Photo-crosslinkable amniotic membrane hydrogel for skin defect healing

Zhang, Qiang; Chang, Caiwang; Qian, Chunyu; Xiao, Wanshu; Zhu, Huajun; Guo, Jun; Meng, Zhibing; Cui, Wenguo; Zhang, Ge

doi:10.1016/j.actbio.2021.02.043

Cited by 80 publications

(63 citation statements)

References 52 publications

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“…The characteristic peak of acry‐lamide at 3315.40 cm −1 was observed, indicating the grafting of GelMA. [ 36 ] Then, the surface composition was detected by X‐ray photoelectron spectroscopy (XPS) (Figure 4c). The high‐resolution spectra for carbon elements showed stronger peak of CO/CN bonds in GelMA decorated PCL/Col patch (Figure 4d,e) with a 2.1 times higher area ratio of CO/CN bonds and CC/CH bonds (Figure 4f), confirming the successful decoration of GelMA coating.…”

Section: Resultsmentioning

confidence: 99%

Programmable Building of Radially Gradient Nanofibrous Patches Enables Deployment, Bursting Bearing Capability, and Stem Cell Recruitment

Yao

Wang

et al. 2021

Adv Funct Materials

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Fibrous patches capable of withstanding bursting force and recruiting endogenous stem cells are of great demand for wound treatment. A programmable strategy for development of radially gradient nanofibrous patches with rapid deployment property, robust bursting bearing capability, and excellent mesenchymal stem cell (MSC) recruitment capability, is demonstrated. Benefiting from the royal water lily‐like radially branched architecture, the gradient fibrous (GF) patches exhibit fast deployment in aqueous solution (2 s), high bursting strength of 4.6 N, as well as “center‐to‐periphery” gradient immobilization of stromal‐cell‐derived factor 1α (SDF1α). The SDF1α gradient patches direct MSC migration from the periphery to the center along the aligned nanofibers, resulting in a 4.2 times higher migrated cell number and 2.6 times greater maximum migration distance than random fibrous patches with homogenous SDF1α. The gelatin methacryloyl coated GF patches respond to matrix metalloproteinase‐9 for “on‐demand” release of anti‐inflammatory drug diclofenac sodium (DS). Furthermore, repair of the mouse full‐thickness skin incision validates that SDF1α/DS/GF patches are able to provide feasible microenvironment to attenuate inflammation and improve endogenous MSC recruitment, leading to accelerated wound healing. This work may open a new pathway for development of smart tough fibrous patches for stimulating endogenous repair mechanisms during tissue regeneration.

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Section: Resultsmentioning

confidence: 99%

Programmable Building of Radially Gradient Nanofibrous Patches Enables Deployment, Bursting Bearing Capability, and Stem Cell Recruitment

Yao

Wang

et al. 2021

Adv Funct Materials

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“…Fibronectin was chosen as a positive control in this study since it is a major component of placental hydrogels beside collagen, laminin and hyaluronic acid [ 62 , 63 ]. It was investigated whether the additional presence of laminin and other structural proteins in the hpcECM-gel might lead to an increased endothelialization than pure fibronectin.…”

Section: Discussionmentioning

confidence: 99%

Chorion-derived extracellular matrix hydrogel and fibronectin surface coatings show similar beneficial effects on endothelialization of expanded polytetrafluorethylene vascular grafts

Rohringer

Schneider

Eder

et al. 2022

Materials Today Bio

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“…Similarly, combination of Amnio-M powder with methacrylated gelatin (GelMA) hydrogel could enhance mucosa regeneration through enhancing vascularization [ 172 ]. The same group used GelMA-Amnio-M composite in skin regeneration, showing adequate collagen deposition, as well as proper mechanical properties [ 173 ]. Integration of the dAmnio-M with nano-fibrous fibroin enhanced the in vitro differentiation of menstrual blood MSCs into keratinocyte [ 174 ].…”

Section: Essential Considerations For Biomedical Applications Of the Amnio-mmentioning

confidence: 99%

Applications of the amniotic membrane in tissue engineering and regeneration: the hundred-year challenge

et al. 2022

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The amniotic membrane (Amnio-M) has various applications in regenerative medicine. It acts as a highly biocompatible natural scaffold and as a source of several types of stem cells and potent growth factors. It also serves as an effective nano-reservoir for drug delivery, thanks to its high entrapment properties. Over the past century, the use of the Amnio-M in the clinic has evolved from a simple sheet for topical applications for skin and corneal repair into more advanced forms, such as micronized dehydrated membrane, amniotic cytokine extract, and solubilized powder injections to regenerate muscles, cartilage, and tendons. This review highlights the development of the Amnio-M over the years and the implication of new and emerging nanotechnology to support expanding its use for tissue engineering and clinical applications. Graphical Abstract

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Photo-crosslinkable amniotic membrane hydrogel for skin defect healing

Cited by 80 publications

References 52 publications

Programmable Building of Radially Gradient Nanofibrous Patches Enables Deployment, Bursting Bearing Capability, and Stem Cell Recruitment

Programmable Building of Radially Gradient Nanofibrous Patches Enables Deployment, Bursting Bearing Capability, and Stem Cell Recruitment

Chorion-derived extracellular matrix hydrogel and fibronectin surface coatings show similar beneficial effects on endothelialization of expanded polytetrafluorethylene vascular grafts

Applications of the amniotic membrane in tissue engineering and regeneration: the hundred-year challenge

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