Phosphopyridoxal complexes with histamine and histidine (5) the kinetics of cyclic compound formation between histamine and pyridoxal-5′-phosphate in the presence of pig kidney diamine oxidase and rat intestinal histaminase

Sasiak, K.; Kierska, D.; Maśliński, Cz.

doi:10.1007/bf01964876

Cited by 3 publications

(1 citation statement)

References 19 publications

(16 reference statements)

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“…One relevant pathway might be the transsulfuration pathway for which the by-product of cysteine degradation H 2 S is a smooth muscle relaxant 58,59 , while another one might be the degradation pathway of the pro-contractile sphingosine-1-phosphate 60,61 . We cannot also exclude the possibility that PLP might have another beneficial effect through formation of an inactive cyclic compound with histamine 62,63 . However, we note that this appears to be a relatively rare event in the micromolar range (involving only 7% of PLP at equimolar concentrations of 10 µM) 44 and most likely the reason why it was not detected in our experimental conditions using histamine at 50 µM and PLP at 10-200 µM (Fig.…”

Section: Discussionmentioning

confidence: 99%

Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles

Nerée

Soret

Marcocci

et al. 2020

Sci Rep

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Excess of histamine in gut lumen generates a pronounced gastrointestinal discomfort, which may include diarrhea and peristalsis dysfunctions. Deleterious effects of histamine can be alleviated with antihistamine drugs targeting histamine receptors. However, many antihistamine agents come with various undesirable side effects. Vegetal diamine oxidase (vDAO) might be a relevant alternative owing to its histaminase activity. Mammalian intestinal mucosa contains an endogenous DAO, yet possessing lower activity compared to that of vDAO preparation. Moreover, in several pathological conditions such as inflammatory bowel disease and irritable bowel syndrome, this endogenous DAO enzyme can be lost or inactivated. Here, we tested the therapeutic potential of vDAO by focusing on the well-known effect of histamine on gut motility. Using ex vivo and in vitro assays, we found that vDAO is more potent than commercial anti-histamine drugs at inhibiting histamine-induced contraction of murine distal colon muscles. We also identified pyridoxal 5′-phosphate (the biologically active form of vitamin B6) as an effective enhancer of vDAO antispasmodic activity. Furthermore, we discovered that rectally administered vDAO can be retained on gut mucosa and remain active. These observations make administration of vDAO in the gut lumen a valid alternative treatment for histamine-induced intestinal dysfunctions.

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Section: Discussionmentioning

confidence: 99%

Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles

Nerée

Soret

Marcocci

et al. 2020

Sci Rep

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In vivo formation of histamine phosphopyridoxal cyclic compounds

1981

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A possibility of in vivo formation of cyclic compounds between histamine (Hi) given i.p. and endogenous pyridoxal (PL) or pyridoxal 5'-phosphate (PLP) has been studied. Cyclic compounds of Hi with PL or PLP were found in all tissues examined. Although an increase in Hi levels in tissues enhances the formation of cyclic compounds, no simple relationship between the rate of formation and Hi concentration has been observed. The reaction seems to be limited by endogenous PLP. The cyclic products Hi-PL and Hi-PLP were discovered in urine. It is suggested that the process of cyclic compound formation may reduce PLP resources, resulting in a modification of PLP-enzyme activities.

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Phosphopyridoxal cyclic compounds with histamine and histidine. 6: The formation of phosphopyridoxal cyclic compounds with histamine and histidine in the presence of biological material

1978

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We have studied the dynamics of cyclic compound formation between histamine or histidine and pyridoxal 5'-phosphate (Hi-PLP or His-PLP) in incubates of rat gastric mucosa histidine decarboxylase (HD), rat intestinal diamine oxidase (DAO) or homogenates of either rat liver, intestine or gastric mucosa. For gastric mucosa HD, liver and gastric mucosa homogenates, the rate of cyclization was slightly decreased; however, the rate was significantly inhibited with intestinal DAO or intestinal homogenate. Binding of PLP by tissue components was measured; free PLP was bound abundantly by rat intestinal DAO and by rat intestinal homogenate. A possible mechanism by which intestinal tissues inhibit cyclic compound formation is discussed.

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Phosphopyridoxal complexes with histamine and histidine (5) the kinetics of cyclic compound formation between histamine and pyridoxal-5′-phosphate in the presence of pig kidney diamine oxidase and rat intestinal histaminase

Cited by 3 publications

References 19 publications

Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles

Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles

In vivo formation of histamine phosphopyridoxal cyclic compounds

Phosphopyridoxal cyclic compounds with histamine and histidine. 6: The formation of phosphopyridoxal cyclic compounds with histamine and histidine in the presence of biological material

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