ESD might be a complementary option for the treatment of UD-EGCs, especially in those with SRC-type histology based on strict expanded indications. Nonetheless, close endoscopic surveillance is required because of a high incidence of intragastric recurrence.
Post-synthesis functionalized hydrogel microparticles were demonstrated in multiplex immunoassays with high sensitivity, a wide assay range, and fast detection.
Discontinuous
dewetting (DD) is an attractive technique that enables the production
of large liquid arrays in microwells and is applicable to the synthesis
of anisotropic microparticles with complex morphologies. However,
such loading of liquids into microwells presents a significant challenge,
as the liquids used in this technique should exhibit low mold surface
wettability. This study introduces DD in a degassed mold (DM), a simple
yet powerful technique that achieves uniform loading of microparticle
precursors into large microwell arrays within 1 min. Using this technique,
hydrogel microparticles are produced by different polymerization mechanisms
with various shapes and sizes, ranging from a few micrometers to hundreds
of micrometers. Hydrophobic oil microparticles are produced by the
simple plasma treatment of the DM, and agarose microparticles encapsulating
bovine serum albumin (in a well-dispersed state) are produced by submerging
the DM in fluorinated oil. To demonstrate additional functionality
of microparticles using this technique, high concentrations of magnetic
nanoparticles are loaded into microparticles for particle-based immunoassays
performed in a microwell plate, and the immunoassay performance is
comparable to that of ELISA.
Stimuli-responsive carriers releasing multiple drugs have been researched for synergistic combinatorial cancer treatment with reduced side-effects. However, previously used drug carriers have limitations in encapsulating multiple drug components in a single carrier and releasing each drug independently. In this work, pH-sensitive, multimodulated, anisotropic drug carrier particles are synthesized using an acid-cleavable polymer and stop-flow lithography. The particles exhibit a faster drug release rate at the acidic pH of tumors than at physiological pH, demonstrating their potential for tumor-selective drug release. The drug release rate of the particles can be adjusted by controlling the monomer composition. To accomplish multimodulated drug release, multicompartmental particles are synthesized. The drug release profile of each compartment is programmed by tailoring the monomer composition. These pH-sensitive, multicompartmental particles are promising drug carriers enabling tumor-selective and multimodulated release of multiple drugs for synergistic combination cancer therapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.