Phosphorylation Events During Müllerian Duct Regression

Hutson, John M.; Fallat, Mary E.; Kamagata, Shoichiro; Donahoe, Patricia K.; Budzik, Gerald P.

doi:10.1126/science.6607531

Cited by 56 publications

(17 citation statements)

References 44 publications

(25 reference statements)

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“…In addition, portions of the MIS gene and protein were recently found also to be homologous to a hepatocyte-generated monomeric phosphoprotein that inhibits both tyrosine phosphorylation of the insulin receptor and hepatocyte growth (27). MIS has been shown to inhibit autophosphorylation of tyrosine on the EGF receptor (28)(29)(30) and is itself an inhibitor, not only of Mullerian duct growth, but also of selected tumor growth (31)(32)(33). More recently, other potential functions for MIS have been discovered, including oocyte meiosis inhibition (11,12), inhibition of lung surfactant accumulation (34,35), control of testicular descent (36), and inhibition of fetal ovarian differentiation and aromatase activity (37).…”

Section: Discussionmentioning

confidence: 99%

“…The chronological coincidence after birth of changes in serum FSH levels and MIS production in Sertoli cells, as well as the appearance of spermatogonia, together with the discovery that MIS can act as an oocyte meiosis inhibitor (11,12), suggests that MIS may play a role in the regulation of early spermatogenesis. Inhibition of germ cells in both gonads needs to be studied in the context of the known role of MIS in inhibiting tyrosine phosphorylation (28)(29)(30). Featherstone (46) reviewed the concept that a phosphorylation cascade in the cell cycle and cell division might be facilitated by p34, the yeast cdc2 gene product, which is also a component of the maturation promoting factor (MPF) in Xenopus oocytes.…”

Section: Discussionmentioning

confidence: 99%

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Mullerian Inhibiting Substance Ontogeny and its Modulation by Follicle-Stimulating Hormone in the Rat Testes*

et al. 1990

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Mullerian Inhibiting Substance (MIS) production in rat testes from the late fetal to the adult period and its modulation by gonadotropins in neonatal testes were studied using immunohistochemistry, northern analysis, and a graded organ culture bioassay for MIS. The intense immunohistochemical staining for MIS seen in fetal and newborn testes began to decrease gradually after the third postnatal day, then decreased dramatically on the fifth postnatal day. MIS immunohistochemical activity was then present at a low level until about the 20th postnatal day, after which it was barely detectable. The testes from rats treated with FSH at birth showed a considerable drop in MIS immunohistochemical activity on the third postnatal day to 29% of control testes, and a less profound decrease on the second and fourth postnatal days to 46% and 61% of control, respectively; thereafter MIS levels were the same in treated and untreated animals. With shorter courses of FSH treatment, immunohistochemical staining showed less depression of MIS on the third day, and no difference by the fourth postnatal day, indicating that the inhibitory effect on testicular MIS production may require continued FSH exposure. Three-day testes that had been treated with FSH for 2-1/2 days had less MIS messenger RNA compared to control testes of the same age, suggesting that the inhibitory effect of FSH on MIS production could be transcriptionally mediated. In contrast LH treatment produced no difference in either messenger RNA expression or immunohistochemical staining for MIS. These findings suggested that FSH may be a modulator of MIS production in neonatal testes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mullerian Inhibiting Substance Ontogeny and its Modulation by Follicle-Stimulating Hormone in the Rat Testes*

et al. 1990

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“…The structure has not yet been characterized and information regarding its mechanism of action is limited. It has been shown that mullerian duct regression, in vitro, requires a 24-36-h exposure to MIF, and that MIF acts extracellularly by causing dephosphorylation of a membrane protein (31); its intracellular effect appears to be inhibited by cyclic AMP (cAMP) (32).…”

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confidence: 99%

The unique endocrine milieu of the fetus.

Fisher¹

1986

J. Clin. Invest.

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“…4). These observations could be related to the known antagonistic effects of EGF on Miillerian inhibiting factor activity in both the reproductive ducts [46] and the ovary [47]. EGF, or its embryonic analog TGFac, could have a regulatory role in proliferation and differentiation of the Wolffian duct and regression of the Muillerian duct in fetal males.…”

Section: Discussionmentioning

confidence: 88%

Ontogeny of the Epidermal Growth Factor Receptor during Development of the Fetal Bovine Mesonephros and Associated Organs of the Urogenital Tract1

Winters

Febres

Fulgham

et al. 1993

Biology of Reproduction

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A primary cell culture system was developed to study the epidermal growth factor (EGF) receptor in the fetal bovine mesonephros and its urogenital derivatives. Radioreceptor assays demonstrated EGF binding as early as Day 37 in mesonephric cells and in cells derived from the fetal reproductive ducts, gonads, and metanephros--all mesonephric derivatives. Immunocytochemical studies revealed that EGF receptors were localized in the ductal and tubular epithelium of these urogenital organs. EGF induced DNA synthesis and tyrosine phosphorylation in the bovine mesonephric cells, suggesting that EGF receptors detected in these cells were functional. In addition, transforming growth factor alpha, the putative fetal ligand for the EGF receptor, was found to specifically compete for EGF binding to the receptor, as well as to induce DNA synthesis in a manner similar to that of EGF. Estrogen did not regulate EGF receptors or specifically bind to bovine mesonephric cells. The development of estrogen receptors in the bovine species occurs markedly later than that of the EGF receptor, in contrast to the mouse, where both receptors are observed at very early stages of reproductive tract development.

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Phosphorylation Events During Müllerian Duct Regression

Cited by 56 publications

References 44 publications

Mullerian Inhibiting Substance Ontogeny and its Modulation by Follicle-Stimulating Hormone in the Rat Testes*

Mullerian Inhibiting Substance Ontogeny and its Modulation by Follicle-Stimulating Hormone in the Rat Testes*

The unique endocrine milieu of the fetus.

Ontogeny of the Epidermal Growth Factor Receptor during Development of the Fetal Bovine Mesonephros and Associated Organs of the Urogenital Tract1

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