Phosphorylation of 10-bromoanthracen-9-yl-cyclopenta[d]isoxazol-6-ols: chemistry suitable for antivirals

Abstract

Regioisomeric nor-nucleoside analogues, brominated at the anthracene ring, have been prepared and phosphorylated according to different protocols affording a variety of phosphate and phosphonate derivatives. Chiral phosphorus derivatives were also obtained as inseparable mixtures of diastereisomers. The synthetic methods are described and found to be reliable and robust, affording nor-nucleosides and nornucleotides, available in large amounts for in vitro antiviral evaluation.

Synthesis and Antimicrobial Activity of some Ester Functionalized Isoxazoles incorporating Anthracene Moieties via Nucleophilic Substitution Reaction

“…15,16 In light of the interesting chemistry of isoxazoles, anthracene and their derivatives and their wide applications in pharmaceutical and biological fields. 17 This investigation delves into an efficient and sustainable synthetic protocol to synthesize and characterize distinct ester-functionalized isoxazoles 6a-j containing anthracene moiety and it is thought to be an advancement to biologically active isoxazoles.…”