Photo-enzyme catalysis enabled E → Z isomerization of alkenes

Efficient stereoselective synthesis of aryl lactones using engineered ketoreductase ChKRED20 from Chryseobacterium sp. CA49

“…Based on our previous work on enzyme-photocatalysis systems, 16 we utilized a cheap and readily achieved photocatalyst called TBADT (tetrabutylammonium decatungstate) to expand the scope of γ-keto esters. Using a simple aldehyde and methyl acrylate as starting materials, we synthesized a series of γ-keto esters (Table S2,† 1a–28a , a represents substrate keto esters and e represents the corresponding lactones).…”

Synthesis Enabled by E-to-Z Isomerization Using CBZ6 as Energy Transfer Photocatalyst

“…Therefore, there are limited strategies for the synthesis of ( Z )-isomers over ( E )-isomers during double bond formation. The most common strategy is the E to Z photoisomerization catalyzed by various photosensitizers. − A typical example is the regioselectivity of the Beckmann rearrangement, in which the substituent opposite to the hydroxyl group migrates to the iminyl cation. Actually, only the E -isomer normally is readily available.…”