2017
DOI: 10.1016/j.cca.2017.09.005
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Phosphorus and mortality risk in end-stage renal disease: A meta-analysis

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Cited by 36 publications
(21 citation statements)
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“…Moreover, severe acute hypophosphatemia may cause cardiac and respiratory failure, leading to death [ 9 ]. On the other hand, high extracellular P i is similarly associated with adverse health outcomes, including coronary artery calcification, worsening renal function, premature aging, and increased mortality [ 10 , 11 , 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, severe acute hypophosphatemia may cause cardiac and respiratory failure, leading to death [ 9 ]. On the other hand, high extracellular P i is similarly associated with adverse health outcomes, including coronary artery calcification, worsening renal function, premature aging, and increased mortality [ 10 , 11 , 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…More recently, Hou et al’s meta-analysis of nine cohort studies (including a total of 1,992,869 patients with ESRD requiring dialysis) revealed that both abnormally high and abnormally low serum phosphate levels were independently associated with an increased risk of all-cause mortality in this population (hazard ratio (HR) [95% confidence interval (CI)] = 1.39 [1.31–1.47] and 1.16 [1.06–1.28], respectively). Moreover, serum phosphate levels were non-linearly associated with all-cause mortality in dialysis-dependent patients with ESRD [ 27 ].…”
Section: Phosphatementioning
confidence: 99%
“…The interplay among protein intake, sP, and serum albumin (sAlb) levels raises a clinical conundrum when managing patients' sP. Hyperphosphatemia and hypoalbuminemia are independent risk factors for mortality among dialysis patients, thus clinicians may be wary of correcting one risk factor at the "expense" of the other [2][3][4][5]. Reducing dietary protein consumption, while limiting phosphate intake, can result in reduced sAlb, decreased normalized protein catabolic rate (nPCR), and protein-energy wasting (PEW).…”
Section: Introductionmentioning
confidence: 99%