Micellesmentioning

confidence: 99%

Recent Advances in light-responsive on-demand drug-delivery Systems

2017

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The convergence of wearable sensors and personalized medicine enhance the ability to sense and control the drug composition and dosage, as well as location and timing of administration. To date, numerous stimuli-triggered smart drug-delivery systems have been developed to detect changes in light, pH, temperature, biomolecules, electric field, magnetic field, ultrasound and mechanical forces. This review examines the major advances within the last 5 years for the three most common light-responsive drug delivery-on-demand strategies: photochemical, photoisomerization and photothermal. Examples are highlighted to illustrate progress of each strategy in drug delivery applications, and key limitations are identified to motivate future research to advance this important field.

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“…Compared to photochromic units, polymers containing photocleavable units have an irreversible light‐responsive behavior, which involves the cleavage of light‐responsive moiety into a more polar species via an irreversible transformation upon irradiation . O ‐nitrobenzyl ester (ONB) is one of the most important photocleavable molecules that undergo irreversible light‐responsive process . In general, UV light is used to initiate the photocleavage process; however, in some case, the light‐responsive groups can be broken by NIR light as well .…”

Section: Light‐responsive Nddssmentioning

confidence: 99%

Polymer-based drug delivery systems for cancer treatment

Guo

Wang

Xiao

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

112

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This review is focused on the chemical design and synthesis of polymer‐based drug delivery systems, in particular with stimuli‐responsive nanoplatforms for cancer treatment. We provide a brief description of the properties, synthesis and advantages of amphiphilic block copolymers, including polyether‐polyester and polyether‐polyanhydride. As for stimuli‐responsive polymers, we detail the recent innovative techniques for constructing smarter, more precise and optimally tuned nanocarriers that release drug in the disease site. This review is presented in the context of polymer science research, with special attention focused on the tailor‐made polymers containing specific chemical functionalities. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 3525–3550

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Photo‐responsive amphiphilic poly(α‐hydroxy acids) with pendent o‐nitrobenzyl ester constructed via copper‐catalyzed azide‐alkyne cycloaddition reaction

Cited by 20 publications

References 54 publications

Light and pH dual‐sensitive biodegradable polymeric nanoparticles for controlled release of cargos

Light and pH dual‐sensitive biodegradable polymeric nanoparticles for controlled release of cargos

Recent Advances in light-responsive on-demand drug-delivery Systems

Polymer-based drug delivery systems for cancer treatment

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