Recent Advances in light-responsive on-demand drug-delivery Systems

Linsley, Chase S.; Wu, Benjamin M.

doi:10.4155/tde-2016-0060

Cited by 191 publications

(157 citation statements)

References 111 publications

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“…Drug release can then occur via leakage from the nanocarrier or as a result of nanoparticle degradation. Accelerated drug release can also be triggered using particles or linkages that are sensitive to the acidic tumor microenvironment (Kanamala, Wilson, Yang, Palmer, & Wu, 2016), hypoxia (Thambi, Park, & Lee, 2016), light (Linsley & Wu, 2017), ultrasound (Boissenot, Bordat, Fattal, & Tsapis, 2016), or temperature (Mura, Nicolas, & Couvreur, 2013;Sánchez-Moreno, de Vicente, Nardecchia, Marchal, & Boulaiz, 2018). Rapid/triggered drug release can lead to a transient spike in the local concentration of drug and result in improved therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting

Liu

Jang

Issadore

et al. 2019

WIREs Nanomed Nanobiotechnol

128

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Drug delivery strategies aim to maximize a drug's therapeutic index by increasing the concentration of drug at target sites while minimizing delivery to off‐target tissues. Because biological tissues are minimally responsive to magnetic fields, there has been a great deal of interest in using magnetic nanoparticles in combination with applied magnetic fields to selectively control the accumulation and release of drug in target tissues while minimizing the impact on surrounding tissue. In particular, spatially variant magnetic fields have been used to encourage accumulation of drug‐loaded magnetic nanoparticles at target sites, while time‐variant magnetic fields have been used to induce drug release from thermally sensitive nanocarriers. In this review, we discuss nanoparticle formulations and approaches that have been developed for magnetic targeting and/or magnetically induced drug release, as well as ongoing challenges in using magnetism for therapeutic applications. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Section: Introductionmentioning

confidence: 99%

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting

Liu

Jang

Issadore

et al. 2019

WIREs Nanomed Nanobiotechnol

128

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“…Low oxygen concentration is a potent regulator of angiogenesis, driving sprouting of ECs toward the deficient tissue (Pugh and Ratcliffe, 2003;Ziyad and Iruela-Arispe, 2011;Viallard and Larrivée, 2017;Petrova et al, 2018) through hypoxia inducible factor-dependent increase of VEGF transcription (Liao and Johnson, 2007;Oladipupo et al, 2011). Recreating a hypoxic environment has been revealed to be useful for therapeutic angiogenesis in bone TE both in vitro and in vivo (Wu et al, 2012;Deng et al, 2019).…”

Section: Hypoxiamentioning

confidence: 99%

Angiogenesis in Tissue Engineering: As Nature Intended?

Mastrullo

Cathery

Velliou

et al. 2020

Front. Bioeng. Biotechnol.

127

109

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Despite the steady increase in the number of studies focusing on the development of tissue engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack of mature and functional vasculature greatly limits the size and complexity of vascular scaffold models. If tissue engineering aims to replace large portions of tissue with the intention of repairing significant defects, a more thorough understanding of the mechanisms and players regulating the angiogenic process is required in the field. This review will present the current material and technological advancements addressing the imperfect formation of mature blood vessels within tissue engineered structures.

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“…Photoswitches are a particularly attractive tool as the stimulus, light, can be applied with both temporal and spatial control and modified through light intensity, wavelength and irradiation time 25–27. As a result, there are a plethora of reports demonstrating the responsive behavior in the fields of drug delivery, 3D‐printing, sensing, microscopy and information technology 28–33. Current established photoresponsive materials consist of a chromophore that can convert a light input into a number of potential chemical outputs.…”

Section: Aqueous Stimuli‐responsive Materialsmentioning

confidence: 99%

Design Principles for Aqueous Interactive Materials: Lessons from Small Molecules and Stimuli‐Responsive Systems

et al. 2020

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Interactive materials are at the forefront of current materials research with few examples in the literature. Researchers are inspired by nature to develop materials that can modulate and adapt their behavior in accordance with their surroundings. Stimuli‐responsive systems have been developed over the past decades which, although often described as “smart,” lack the ability to act autonomously. Nevertheless, these systems attract attention on account of the resultant materials' ability to change their properties in a predicable manner. These materials find application in a plethora of areas including drug delivery, artificial muscles, etc. Stimuli‐responsive materials are serving as the precursors for next‐generation interactive materials. Interest in these systems has resulted in a library of well‐developed chemical motifs; however, there is a fundamental gap between stimuli‐responsive and interactive materials. In this perspective, current state‐of‐the‐art stimuli‐responsive materials are outlined with a specific emphasis on aqueous macroscopic interactive materials. Compartmentalization, critical for achieving interactivity, relies on hydrophobic, hydrophilic, supramolecular, and ionic interactions, which are commonly present in aqueous systems and enable complex self‐assembly processes. Relevant examples of aqueous interactive materials that do exist are given, and design principles to realize the next generation of materials with embedded autonomous function are suggested.

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Recent Advances in light-responsive on-demand drug-delivery Systems

Cited by 191 publications

References 111 publications

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting

Angiogenesis in Tissue Engineering: As Nature Intended?

Design Principles for Aqueous Interactive Materials: Lessons from Small Molecules and Stimuli‐Responsive Systems

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