Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles

Nerée, Armelle Tchoumi; Soret, Rodolphe; Marcocci, Lucia; Pietrangeli, Paola; Pilon, Nicolas; Mateescu, Mircea Alexandru

doi:10.1038/s41598-020-78134-3

Cited by 8 publications

(5 citation statements)

References 71 publications

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“…The DAOs isolated from vegetal and animal sources have already been investigated for the histamine reduction in foods and the intestine (Naila et al 2015 ; Kettner et al 2020 ; Neree et al 2020 ). The microbial HOX have not yet been comprehensively investigated for these applications.…”

Section: Application Of Histamine-oxidizing Enzymes For the Histamine...mentioning

confidence: 99%

Recent advances in the application of microbial diamine oxidases and other histamine-oxidizing enzymes

Kettner

Seitl

Fischer

2022

World J Microbiol Biotechnol

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The consumption of foods fraught with histamine can lead to various allergy-like symptoms if the histamine is not sufficiently degraded in the human body. The degradation occurs primarily in the small intestine, naturally catalyzed by the human diamine oxidase (DAO). An inherent or acquired deficiency in human DAO function causes the accumulation of histamine and subsequent intrusion of histamine into the bloodstream. The histamine exerts its effects acting on different histamine receptors all over the body but also directly in the intestinal lumen. The inability to degrade sufficient amounts of dietary histamine is known as the ‘histamine intolerance’. It would be preferable to solve this problem initially by the production of histamine-free or -reduced foods and by the oral supplementation of exogenous DAO supporting the human DAO in the small intestine. For the latter, DAOs from mammalian, herbal and microbial sources may be applicable. Microbial DAOs seem to be the most promising choice due to their possibility of an efficient biotechnological production in suitable microbial hosts. However, their biochemical properties, such as activity and stability under process conditions and substrate selectivity, play important roles for their successful application. This review deals with the advances and challenges of DAOs and other histamine-oxidizing enzymes for their potential application as processing aids for the production of histamine-reduced foods or as orally administered adjuvants to humans who have been eating food fraught with histamine.

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Section: Application Of Histamine-oxidizing Enzymes For the Histamine...mentioning

confidence: 99%

Recent advances in the application of microbial diamine oxidases and other histamine-oxidizing enzymes

Kettner

Seitl

Fischer

2022

World J Microbiol Biotechnol

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“…Additionally, vegetal DAO from pea has already been investigated for a possible treatment of histamine-related symptoms under simulated intestinal conditions [34][35][36]. Thereby, the half-life period of pea DAO in an SIF was at around 18 h and thereby higher than the microbial DAO-1 [36].…”

Section: Histamine Bioconversion Using Dao-1 Tabletsmentioning

confidence: 99%

Toward Oral Supplementation of Diamine Oxidase for the Treatment of Histamine Intolerance

2022

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A new diamine oxidase (DAO-1) was discovered recently in the yeast Yarrowia lipolytica PO1f and investigated for its histamine degradation capability under simulated intestinal conditions. DAO-1 was formulated together with catalase as a sucrose-based tablet. The latter (9 × 7 mm; 400 mg) contained 690 nkat of DAO-1 activity, which was obtained from a bioreactor cultivation of a genetically modified Y. lipolytica with optimized downstream processing. The DAO-1 tablet was tested in a histamine bioconversion experiment under simulated intestinal conditions in the presence of food constituents, whereby about 30% of the histamine was degraded in 90 min. This amount might already be sufficient to help people with histamine intolerance. Furthermore, it was found that the stability of DAO-1 in a simulated intestinal fluid is influenced distinctively by the presence of a food matrix, indicating that the amount and type of food consumed affect the oral supplementation with DAO. This study showed for the first time that a microbial DAO could have the potential for the treatment of histamine intolerance by oral supplementation.

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“…Some findings suggested that serum DAO values agree with symptoms of HIT [ 31 ]. In vitro and in vivo observations in mice, including administration of DAO into the gut lumen, were found to be a valid treatment for histamine-induced intestinal dysfunctions [ 32 ]. DAO made from the white pea ( Lathyrus sativus ) prevented histamine toxicity in vitro in human epithelial colorectal adenocarcinoma cells [ 33 ].…”

Section: Histamine Intolerance (Hit)mentioning

confidence: 99%

Histamine Intolerance Originates in the Gut

Schnedl¹,

Enko

2021

Nutrients

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Histamine intolerance (HIT) is assumed to be due to a deficiency of the gastrointestinal (GI) enzyme diamine oxidase (DAO) and, therefore, the food component histamine not being degraded and/or absorbed properly within the GI tract. Involvement of the GI mucosa in various disorders and diseases, several with unknown origin, and the effects of some medications seem to reduce gastrointestinal DAO activity. HIT causes variable, functional, nonspecific, non-allergic GI and extra-intestinal complaints. Usually, evaluation for HIT is not included in differential diagnoses of patients with unexplained, functional GI complaints or in the here-listed disorders and diseases. The clinical diagnosis of HIT is challenging, and the thorough anamnesis of all HIT-linked complaints, using a standardized questionnaire, is the mainstay of HIT diagnosis. So far, DAO values in serum have not been established to correlate with DAO activity in the gut, but the diagnosis of HIT may be supported with determination of a low serum DAO value. A targeted dietary intervention, consisting of a histamine-reduced diet and/or supplementation with oral DAO capsules, is helpful to reduce HIT-related symptoms. This manuscript will present why histamine should also be taken into account in the differential diagnoses of patients with various diseases and disorders of unknown origin, but with association to functional gastrointestinal complaints. In this review, we discuss currently increasing evidence that HIT is primarily a gastrointestinal disorder and that it originates in the gut.

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Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles

Cited by 8 publications

References 71 publications

Recent advances in the application of microbial diamine oxidases and other histamine-oxidizing enzymes

Recent advances in the application of microbial diamine oxidases and other histamine-oxidizing enzymes

Toward Oral Supplementation of Diamine Oxidase for the Treatment of Histamine Intolerance

Histamine Intolerance Originates in the Gut

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