Photo-induced synthesis glucose-responsive carriers for controlled release of insulin in vitro

Du, Xiangxiang; Jiang, Guohua; Li, Lei; Liu, Yongkun; Chen, Hua; Huang, Qin

doi:10.1007/s00396-015-3625-5

Cited by 17 publications

(5 citation statements)

References 31 publications

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“…Phenyl boronic acid (PBA) and its derivatives are known to form covalent hydrophilic glucose–PBA complexes with glucose from the uncharged trigonal planar to the negatively charged tetrahedral. The hydrophilic/hydrophobic balance shifts to a more hydrophobic nature with an increase in the particle size . As shown in Figure (A), with increasing concentration of glucose (0–8 mg/mL), the size of the micelles exhibited a near‐linear dependence on the glucose concentration.…”

Section: Resultsmentioning

confidence: 91%

Preparation of glucose‐sensitive and fluorescence micelles via a combination of photoinitiated polymerization and chemoenzymatic transesterification for the controlled release of insulin

Jiang²,

et al. 2015

J of Applied Polymer Sci

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Glucose-sensitive and fluorescence copolymer micelles were designed and prepared via a combination of photoinitiated polymerization and enzymatic transesterification. The water-soluble photoinitiator and emulsifier 2-oxooctanoic acid self-polymerized dimer molecules under UV irradiation were characterized by mass spectrometry. The fluorescence dye (9-anthracene alcohol) and biocompatible hydrophilic chains [poly(ethylene glycol)] were introduced to the polymer chains during the photopolymerization and enzymatic transesterification processes. The as-prepared copolymers were confirmed by 1 H-NMR spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, and dynamic light scattering. The resulting copolymers exhibited excellent glucose sensitivity and stability against protein. The optical fluorescence properties of the copolymer micelles were investigated with fluorescence spectrophotometry, fluorescence microscopy, and confocal laser scanning microscopy. Because of the amphiphilic feature, the micelles could be self-assembled and used to load insulin. The controlled release of insulin was evaluated and was triggered by glucose in vitro. This study provided a new strategy for fabricating functional carriers as self-regulated insulin-release systems. V C 2015Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43026.

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Section: Resultsmentioning

confidence: 91%

Preparation of glucose‐sensitive and fluorescence micelles via a combination of photoinitiated polymerization and chemoenzymatic transesterification for the controlled release of insulin

Jiang²,

et al. 2015

J of Applied Polymer Sci

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“…The development of glucose-sensitive materials such as thin films and gels is currently a focal subject in biomaterials science and technology because of their potential use in biosensors and drug delivery systems [27][28][29]. In this regard, it is interesting to study the response of (GOx/PBA-PAMAM) 10 film to glucose because glucose would be oxidized by GOx according to the reaction (Eq.…”

Section: Filmmentioning

confidence: 99%

Preparation of multilayer films consisting of glucose oxidase and poly(amidoamine) dendrimer and their stability

2015

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Multilayer films comprising of glucose oxidase (GOx) and phenylboronic acid-modified poly(amidoamine) dendrimer (PBA-PAMAM) were prepared and their pHand glucose-induced decomposition was studied. Multilayered GOx/PBA-PAMAM films were prepared through boronate ester linkages between PBA-PAMAM and carbohydrate chains of GOx. In contrast, preparation of multilayer film was unsuccessful when unmodified PAMAM was used in lieu of PBA-PAMAM, confirming an essential role of PBA residues in constructing multilayer films. The ten-layered (GOx/PBA-PAMAM) 10 film was stable in aqueous solutions of pH 8.5, whereas the multilayer film decomposed in neutral and acidic media as a result of cleavage of the boronate ester bond. The pH threshold for the film decomposition was pH 7.0-8.0. In addition, the (GOx/PBA-PAMAM) 10 film decomposed in glucose solutions owing to the oxidative scission of carbon-boron bond of PBA-PAMAM by enzymatically produced hydrogen peroxide. Thus, the potential use of the (GOx/PBA-PAMAM) 10 film for the development of pH-and glucosesensitive devices is suggested.

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“…Continuing their efforts to develop micellar insulin delivery platforms, Jiang and co‐workers created systems based on random copolymers of 13 and PEG monomethyl ether methacrylate. [ 145 ] These monomers were polymerised in a radical process using 3‐phenylpyruvic acid as a photo‐initiator, at which point insulin could be loaded into the micelles. The authors found that insulin release was temperature dependent, with increased temperature causing increased release.…”

Section: Micelles and Vesiclesmentioning

confidence: 99%

Insulin Delivery Using Dynamic Covalent Boronic Acid/Ester‐Controlled Release

Banach

Williams

Fossey

2021

Advanced Therapeutics

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The number of people affected by diabetes mellitus increases globally year on year. Elevated blood glucose levels may result from a lack of insulin to manage these levels and can, over a prolonged period, lead to serious repercussions. Diabetes mellitus patients must monitor and control their blood‐glucose levels with invasive testing and often alongside administration of intravenous doses of insulin, which can often lead to suboptimal compliance. To mitigate these issues, “closed‐loop” insulin delivery systems are deemed to be among superior options for rapid relief from the demanding and troublesome necessity of self‐directed care. The reversible dynamic covalent chemistry of boronic acid derivatives and their competitive affinity to 1,2‐ and 1,3‐diols (such as those present in saccharides) allows for the design and preparation of responsive self‐regulated insulin delivery materials which respond to elevated and changing glucose levels. A range of meritorious and noteworthy contributions in the domain of boron‐mediated insulin delivery materials is surveyed, and providing a multidisciplinary context in the realisation of the ambitious goal of ultimately addressing the desire to furnish glucose‐responsive insulin delivery materials through innovative synthesis and rigorous testing is targetted.

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Photo-induced synthesis glucose-responsive carriers for controlled release of insulin in vitro

Cited by 17 publications

References 31 publications

Preparation of glucose‐sensitive and fluorescence micelles via a combination of photoinitiated polymerization and chemoenzymatic transesterification for the controlled release of insulin

Preparation of glucose‐sensitive and fluorescence micelles via a combination of photoinitiated polymerization and chemoenzymatic transesterification for the controlled release of insulin

Preparation of multilayer films consisting of glucose oxidase and poly(amidoamine) dendrimer and their stability

Insulin Delivery Using Dynamic Covalent Boronic Acid/Ester‐Controlled Release

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