Phosphoproteomics reveals the BRAF-ERK1/2 axis as an important pathogenic signaling node in cartilage degeneration

Dong, Yonghui; Wang, Ping; Zhang, Meng; Xiao, Lixin; Yang, Yong‐Guang; Wang, Baoya; Liu, Yunke; Dai, Zhipeng; Zheng, Jia

doi:10.1016/j.joca.2022.08.003

Cited by 3 publications

(1 citation statement)

References 56 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More specific proteomic approaches also provide functional insights into OA pathophysiology. For example, a specific screen for phosphorylated proteins (phosphoproteomics) has suggested an important role of the B-Raf/ERK pathway in cartilage degeneration in OA [14]. Finally, Apte et al [15 ▪ ] presented a degradomic study of human OA cartilage to determine proteins subject to degradation, which appears particularly relevant given the large number of proteases acting in OA, for many of which we do not know the physiological substrates.…”

Section: Proteomicsmentioning

confidence: 99%

The impact of omics research on our understanding of osteoarthritis and future treatments

Beier¹

2022

Current Opinion in Rheumatology

View full text Add to dashboard Cite

Purpose of reviewTo review recent studies using Omics approaches (genomics, proteomics, metabolomics, single cell analyses) in patient populations and animal models of osteoarthritis (OA), with the goal of identifying disease-modifying mechanisms that could serve as therapeutic and diagnostic targets. Recent findingsThe number of genes, pathways and molecules with potential roles in OA pathogenesis has grown substantially over the last 18 months. Studies have expanded from their traditional focus on cartilage and gene expression to other joint tissues, proteins and metabolites. Single cell approaches provide unprecedented resolution and exciting insights into the heterogeneity of cellular activities in OA. Functional validation and investigation of underlying mechanisms in animal models of OA, in particular genetically engineered mice, link Omics findings to pathophysiology and potential therapeutic applications.

show abstract

Section: Proteomicsmentioning

confidence: 99%

The impact of omics research on our understanding of osteoarthritis and future treatments

Beier¹

2022

Current Opinion in Rheumatology

View full text Add to dashboard Cite

show abstract

Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies

Rai,

Collins,

Lang

et al. 2024

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

The Genetics and Functional Genomics of Osteoarthritis

Arruda,

Katsoula,

Chen

et al. 2024

Annual Review of Genomics and Human Genetics

View full text Add to dashboard Cite

Osteoarthritis is the most prevalent whole-joint degenerative disorder, and is characterized by the degradation of articular cartilage and the underlying bone structures. Almost 600 million people are affected by osteoarthritis worldwide. No curative treatments are available, and management strategies focus mostly on pain relief. Here, we provide a comprehensive overview of the available human genetic and functional genomics studies for osteoarthritis to date and delineate how these studies have helped shed light on disease etiopathology. We highlight genetic discoveries from genome-wide association studies and provide a detailed overview of molecular-level investigations in osteoarthritis tissues, including methylation-, transcriptomics-, and proteomics-level analyses. We review how functional genomics data from different molecular levels have helped to prioritize effector genes that can be used as drug targets or drug-repurposing opportunities. Finally, we discuss future directions with the potential to drive a step change in osteoarthritis research.

show abstract

Phosphoproteomics reveals the BRAF-ERK1/2 axis as an important pathogenic signaling node in cartilage degeneration

Cited by 3 publications

References 56 publications

The impact of omics research on our understanding of osteoarthritis and future treatments

The impact of omics research on our understanding of osteoarthritis and future treatments

Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies

The Genetics and Functional Genomics of Osteoarthritis

Contact Info

Product

Resources

About