Phosphorus-31 MR Spectroscopy in Pediatric Liver Transplant Recipients: A Noninvasive Assessment of Graft Status with Correlation with Liver Function Tests and Liver Biopsy

Lam, William W. Y.; Lee, Kim-Hung; Yeung, D.; Sihoe, Jennifer Dart Yin; Yeung, Chung‐Kwong

doi:10.2214/ajr.184.5.01841624

Cited by 12 publications

(3 citation statements)

References 16 publications

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“…1.5 [47] Effects of intravenous ATP infusion for 22-24 hours on liver energy status in advanced lung cancer patients.…”

Section: [43]mentioning

confidence: 99%

Non-invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

Jones¹

2021

Preprint

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The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform the status of both hepatic and systemic metabolic diseases as well as the disposition of medications. As a tool to better understand liver metabolism in these settings, in vivo magnetic resonance spectroscopy (MRS) offers a non-invasive means of monitoring hepatic metabolic activity in real time both by direct observation of concentrations and dynamics of specific metabolites as well as by observation of their enrichment by stable isotope tracers. This review summarizes the applications and advances in human liver metabolic studies by in vivo MRS over the past 35 years and discusses future directions and opportunities that will be opened by the development of ultra-high field MR systems and by hyperpolarized stable isotope tracers.

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“…1.5 [47] Effects of intravenous ATP infusion for 22-24 hours on liver energy status in advanced lung cancer patients.…”

Section: [43]mentioning

confidence: 99%

Non-invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

Jones¹

2021

Preprint

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“…Studies utilizing this method have shown promise in differentiating the etiology of diffuse parenchymal disease [56][57][58] as well as liver regeneration subsequent to resection 59 and transplant complications not related to vascular or biliary etiology. 60 …”

Section: Mr Spectroscopymentioning

confidence: 99%

Hepatic Imaging in the 21st Century

2006

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Imaging of the liver has progressed rapidly during the past decade with continued advancement of current ultrasound, computed tomography, and magnetic resonance imaging (MRI). Each modality not only has seen refinement enabling better anatomic characterization of disease but also has received strength from the addition of new techniques to its resources. New contrast agents have become available for all modalities and some agents, particularly for MRI, have opened the way for better functional assessment. MRI continues to see an elaboration of sequences (including spectroscopy and diffusion) that also open imaging to the microscopic structure of disease and normal function. The further development of workstations have improved both analysis and depiction of disease. In the 21st century imaging will continue to shift from a simple source of anatomic information to a more functional problem-solving tool.

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“…Both 31 P MRS and 1 H-MRS have been applied to estimate liver lipid content. In vivo hepatic 31 P MRS provides non-invasive information about phospholipid metabolism, intrahepatocellular lipids and also hepatic functional status [90][91][92]. A typical 31 P MRS spectrum of the human liver in vivo contains resonances which can be assigned to phosphomonoesters, phosphodiesters, inorganic phosphate, and nucleotide triphosphates, including ATP [90].…”

Section: Magnetic Resonance Spectroscopy Study Of Nonadipose Tissues mentioning

confidence: 99%

Imaging of Visceral Adipose Tissue: An Emerging Diagnostic Tool and Therapeutic Target

Iacobellis¹

2005

CDTCHD

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Several lines of evidence support the contention that excess visceral fat plays a significant role in the development of an unfavourable metabolic and cardiovascular risk profile. Hence, estimation of visceral adipose tissue (VAT), that is, the fat surrounding the internal organs, might be important for cardiovascular risk stratification. Classically, anthropometric measures have been employed to assess body fat distribution for risk assessment. But more recently, imaging methods for visceral fat quantitation have become a focus of attention particularly in a clinical research setting. Several imaging methods have evolved for estimation of VAT mass. Among these, magnetic resonance imaging (MRI) is fairly well established, but ultrasound and magnetic resonance spectroscopy (MRS) are also emerging as useful methods for quantitation of VAT and fat tissue content in vivo. Ultrasound is the most cost-effective and a convenient imaging tool whereas MRS is still in its infancy but it is highly promising because of its high sensitivity and specificity. There is a compelling need to quantify VAT not only for diagnostic purposes, but also for therapeutic interventions with weight reduction drugs or pharmaceuticals targeted to with adipose tissue. For example, changes in regional fat distribution can be used to estimate drugs effectiveness and their mechanism of action. Therefore, in this review I shall present briefly latest and main imaging techniques to detect the visceral adiposity, including the new ultrasound measurements of different visceral adipose tissue compartments. Some visceral adipose tissues which are not traditionally assessed, such as intraperitoneal, mediastinal and the relatively small depots, such as epicardial adipose tissue have also been recently studied and are now proposed as new markers of visceral adiposity.

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Phosphorus-31 MR Spectroscopy in Pediatric Liver Transplant Recipients: A Noninvasive Assessment of Graft Status with Correlation with Liver Function Tests and Liver Biopsy

Cited by 12 publications

References 16 publications

Non-invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

Non-invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

Hepatic Imaging in the 21st Century

Imaging of Visceral Adipose Tissue: An Emerging Diagnostic Tool and Therapeutic Target

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