Photo-cross-linkable hyaluronic acid bioinks for bone and cartilage tissue engineering applications

Ghorbani, Farnaz; Ghalandari, Behafarid; Khajehmohammadi, Mehran; Bakhtiary, Negar; Tolabi, Hamidreza; Sahranavard, Melika; Karkan, Sonia Fathi; Nazar, Vida; Niar, Shalaleh Hasan Niari; Armoon, Amirhosein; Ettelaei, Maryam; Banizi, Milad Tavakoli; Collins, Maurice N.

doi:10.1080/09506608.2023.2167559

Cited by 24 publications

(15 citation statements)

References 272 publications

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“…[ 43 ] Scaffolds for disease modeling and tissue culture for reconstruction are only two of its many emerging uses in bioengineering. [ 44 ] Cellular investigations demonstrate that tailored scaffolds with increased alkaline phosphatase activity and higher production of osteocalcin biomarkers promote positive cell adhesion and vitality. [ 45 ] Scaffold processing biomaterials are presented, and they range from inorganic biomaterials to natural and synthetic polymers and associated composites.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of a design for a three‐dimensional‐printed artificial bone structure

Alarifi

2023

Polymer Composites

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In this work, artificial bones composed of hydroxyapatite (HA)/polyacrylonitrile (PAN) and polylactic acid (PLA) were prepared as a potential replacement for natural bone. The cylindrical specimens included an auxetic system with artificial osteons. HA/PAN and PLA were used to fabricate composite filaments by fused deposition modeling three‐dimensional (3D) printing, and the obtained filaments were applied to produce reentrant artificial bone materials. Scanning electron microscopy was used to analyze the scaffold morphology and functional groups. Energy‐dispersive X‐ray spectroscopy was used for elemental analysis. The compressive properties of the samples were studied to determine the optimal scaffolding prototype. Compressive tests were also performed to assess the behavior of the cellular structure from a mechanical perspective. Finally, ANOVA and residual plots were used to investigate the contributions of the design elements, predict the y‐coordination of the stress values, and evaluate the printing orientation. The results indicated that the auxetic cells influenced the bone macrostructure, which displayed different stiffness characteristics in one working direction. Polymeric solution biomaterials based on HA/PAN and PLA biopolymers have enormous potential as high‐performance liquid synthetic organic polymers for light‐supported extrusion‐based 3D printing. PLA/HA scaffoldings with outstanding medical conversion capability may be used as biomaterial composites for bone deficiency restoration.Highlights Composite filaments for FDM 3D printing were used to manufacture reentrant artificial bone. A replacement method was utilized to determine the porosity of the scaffolds. Mechanically, this cellular structure was evaluated using compressive studies. SEM was used to assess scaffold morphology, functional categories, and elements. Create biodegradable constructions using as little material as possible.

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Section: Resultsmentioning

confidence: 99%

Evaluation of a design for a three‐dimensional‐printed artificial bone structure

Alarifi

2023

Polymer Composites

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“…Future direction of these 3D tissue models are to be used to treat skeletal and connective tissue diseases. 43 The authors believe that these 3D tissue constructs can be further used as individualized cosmetic fillers in difficult areas such as the chin and nose. These findings can further provide personalized HA fillers that can cater to a patient's individual needs and unique facial anatomy.…”

Section: Future Applications Of Hamentioning

confidence: 99%

“…The degree of cross‐linking, strength and overall durability of these 3D tissue constructs can be further modified through controlling the intensity and duration of UV light exposure. Future direction of these 3D tissue models are to be used to treat skeletal and connective tissue diseases 43 . The authors believe that these 3D tissue constructs can be further used as individualized cosmetic fillers in difficult areas such as the chin and nose.…”

