Phosphonic Acid Monolayers for Binding of Bioactive Molecules to Titanium Surfaces

Adden, Nina; Gamble, Lara J.; Castner, David G.; Hoffmann, Andrea; Groß, Gerhard; Menzel, Henning

doi:10.1021/la060754c

Cited by 241 publications

(272 citation statements)

References 38 publications

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“…Several studies have showed the presence of such hydrocarbon contaminant species on different metal oxides. [31][32][33][34] Also, the C u C peak of hydrocarbon contamination at 285 eV has been commonly used as an internal standard for XPS calibration. 34 The C 1s spectrum of SAM-Cou Cr alloy was deconvoluted into three components as well.…”

Section: Xps Characterizationmentioning

confidence: 99%

Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Mani

Torres

2011

Biointerphases

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Polymer-based platforms in drug-eluting stents ͑DESs͒ can cause adverse reactions in patients. Hence, the development of a polymer-free drug delivery platform may reduce adverse reactions to DES. In this study, the use of a polymer-free platform, self-assembled monolayers ͑SAMs͒, is explored for delivering an antiproliferative drug ͓paclitaxel ͑PAT͔͒ from a stent material ͓cobalt-chromium ͑͑Cou Cr͒ alloy͔. Initially, carboxylic acid terminated phosphonic acid SAMs were coated on Cou Cr alloy. Two different doses ͑25 and 100 g / cm 2 ͒ of PAT were coated on SAM coated Cou Cr surfaces using a microdrop deposition method. Also, control experiments were carried out to coat PAT directly on Cou Cr surfaces with no SAM modification. The PAT coated specimens were characterized using the Fourier transform infrared spectroscopy ͑FTIR͒, scanning electron microscopy ͑SEM͒, and atomic force microscopy ͑AFM͒. FTIR spectra showed the successful deposition of PAT on SAM coated and control-Cou Cr surfaces. SEM images showed islands of high density PAT crystals on SAM coated surfaces, while low density PAT crystals were observed on control-Cou Cr alloy. AFM images showed molecular distribution of PAT on SAM coated as well as control-Cou Cr alloy surfaces. In vitro drug release studies showed that PAT was released from SAM coated Cou Cr surfaces in a biphasic manner ͑an initial burst release in first 7 days was followed by a slow release for up to 35 days͒, while the PAT was burst released from control-Cou Cr surfaces within 1-3 days. Thus, this study demonstrated the use of SAMs for delivering PAT from Cou Cr alloy surfaces for potential use in drug-eluting stents.

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Section: Xps Characterizationmentioning

confidence: 99%

Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Mani

Torres

2011

Biointerphases

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“…The phosphonate in gelatin was considered to be concentrated at the interface with titanium. Similarly, Adden et al 32 and Viornery et al 33 also investigated the interactions of phosphonic acid linked to organic compounds with titanium by ToF-SIMS, and found strong indications of the formation of a chemical link, such as a Ti-O-P bond, between titanium and phosphonic acid molecules. According to Hotchkiss et al 50 monolayers formed by phosphonic acids on metal oxide are more resistant to hydrolysis than those formed by silanes or carboxylic acids.…”

Section: Abbreviationmentioning

confidence: 97%

“…[23][24][25] Such phosphate groups have been found in the underwater adhesive proteins of the sandcastle worm and caddy silks, 16,17 which interact specifically with a titanium surface. [26][27][28][29][30][31][32][33] In previous studies, we have anchored various extracellular matrices and growth factors onto metal to provide a source of signals to continuously, stably, and efficiently stimulate cells to reconstitute damaged tissues during long-term regeneration. [34][35][36] Therefore, it may be useful to prepare metal-anchored proteins using biomimetic methods for convenient surface modification.…”

mentioning

confidence: 99%

Nanolayer formation on titanium by phosphonated gelatin for cell adhesion and growth enhancement

Zhou¹,

Park²,

Mao³

et al. 2015

IJN

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Phosphonated gelatin was prepared for surface modification of titanium to stimulate cell functions. The modified gelatin was synthesized by coupling with 3-aminopropylphosphonic acid using water-soluble carbodiimide and characterized by 31 P nuclear magnetic resonance and gel permeation chromatography. Circular dichroism revealed no differences in the conformations of unmodified and phosphonated gelatin. However, the gelation temperature was changed by the modification. Even a high concentration of modified gelatin did not form a gel at room temperature. Time-of-flight secondary ion mass spectrometry showed direct bonding between the phosphonated gelatin and the titanium surface after binding. The binding behavior of phosphonated gelatin on the titanium surface was quantitatively analyzed by a quartz crystal microbalance. Ellipsometry showed the formation of a several nanometer layer of gelatin on the surface. Contact angle measurement indicated that the modified titanium surface was hydrophobic. Enhancement of the attachment and spreading of MC-3T3L1 osteoblastic cells was observed on the phosphonated gelatin-modified titanium. These effects on cell adhesion also led to growth enhancement. Phosphonation of gelatin was effective for preparation of a cell-stimulating titanium surface.

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“…Another approach is to chemically modify titanium prostheses or other materials, if necessary including reactive groups that are able to bind growth factors and to release them slowly. We and others could show that such an approach is able to induce biological activity in model cell lines and in vivo as well, see, e. g. [7,8]. Despite many successful efforts to solve the problem of long-term delivery by strategies like the one just discussed many researchers may prefer gene-therapeutic strategies (cf.…”

Section: Towards Future Innovative Strategies: Animal Modelsmentioning

confidence: 99%

Innovative Strategies for Treatment of Soft Tissue Injuries in Human and Animal Athletes

Hoffmann¹,

Groß²

2009

Genetics and Sports

Self Cite

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Abstract.Our aim is to review here some recent progress in the management of musculo-skeletal disorders.We will cover novel therapeutic approaches based on growth factors, gene therapy and cells including stem cells which may be combined with each other as appropriate. We focus mainly on the treatment of soft tissue injuries -muscle, cartilage, and tendon/ligament for both human and animal athletes. The need for innovative strategies results from the fact that despite all efforts, the current strategies for cartilage and tendon/ligament still result in the formation of functionally and biomechanically inferior tissues after injury (a phenomenon called "repair" as opposed to proper "regeneration") whereas the outcome for muscle is more favourable. Innovative approaches are urgently needed not only to enhance the outcome of conservative or surgical procedures but also to speed up the healing process from the very long disabling periods which is of special relevance for athletes.Introduction.

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Phosphonic Acid Monolayers for Binding of Bioactive Molecules to Titanium Surfaces

Cited by 241 publications

References 38 publications

Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Nanolayer formation on titanium by phosphonated gelatin for cell adhesion and growth enhancement

Innovative Strategies for Treatment of Soft Tissue Injuries in Human and Animal Athletes

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