The unique endocrine milieu of the fetus.

Fisher, Delbert A.

doi:10.1172/jci112616

Cited by 65 publications

(24 citation statements)

References 108 publications

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“…In addition to hCRH, hCG, and chorionic somatomammotropin, several other peptide hormones are expressed in the human placenta (27). These include ACTH (28), thyrotropinreleasing hormone (29), gonadotropin-releasing hormone (30), and somatostatin (31).…”

Section: Discussionmentioning

confidence: 99%

Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta.

Frim¹,

Emanuel²,

Robinson³

et al. 1988

J. Clin. Invest.

266

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Corticotropin-releasing hormone (CRH), a hypothalamic neuropeptide involved in the regulation of ACTH secretion, has been detected by RIA in extracts of human placenta. We wished to determine whether this immunoreactive substance is a product of CRH gene expression in the placenta. We have found authentic human CRH (hCRH) mRNA in human placental tissue that is similar in size to hypothalamic CRH mRNA. Furthermore, the transcriptional initiation site for placental hCRH mRNA is identical to that previously predicted for hypothalamic hCRH mRNA, 23-26 nucleotides downstream from a canonical promoter element. Placental hCRH mRNA increases more than 20-fold in the 5 wk preceding parturition, in parallel with a rise in placental hCRH peptide content. These data strongly suggest that the hCRH gene is expressed in the placenta and that this expression changes dramatically during gestation.

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Section: Discussionmentioning

confidence: 99%

Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta.

Frim¹,

Emanuel²,

Robinson³

et al. 1988

J. Clin. Invest.

266

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“…In the mammalian foetus, plasma calcium levels are maintained at a higher level than maternal by means of a placental calcium pump which is driven by some hitherto unknown mechanism (Fisher, 1986). Plasma PTH levels by radioimmunoassay are lower in the foetus than in the mother, but PTH-like bioactivity, measured by a sensitive cytochemical assay, is higher in the foetus than in the mother (Allgrove et a/., 198 I, 1985).…”

Section: Genomic Structure O F Pthrpmentioning

confidence: 99%

Parathyroid Hormone‐related Protein in Hypercalcaemia of Malignancy

Martın

Suva

1989

Clinical Endocrinology

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“…To cite an example of the roles of gonadotropins in fetal physiology, sexual differentiation is associated with hCG [10] and FSH [11]. Because the fetal liver develops morphologically and functionally, the ontogenesis of ASGP receptor is of interest.…”

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confidence: 99%