Section: Future Applications Of Hamentioning

confidence: 99%

Other hyaluronic acid fillers and combination fillers

Lee,

Hebel,

Snyder

et al. 2023

Dermatological Reviews

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The use of hyaluronic acid (HA) fillers has become increasingly popular in the cosmetic industry due to their efficacy and versatility. Common types of HA fillers include Restylane, Juvéderm, and Bolotero. Other various options available for HA fillers include the resilient HA fillers (RHA) collection, Revanesse versa, and Prevelle silk. The fillers can be used singularly or in combination to achieve a desired cosmetic outcome. The RHA collection line is the first FDA approved filler used to treat dynamic facial lines using a less rigid formula than earlier HA fillers and by uniquely adapting to facial movement, stretching, and repeated facial compression. Revanesse versa filler is designed to effectively address moderate to severe facial wrinkles, including nasolabial folds, with a focus on providing lasting results even after the HA filler has been absorbed. Other HA fillers such as Prevelle silk, Hydrelle, and Puragen contain 0.3% lidocaine for more tolerable treatment for moderate to severe facial lines. Examples of combination fillers include HA/botulinum toxin, HA/calcium hydroxyapatite (CaHA), and HA/poly‐ l‐lactic acid. To facilitate the administration of injections, HA fillers can also be mixed with agents such as lidocaine, lidocaine and epinephrine, normal saline, and sterile water to decrease viscosity. Furthermore, the use of CaHA in conjunction with microfocused ultrasound with visualization (MFU‐V) has shown to enhance skin tightness and neocollagenesis. Other applications of HA include utilization of its bacteriostatic effects to coat biomedical devices, as a material for bioink and tissue‐engineering, and to create novel formulations to further personalize cosmetic goals.

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“…In fact, the raw material used to make the hydrogels has gained a lot of interest nowadays, since they are being used as bioinks in the 3D printing. Although this review is not focused on bioprinting, it is noteworthy to mention that one of the most widely used biomaterials in bioprinting are the photo‐cross‐linkable hyaluronic acid hydrogels 86 . Here, authors highlight in a detailed way how hyaluronic acid hydrogels have been implemented in both in vitro and in vivo studies to treat cartilage pathologies, indicating that hyaluronic acid based bioinks are promising candidates for cartilage tissue engineering.…”

Section: Treatments To Restore Hyaline Cartilagementioning

confidence: 99%

Anatomy, molecular structures, and hyaluronic acid – Gelatin injectable hydrogels as a therapeutic alternative for hyaline cartilage recovery: A review

Vaca‐González,

Culma,

Nova

et al. 2023

J Biomed Mater Res

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Cartilage damage caused by trauma or osteoarthritis is a common joint disease that can increase the social and economic burden in society. Due to its avascular characteristics, the poor migration ability of chondrocytes, and a low number of progenitor cells, the self-healing ability of cartilage defects has been significantly limited. Hydrogels have been developed into one of the most suitable biomaterials for the regeneration of cartilage because of its characteristics such as high-water absorption, biodegradation, porosity, and biocompatibility similar to natural extracellular matrix.Therefore, the present review article presents a conceptual framework that summarizes the anatomical, molecular structure and biochemical properties of hyaline cartilage located in long bones: articular cartilage and growth plate. Moreover, the importance of preparation and application of hyaluronic acidgelatin hydrogels for cartilage tissue engineering are included. Hydrogels possess benefits of stimulating the production of Agc1, Col2α1-IIa, and SOX9, molecules important for the synthesis and composition of the extracellular matrix of cartilage. Accordingly, they are believed to be promising biomaterials of therapeutic alternatives to treat cartilage damage.

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Photo-cross-linkable hyaluronic acid bioinks for bone and cartilage tissue engineering applications

Cited by 24 publications

References 272 publications

Evaluation of a design for a three‐dimensional‐printed artificial bone structure

Evaluation of a design for a three‐dimensional‐printed artificial bone structure

Other hyaluronic acid fillers and combination fillers

Anatomy, molecular structures, and hyaluronic acid – Gelatin injectable hydrogels as a therapeutic alternative for hyaline cartilage recovery: A review

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