Phospholipids in Synaptic Function

Hawthorne, J. N.; Pickard, M. R.

doi:10.1111/j.1471-4159.1979.tb04503.x

Cited by 233 publications

(88 citation statements)

References 89 publications

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“…These membranemediated processes might be candidates for the PEC interactions. Although there are reports dealing with nerve cells in which high-frequency electric currents have affected phospholipids turnover [24] and translocation of PKC [25], our results suggest that in the neutrophil OF3 response, the PEC effect is tightly connected with Ca'+ mobilization. Ca?'…”

Section: Discussioncontrasting

confidence: 58%

Pulsed electric current enhances the phorbol ester induced oxidative burst in human neutrophils

et al. 1992

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Oxidative burst (OB) response in human ncutrophils. measured with chcmiluminesccncc (CL), has been used to dcterminc whether pulsed electric current (PEC) might induce a functional response in these electrically nonexcitable cells, and also whether it might modify cellular response to tumor-promoting pborbol ester (PMA). Five minutes of PEC lreatmcnt caused no significant chanBcs in ncutrophil CL levels in HBSS (I.2 mM Ca" concentration) aa well as in HBSS-EGTA, where the extracellular Ca2+ concentration was reduced to less than 30 nM. The CL level of PMA-activated neutrophils in HBSS was 52% higher than in HBSS-EGTA. In HBSS the CL Icvcl, after the combined PMA and PEC treatment, was 53% higher than in PMA-alone-treated ncutrophils. Activation of the OB in HBSS-EGTA with PMA and PEC was 15% higher than in solely PMA treated neutrophils. The results suggest that in ncutrophil OB response, the PEC effect is closely rclatcd with cellular calcium mobilization, since deplction of extracellular Ca"' decreased tbc PEC effect.

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Section: Discussioncontrasting

confidence: 58%

Pulsed electric current enhances the phorbol ester induced oxidative burst in human neutrophils

et al. 1992

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“…Nevertheless, the decreased enzyme activities of Table 2 may be pertinent to diabetic neuropathy since phosphatidylinositol and its derivatives are implicated in nerve conduction. Transmission at certain synapses involves hydrolysis and resynthesis of phosphatidylinositol (Michell, 1975), and phosphatidylinositol 4,5-bisphosphate may be involved both in axonal conduction (Hawthorne & Kai, 1970) and in synaptic responses to Ca2+ ions (Hawthorne & Pickard, 1979). The impaired synthesis now reported in diabetic nervous tissue may lead to the decrease in conduction velocity that is well established (Eliasson, 1964;Hildebrand et al, 1968;Greene et al, 1975).…”

Section: Mg2+ Nad+mentioning

confidence: 99%

Enzymes of myo-inositol and inositol lipid metabolism in rats with streptozotocin-induced diabetes

Whiting¹,

Palmano²,

Hawthorne³

1979

Biochemical Journal

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Diabetes, with only mild ketosis, was induced in male rats by a single injection of streptozotocin. After 12 weeks the specific activities of enzymes concerned with the metabolism of inositol and of inositol lipids were measured in various tissues. Inositol 1-phosphate synthase (EC 5.5.1.4) was most active in testis and the activity was significantly less in diabetic rats than in controls on a similar diet. Inositol oxygenase (EC 1.13.99.1), which converts myo-inositol into glucuronic acid, was also less active in kidney from diabetic animals. CDP-diacylglycerol-inositol phosphatidyltransferase (EC 2.7.8.11) and phosphatidylinositol 4-phosphate kinase (EC 2.7.1.68) showed decreased specific activities in brain and sciatic nerve of diabetic rats. By contrast the diabetic state did not affect the specific activities of phosphatidylinositol kinase (EC 2.7.1.67) or phosphatidylinositol 4,5-bisphosphate phosphatase (EC 3.1.3.36) in these tissues. The results are discussed in relation to diabetic neuropathy.

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“…It has been known for some time that stimulation of nervous tissue increases the turnover of membrane-bound inosine phosphoglyceride in an energy-dependent cycle (Michell, 1975;Hawthorne and Pickard, 1979). However, it will serve our pre s ent discussion better if we consider another stimulus-induced membrane perturb ation, one that has been ad mirably worked out in Axelrod's labo ratory (see Hirata and Axelrod, 1980).…”

Section: Membrane Phos Pholip Ids and Cell Activitymentioning

confidence: 99%