Novel benzimidazolium salts and their silver(I)-<i>N</i>-heterocyclic carbene complexes: synthesis, characterization and their biological properties

Belhi, Zeyneb; Karcı, Hüseyin; Dündar, Muhammet; Gürbüz, Nevin; Özdemır, İlknur; Koç, Ahmet; Cheriti, Abdelkrim; Özdemır, İsmaıl

doi:10.1080/00958972.2022.2164191

Cited by 6 publications

(1 citation statement)

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“…The Ag-NHC had shown enhanced bactericidal effects due to the synergistic effects of NaCl which increase solubility product for anionic AgCl 2 − . Recently Belhi et al synthesized four novel morpholinethyl Ag(I)-NHC complexes (259-262) [90]. The MIC of the 1,3-dialkyl-5,6-dimethyl-benzimidazolium salts and their complexes was determined for E. coli, P. aeruginosa, S. aureus, C. glabrata and C. albicans in vitro through BMD (Broth Microdilution).…”

Section: Nhc-silver Complex With Ligand In Dual Activitymentioning

confidence: 99%

Structure–Activity Relationships in NHC–Silver Complexes as Antimicrobial Agents

2023

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Silver has a long history of antimicrobial activity and received an increasing interest in last decades owing to the rise in antimicrobial resistance. The major drawback is the limited duration of its antimicrobial activity. The broad-spectrum silver containing antimicrobial agents are well represented by N-heterocyclic carbenes (NHCs) silver complexes. Due to their stability, this class of complexes can release the active Ag+ cations in prolonged time. Moreover, the properties of NHC can be tuned introducing alkyl moieties on N-heterocycle to provide a range of versatile structures with different stability and lipophilicity. This review presents designed Ag complexes and their biological activity against Gram-positive, Gram-negative bacteria and fungal strains. In particular, the structure–activity relationships underlining the major requirements to increase the capability to induce microorganism death are highlighted here. Moreover, some examples of encapsulation of silver–NHC complexes in polymer-based supramolecular aggregates are reported. The targeted delivery of silver complexes to the infected sites will be the most promising goal for the future.

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Section: Nhc-silver Complex With Ligand In Dual Activitymentioning

confidence: 99%

Structure–Activity Relationships in NHC–Silver Complexes as Antimicrobial Agents

2023

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The first evaluation of the in vitro effects of silver(I)-N-heterocyclic carbene complexes on Encephalitozoon intestinalis and Leishmania major promastigotes

Ataş,

Akın-Polat,

Gülpınar

et al. 2024

J Biol Inorg Chem

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Encephalitozoon intestinalis is an opportunistic microsporidian parasite that primarily infects immunocompromised individuals, such as those with HIV/AIDS or undergoing organ transplantation. Leishmaniasis is responsible for parasitic infections, particularly in developing countries. The disease has not been effectively controlled due to the lack of an effective vaccine and affordable treatment options. Current treatment options for E. intestinalis infection and leishmaniasis are limited and often associated with adverse side effects. There is no previous study in the literature on the antimicrosporidial activities of Ag(I)-N-heterocyclic carbene compounds. In this study, the in vitro antimicrosporidial activities of previously synthesized Ag(I)-N-heterocyclic carbene complexes were evaluated using E. intestinalis spores cultured in human renal epithelial cell lines (HEK-293). Inhibition of microsporidian replication was determined by spore counting. In addition, the effects of the compounds on Leishmania major promastigotes were assessed by measuring metabolic activity or cell viability using a tetrazolium reaction. Statistical analysis was performed to determine significant differences between treated and control groups. Our results showed that the growth of E. intestinalis and L. major promastigotes was inhibited by the tested compounds in a concentration-dependent manner. A significant decrease in parasite viability was observed at the highest concentrations. These results suggest that the compounds have potential anti-microsporidial and anti-leishmanial activity. Further research is required to elucidate the underlying mechanisms of action and to evaluate the efficacy of the compounds in animal models or clinical trials. Graphical abstract

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NHCs silver complexes as potential antimicrobial agents

Isbel,

Patil,

Bugarin

2024

Inorganica Chimica Acta

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Novel benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes: synthesis, characterization and their biological properties

Cited by 6 publications

References 50 publications

Structure–Activity Relationships in NHC–Silver Complexes as Antimicrobial Agents

Structure–Activity Relationships in NHC–Silver Complexes as Antimicrobial Agents

The first evaluation of the in vitro effects of silver(I)-N-heterocyclic carbene complexes on Encephalitozoon intestinalis and Leishmania major promastigotes

NHCs silver complexes as potential antimicrobial agents

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