Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase Cϵ Regulates Ras/Mitogen-activated Protein Kinase Signaling and Neuronal Differentiation

Lonic, Ana; Powell, Jason A.; Kong, Yang; Thomas, Daniel; Holien, Jessica K.; Truong, Nhan; Parker, Michael W.; Guthridge, Mark A.

doi:10.1074/jbc.m112.421669

Cited by 13 publications

(11 citation statements)

References 50 publications

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“…The activation of FGFR2 has been shown to regulate cell differentiation via PKC. 41,42 Interestingly, the activation of PKC has been shown to be involved in the regulation of blastocoel formation during mouse preimplantation development, 28,43 which is in accordance with our observation that the inhibition of PKC significantly suppressed the formation of expanded blastocysts. More importantly, p38 regulates cavitation and the function of tight junctions, which affects the expanded formation of the blastocyst.…”

supporting

confidence: 80%

Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway

Yang

Zhang

et al. 2015

Cell Cycle

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(2015) Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway, Cell Cycle, 14:20, 3318-3330, DOI: 10.1080/15384101.2015 Keywords: blastocyst formation, fibroblast growth factor 2 (FGF2), fibroblast growth factor receptor 2 (FGFR2), protein kinase C (PKC), p38 MAPK Fibroblast growth factors (FGF1, FGF2 and FGF4) and fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3 and FGFR4) have been reported to be expressed in preimplantation embryos and be required for their development. However, the functions of these molecules in trophectoderm cells (TEs) that lead to the formation of the blastocyst as well as the underlying mechanism have not been elucidated. The present study has demonstrated for the first time that endogenous FGF2 secreted by TEs can regulate protein expression and distribution in TEs via the FGFR2-mediated activation of PKC and p38, which are important for the development of expanded blastocysts. This finding provides the first explanation for the long-observed phenomenon that only high concentrations of exogenous FGFs have effects on embryonic development, but in vivo the amount of endogenous FGFs are trace. Besides, the present results suggest that FGF2/FGFR2 may act in an autocrine fashion and activate the downstream PKC/p38 pathway in TEs during expanded blastocyst formation.

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supporting

confidence: 80%

Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway

Yang

Zhang

et al. 2015

Cell Cycle

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“…Members of the FGFR family play a key role in the regulation of cell proliferation, differentiation, and in the regulation of embryonic development. Previous studies have reported the relationship between FGFR2 gene and the regulation of ERK gene (Schuller et al, 2008;Lonic et al, 2013). Evidence from animal studies demonstrated that ERK gene may have a regulatory function to swallowing reflex in rats (Tsujimura et al, 2009).…”

Section: Discussionmentioning

confidence: 97%

Genetic determinants of swallowing impairments among community dwelling older population

Raginis-Zborowska

Mekli

Payton

et al. 2015

Experimental Gerontology

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“…morphological maturation phenotype). Indeed, upon knocking-down of FGFR2, we may not only affect its interaction with NEGR1, but also with other molecules involved in its downstream signalling ( Williams et al , 1994 ; Lonic et al , 2013 ).…”

Section: Discussionmentioning

confidence: 99%

NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice

Szczurkowska

Pischedda

Pinto

et al. 2018

Brain

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See Contreras and Hippenmeyer (doi:) for a scientific commentary on this article.Autism spectrum disorders (ASDs) are complex conditions with diverse aetiologies. Szczurkowska et al. demonstrate that two ASD-related molecules – FGFR2 and Negr1 – physically interact to act on the same downstream pathway, and regulate cortical development and ASD-relevant behaviours in mice. Identifying common mechanisms in ASDs may reveal targets for pharmacological intervention.

show abstract

Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase Cϵ Regulates Ras/Mitogen-activated Protein Kinase Signaling and Neuronal Differentiation

Cited by 13 publications

References 50 publications

Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway

Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway

Genetic determinants of swallowing impairments among community dwelling older population

NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice

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