Phosphorylcholine-based encoded hydrogel microparticles with enhanced fouling resistance for multiplex immunoassays

“…[78][79][80] Similar to the SAMs and polymer brushes, the PEG and zwitterionic based hydrogels are commonly used for immunoassays. [81][82][83][84][85][86] Yang and co-workers reported a crosslinked cylinder gel array based 3D immunoassay with an antifouling polymer brush as a background (Fig. 5A).…”

Section: Hydrogel Coatingmentioning

confidence: 99%

Surface modification for improving immunoassay sensitivity

Zhou

Zheng

2023

Lab Chip

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“…For label-assisted encoding hydrogel probes, biofouling will also become an important problem, limiting its application in complex environments [ 116 ]. Currently, widely used PEG-encoding hydrogel probes are trapped in coagulation problems in the whole blood environment and cannot provide accurate visualization information [ 117 ].…”

Section: Biomedical Applications Of Zwitterionic Hydrogelsmentioning

confidence: 99%

“…PMPC-encoding hydrogel not only successfully achieved multiple immunoassays but also enhanced the sensitivity of probes because of the improvement of antifouling performance. In platelet-rich plasma, PMPC-encoding hydrogel increased the antifouling effect by 70%, which made PMPC-encoding hydrogel promising to be applied in complex clinical conditions [ 116 ].…”

Section: Biomedical Applications Of Zwitterionic Hydrogelsmentioning

confidence: 99%

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Liu

Tang

et al. 2022

Gels

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Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

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“…Likewise, other hormone‐based biomarkers, such as the placental growth factor (PLGF) and chorionic gonadotropin beta (CG beta) as indicators of complications in pregnancy, have also been detected by immunosensors based on hydrogels. [ 327 ]…”

Section: Applications Of Composite Hydrogel‐based Biosensorsmentioning

confidence: 99%

Hydrogel‐based composites: Unlimited platforms for biosensors and diagnostics

Wang

Liu

Wang

et al. 2021

VIEW

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The need for biosensing systems, which are capable of reliable and accurate detection of physiological signals and disease biomarkers along with biocompatible surface chemistry and textures for device–human interface, has driven the continuous search for advanced sensing materials, sensing strategies, and device structures. Hydrogels are hydrophilic polymers with high water content and thus akin to human tissues. They are not only able to act as polymeric matrices to load functional materials for bio‐signal transducing, but also stimuli‐responsive to cooperate with the filler materials for further enhanced sensing performance. A vast combination of hydrogels and functional fillers such as biomacromolecules, metal nanostructures, carbon nanomaterials, and two‐dimensional materials beyond graphene has been demonstrated over the last decade for fabrication of biosensors for disease diagnosis and health monitoring. This review article aims to provide an overview of the various hydrogel‐based composites, introduce their preparation protocols, and describe the working principles of their corresponding sensors. Recent development of these sensors for potential diagnosis of diseases such as diabetes, cancers, and cardiovascular diseases is then summarized, followed by stating the current challenges and prospects in this field.

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Phosphorylcholine-based encoded hydrogel microparticles with enhanced fouling resistance for multiplex immunoassays

Abstract: Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-based hydrogel microparticles were synthesized for multiplex immunoassays with enhanced fouling resistance properties.

Cited by 7 publications

References 57 publications

Surface modification for improving immunoassay sensitivity

Surface modification for improving immunoassay sensitivity

Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Hydrogel‐based composites: Unlimited platforms for biosensors and diagnostics

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