Continuous flow synthesis of ultrasmall gold nanoparticles in a microreactor using trisodium citrate and their SERS performance

Huang, He; Toit, Hendrik du; Besenhard, Maximilian O.; Ben‐Jaber, Sultan; Dobson, Peter J.; Parkin, Ivan P.; Gavriilidis, Asterios

doi:10.1016/j.ces.2018.06.050

Cited by 70 publications

(53 citation statements)

References 67 publications

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“…By using very short residence times and immediately quenching the outlet stream, the authors were able to access sizes much smaller than those ever obtained in batch via the Turkevich method. Sub-3 nm particles were recently synthesized by Huang et al 30 via citrate reduction of tetrachloroauric acid. Such small size was attributed to an enhancement of the nucleation rate caused by an interaction between the negatively-charged reactor surface and the gold precursor.…”

Section: Introductionmentioning

confidence: 99%

Highly reproducible, high-yield flow synthesis of gold nanoparticles based on a rational reactor design exploiting the reduction of passivated Au(iii)

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Highly reproducible, high-yield flow synthesis of gold nanoparticles based on a rational reactor design exploiting the reduction of passivated Au(iii)

et al. 2020

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“…2 | CHALLENGES FOR MAKING WATER-DISPERSIBLE AND STABLE SUB-5 NM NANOPARTICLES 2.1 | Size uniformed sub-5 nm crystalline At the sub-5 nm extremely small size scale, controlling the size and crystallinity requires more precise chemistry and experimental conditions. In the early years of development and investigation to understand fundamentals in nanomaterials, sub-5 nm nanoparticles were often prepared as the clusters of atoms/molecules using noble metals (Hong et al, 2012;Huang et al, 2018;Jin, Zeng, Zhou, & Chen, 2016;Tang et al, 2014), such as Au, Ag, and Pd, assembled on the solid phase matrices. Among those, Au nanoparticles have been studied the most extensively to understand the mechanisms and approaches for precisely controlling the cluster sizes and inherited size-dependent fluorescent and plasmonic properties, leading the way for developing other types of sub-5 nm nanocomposites for specific biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Going even smaller: Engineering sub‐5 nm nanoparticles for improved delivery, biocompatibility, and functionality

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Huang

et al. 2020

WIREs Nanomed Nanobiotechnol

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The rapid development and advances in nanomaterials and nanotechnology in the past two decades have made profound impact in our approaches to individualized disease diagnosis and treatment. Nanomaterials, mostly in the range of 10-200 nm, developed for biomedical applications provide a wide range of platforms for building and engineering functionalized structures, devices, or systems to fulfill the specific diagnostic and therapeutic needs. Driven by achieving the ultimate goal of clinical translation, sub-5 nm nano-constructs, in particular inorganic nanoparticles such as gold, silver, silica, and iron oxide nanoparticles, have been developed in recent years to improve the biocompatibility, delivery and pharmacokinetics of imaging probes and drug delivery systems, as well as in vivo theranostic applications. The emerging studies have provided new findings that demonstrated the unique size-dependent physical properties, physiological behaviors and biological functions of the nanomaterials in the range of the sub-5 nm scale, including renal clearance, novel imaging contrast, and tissue distribution. This advanced review attempts to introduce the new strategies of rational design for engineering nanoparticles with the core sizes under 5 nm in consideration of the clinical and translational requirements. We will provide readers the update on recent discoveries of chemical, physical, and biological properties of some biocompatible sub-5 nm nanomaterials as well as their demonstrated imaging and theranostic applications, followed by sharing our perspectives on the future development of this class of nanomaterials.

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“…47 Recent advances of micro-reactor technology allow them to be made via facile flow synthesis. 48,49 Au clusters have been shown to have excellent antimicrobial activity. 50,51 Moving up along the length scale (5-100+ nm), there exist a wide variety of Au nanocrystals with different shapes (Fig.…”

Section: Classification Of Hybrid Gold Nanoparticlesmentioning

confidence: 99%

Recent advances in gold nanoparticles for biomedical applications: from hybrid structures to multi-functionality

et al. 2019

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Continuous flow synthesis of ultrasmall gold nanoparticles in a microreactor using trisodium citrate and their SERS performance

Cited by 70 publications

References 67 publications

Highly reproducible, high-yield flow synthesis of gold nanoparticles based on a rational reactor design exploiting the reduction of passivated Au(iii)

Highly reproducible, high-yield flow synthesis of gold nanoparticles based on a rational reactor design exploiting the reduction of passivated Au(iii)

Going even smaller: Engineering sub‐5 nm nanoparticles for improved delivery, biocompatibility, and functionality

Recent advances in gold nanoparticles for biomedical applications: from hybrid structures to multi-functionality

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