Phosphorus Effects of Mesoporous Bioactive Glass on Occlude Exposed Dentin

Abstract

In recent studies, sealing of exposed dentinal tubules is generally considered as one of the most effective strategies to treat dentin hypersensitivity. Mesoporous bioactive glass (MBG) is a potential material for treating dentin hypersensitivity due to its highly specific areas for dissolution and re-precipitated reaction for reduction in dentin permeability. The groups of commercial products of PerioGlas®, synthetic MBG and MBG without phosphorus (MBGNP) were compared. The MBG and MBGNP powders were prepared by the sol-gel method and mixed with different calculated ratios of phosphoric acid (PA) and then was brushed onto dentin surfaces. We used X-ray diffractometer (XRD), scanning electronic microscope (SEM), and Fourier transform infrared spectroscopy (FTIR) to investigate the physiochemistry and the occlusion ability of dentinal tubules. The results showed that MBG paste mixed with PA solution has a better ability for occluding dentinal tubules than MBGNP; it has a short reaction time and good operability. The major crystallite phase of MBG agents was monocalcium phosphate monohydrate [Ca(H2PO4)2·H2O] in the early stages of the reactions. MBG pastes that were mixed with 30% and 40% PA had the ability to create excellent penetration depth greater than 80 μm. These agents have the potential to treat dentin hypersensitivity.

Nano/micro fluorhydroxyapatite crystal pastes in the treatment of dentin hypersensitivity: an in vitro study

“…4(A-C)). The occlusion achieved by FA/poly(DMAco-MEA) paste was higher than that reported by Chen et al [32] in 2013 which was 68 % using Mesoporous Bioactive Glass (MBG) mixed with phosphoric acid.…”

Mesoporous Bioactive Glass Combined with Graphene Oxide Quantum Dot as a New Material for a New Treatment Option for Dentin Hypersensitivity

“…BAG as one of DH treatment modelities has been studied for a long time. Ion dissolution, osteoconductivity and apatite forming ability of BAG promotes remineralization on the dentin surface through mechanically occluding dentinal tubules [2,11,13,14,17]. In some previous observations, incomplete closure of the dentinal tubule was observed.…”

“…BAG releases calcium, sodium, and phosphate ions to raise the pH and create the precipitation of calcium phosphate and mineralization into hydroxyapatite [6][7][8][9][10]. Because of their buffering and apatite-forming abilities, BAG can be considered as great alternative for dentin hypersensitivity treatment [2,[11][12][13][14][15]. However, BAG, which covered dentinal tubule, appeared to be removed easily by chemical and physical stimuli [16].…”

Avaliação ex vivoda obliteração de túbulos dentinários humanos pelo uso comparativo de agentes dessensibilizantes convencionais e dessensibilizantes contendo biovidro

“…Para o desenvolvimento do estudo foram utilizados 12 pré-molares inferiores humanos hígidos, extraídos por indicação clínica, adquiridos no Banco de Dentes da Faculdade de Odontologia da UFJF, baseado nos relatos de autores (MANTZOURANI e SHARMA, 2013; SHARIF, IRAM e BRUNTON, 2013) que afirmaram serem esses os dentes mais comumente afetados por hipersensibilidade dentinária (AYAD et al, 2009;CHEN et al, 2013 A desinfecção destes foi realizada no Laboratório de Pesquisa da Faculdade de Odontologia da Universidade Federal de Juiz de Fora, com 20.000 partes por milhão (ppm) de hipoclorito de sódio durante 24h sob temperatura ambiente. Em seguida, realizou-se um corte vestíbulo-lingual 2 mm acima da região cervical dos dentes e com altura e largura de 4 mm e um outro corte sagital para que ficasse com 4 mm de espessura, ambos com o auxílio de uma cortadeira metalográfica (Iomet® 1000, Buehler, Estados Unidos da América).…”

“…Vários métodos e materiais têm tentado reduzir a HD, dentre eles, destacam-se os dentifrícios dessensibilizantes, por serem facilmente e amplamente disponíveis, terem baixo custo e simples aplicação, além de não serem invasivos (ACHARYA, SURVE e THAKUR, 2013;DE OLIVEIRA et al, 2013;DOCIMO et al, 2009;SCHIFF et al, 2009). Os tratamentos para HD podem atuar de duas formas, dessensibilizando quimicamente os nervos sensoriais e bloqueando a transmissão de estímulos nocivos dos túbulos dentinários para o sistema nervoso central, ou ocluindo os túbulos dentinários abertos, a fim de bloquear o mecanismo hidrodinâmico (CHEN et al, 2013;CUMMINS, 2009;DE OLIVEIRA et al, 2013;DOCIMO et al, 2011;MARKOWITZ, 2013;OLLEY et al, 2012;PALAZON et al, 2013;PATEL et al, 2011;SCHIFF et al, 2009;SHARIF, IRAM e BRUNTON, 2013). A oclusão dos túbulos dentinários ocorre pela precipitação de fosfato de cálcio na superfície dentinária, sendo o cálcio um componente frequentemente presente nos dentifrícios (COSTA et al, 2016).…”