Photo-induced enhanced Raman spectroscopy for universal ultra-trace detection of explosives, pollutants and biomolecules

Ben‐Jaber, Sultan; Peveler, William J.; Quesada-Cabrera, Raúl; Cortés, Emiliano; Sotelo-Vázquez, Carlos; Abdul-Karim, Nadia; Maier, Stefan A.; Parkin, Ivan P.

doi:10.1038/ncomms12189

Cited by 211 publications

(283 citation statements)

References 45 publications

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“…All the examples described above are referred to spherical resonators, but interesting opportunities for light management at the nanoscale are expected also for other shapes (nanowires, nanodots, nanoribbons, …) . All‐dielectric core/shell systems can also be associated with plasmonic nanoantennas for triggering and monitoring light‐driven surface reactions or stimulating new ways to enhance the Raman response, as reported in the case of photon‐induced enhanced Raman scattering . Their colloidal nature makes core/shell beads particularly suitable for integration in paper‐based sensors that exploit novel detection strategies and in optical‐fiber devices.…”

Section: Discussionmentioning

confidence: 99%

All‐dielectric core/shell resonators: From plasmon‐free SERS to multimodal analysis

Bontempi

Vassalini

Alessandri

2018

J Raman Spectroscopy

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All‐dielectric materials are emerging as a new class of substrates for enhanced Raman scattering. As ohmic losses are reduced in the absence of plasmonic metals, Raman data obtained with dielectrics are very reproducible and reliable. This mini‐review summarizes our recent work in the field of core/shell dielectric resonators designed for Raman purposes, with a special focus on SiO2/TiO2 (T‐rex) core/shell beads. These systems are able to exploit the evanescent field generated by total internal reflection and multiple scattering of light at the sphere‐to‐sphere interface to multiply the number of Raman photons, improving the sensitivity of Raman detection and extending the application of surface enhanced Raman scattering for investigating surface chemical reactions. Examples of the application of T‐Rex beads in detecting and monitoring environmental pollutants, greenhouse gases, biochemical species, and biochemical reactions are presented. The use of core/shell resonators for multimodal analysis based on the combination of surface enhanced Raman scattering with either mass spectrometry or refractive index optical sensing is also discussed, suggesting different possible future developments.

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Section: Discussionmentioning

confidence: 99%

All‐dielectric core/shell resonators: From plasmon‐free SERS to multimodal analysis

Bontempi

Vassalini

Alessandri

2018

J Raman Spectroscopy

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“…gold nanoparticles) (Ben-Jaber et al, 2016;Le Ru and Etchegoin, 2008;Le Ru and Etchegoin, 2012;Li et al, 2010). The enhancement of the signals is mainly caused by two effects: electromagnetic (EM) enhancement and a chemical contribution (Osawa and Ikeda, 1991).…”

Section: Sers Experiments With Ultrasmall Gold Nanoparticlesmentioning

confidence: 99%

Continuous flow synthesis of ultrasmall gold nanoparticles in a microreactor using trisodium citrate and their SERS performance

Huang

Toit

Besenhard

et al. 2018

Chemical Engineering Science

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“…Observation of the interaction of light with matter provides us with a host of tools to promote research, security, safety, and health. These optical tools include the detection of harmful or explosive materials (1)(2)(3), the remote detection of chemicals from a distance (4), the optical diagnosis of colloidal suspensions for genomics and drug delivery (5), and even the use of lasers for defense (6). Remote sensing techniques (7) allow us to image/detect structures through the atmosphere or ocean.…”

mentioning

confidence: 99%

Enhanced coupling of light into a turbid medium through microscopic interface engineering

Thompson

Hokr

Kim

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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There are many optical detection and sensing methods used today that provide powerful ways to diagnose, characterize, and study materials. For example, the measurement of spontaneous Raman scattering allows for remote detection and identification of chemicals. Many other optical techniques provide unique solutions to learn about biological, chemical, and even structural systems. However, when these systems exist in a highly scattering or turbid medium, the optical scattering effects reduce the effectiveness of these methods. In this article, we demonstrate a method to engineer the geometry of the optical interface of a turbid medium, thereby drastically enhancing the coupling efficiency of light into the material. This enhanced optical coupling means that light incident on the material will penetrate deeper into (and through) the medium. It also means that light thus injected into the material will have an enhanced interaction time with particles contained within the material. These results show that, by using the multiple scattering of light in a turbid medium, enhanced light-matter interaction can be achieved; this has a direct impact on spectroscopic methods such as Raman scattering and fluorescence detection in highly scattering regimes. Furthermore, the enhanced penetration depth achieved by this method will directly impact optical techniques that have previously been limited by the inability to deposit sufficient amounts of optical energy below or through highly scattering layers.turbid media | enhanced transmittance | optical coupling | optical scattering | spectroscopy O ptical detection and spectroscopy has drastically changed the way we look at and measure the world today. Observation of the interaction of light with matter provides us with a host of tools to promote research, security, safety, and health. These optical tools include the detection of harmful or explosive materials (1-3), the remote detection of chemicals from a distance (4), the optical diagnosis of colloidal suspensions for genomics and drug delivery (5), and even the use of lasers for defense (6). Remote sensing techniques (7) allow us to image/detect structures through the atmosphere or ocean. Optical methods are also an integral part of biomedical research, diagnosis (8), and treatment (9) of many of today's most prevalent illnesses (10). However, the sensitivity and usefulness of any optical method is severely limited by the occurrence of optical scattering. This limitation is further amplified when the density of scatterers is high enough for multiple scattering to occur. In this article, we show that modification of the geometry of the optical interface significantly improves the coupling efficiency of light into a highly scattering medium, thereby reducing the detrimental effects of scattering. This enhanced coupling is evident through the observation of increased spatial diffusion, two orders of magnitude greater transmission, and over an order of magnitude greater interaction time of light within the material. This translates...

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Photo-induced enhanced Raman spectroscopy for universal ultra-trace detection of explosives, pollutants and biomolecules

Cited by 211 publications

References 45 publications

All‐dielectric core/shell resonators: From plasmon‐free SERS to multimodal analysis

All‐dielectric core/shell resonators: From plasmon‐free SERS to multimodal analysis

Continuous flow synthesis of ultrasmall gold nanoparticles in a microreactor using trisodium citrate and their SERS performance

Enhanced coupling of light into a turbid medium through microscopic interface engineering

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