Phospholipid dry powders produced by spray drying processing: structural, thermodynamic and physical properties

Alves, Giuliana Piovesan; Santana, Maria Helena Andrade

doi:10.1016/j.powtec.2004.06.008

Cited by 69 publications

(46 citation statements)

References 8 publications

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“…The characteristic peak of the DPPC at approximately 21 2θ degrees increased with the addition of DPPC in the co-SD MOXI:DPPC formulations. The diagrams revealed the characteristic peak of the DPPC bilayer multilamellar structure in the solid-state 50 at approximately 21 (2θ) degrees.…”

Section: X-ray Powder Diffractionmentioning

confidence: 98%

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Design, characterization, and aerosolization of organic solution advanced spray-dried moxifloxacin and ofloxacin dipalmitoylphosphatidylcholine (DPPC) microparticulate/nanoparticulate powders for pulmonary inhalation aerosol delivery

Duan¹,

Vogt²,

Li³

et al. 2013

IJN

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Section: X-ray Powder Diffractionmentioning

confidence: 98%

“…For co-SD OFLX:DPPC 25:75, there are no sharp diffraction peaks observed, indicating non crystallinity. The diagrams revealed the characteristic peak of the DPPC bilayer multilamellar structure in the solid-state 50 at approximately 21 2θ degrees, which increased in intensity with the addition of DPPC in the SD formulations.…”

Section: X-ray Powder Diffractionmentioning

confidence: 99%

Design, characterization, and aerosolization of organic solution advanced spray-dried moxifloxacin and ofloxacin dipalmitoylphosphatidylcholine (DPPC) microparticulate/nanoparticulate powders for pulmonary inhalation aerosol delivery

Duan¹,

Vogt²,

Li³

et al. 2013

IJN

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“…Notwithstanding, this strategy implies the use of aerosol drugs, whose production is indeed feasible through the spray-drying technology. As reported in the literature, spray drying has revealed to be a powerful tool in fabricating an inhalable powder suitable for lung delivery, since it allows the production of dried, stable and well-defined solid particles within the "respirable size range for pulmonary delivery" [25,26,41,42].…”

Section: Pulmonary Drug Deliverymentioning

confidence: 99%

Spray Drying: An Overview

Santos¹,

Maurício²,

Sencadas³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

115

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Spray drying is a well-known method of particle production which comprises the transformation of a fluid material into dried particles, taking advantage of a gaseous hot drying medium, with clear advantages for the fabrication of medical devices. In fact, it is quite common the production of microspheres and microcapsules designed for drug delivery systems. This review describes the different stages of the mechanism of the spray-drying process: atomization, droplet-to-particle conversion and particle collection. In particular, this work addresses the diversity of available atomizers, the drying kinetics and the importance of the configuration of the drying chamber, and the efficiency of the collection devices. The final properties of the dried products are influenced by a variety of factors, namely the spray dryer design, the feed characteristics and the processing parameters. The impact of those variables in optimizing both the spray-drying process and the synthesis of dried particles with desirable characteristics is discussed. The scalability of this manufacturing process in obtaining dried particles in submicron-to-micron scale favors a variety of applications within the food, chemical, polymeric, pharmaceutical, biotechnology and medical industries.

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“…2,8,14,36 Spray-drying has been used in the microencapsulation of bioactive molecules, as well as in the preparation of drug-delivery systems composed of a large variety of biodegradable polymers and excipients. [37][38][39] It has also been used as a scalable method in the bulk preparation of drug-lipid mixtures. 37,40,41 The unique features and tunable parameters of spray-drying allow for the precise tuning of the particle properties as a result of rational design and engineering.…”

mentioning

confidence: 99%

“…[37][38][39] It has also been used as a scalable method in the bulk preparation of drug-lipid mixtures. 37,40,41 The unique features and tunable parameters of spray-drying allow for the precise tuning of the particle properties as a result of rational design and engineering. The use of an organic solvent allows for much lower moisture content and smaller particle size (down to 400 nm).…”

mentioning

confidence: 99%

Design, physicochemical characterization, and optimization of organic solution advanced spray-dried inhalable dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine poly(ethylene glycol) (DPPE-PEG) microparticles and nanoparticles for targeted respiratory nanomedicine delivery as dry powder inhalation aerosols

Meenach¹,

Vogt²,

Anderson³

et al. 2013

IJN

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Novel advanced spray-dried and co-spray-dried inhalable lung surfactant-mimic phospholipid and poly(ethylene glycol) (PEG)ylated lipopolymers as microparticulate/ nanoparticulate dry powders of biodegradable biocompatible lipopolymers were rationally formulated via an organic solution advanced spray-drying process in closed mode using various phospholipid formulations and rationally chosen spray-drying pump rates. Ratios of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine PEG (DPPE-PEG) with varying PEG lengths were mixed in a dilute methanol solution. Scanning electron microscopy images showed the smooth, spherical particle morphology of the inhalable particles. The size of the particles was statistically analyzed using the scanning electron micrographs and SigmaScan ® software and were determined to be 600 nm to 1.2 µm in diameter, which is optimal for deep-lung alveolar penetration. Differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD) were performed to analyze solid-state transitions and long-range molecular order, respectively, and allowed for the confirmation of the presence of phospholipid bilayers in the solid state of the particles. The residual water content of the particles was very low, as quantified analytically via Karl Fischer titration. The composition of the particles was confirmed using attenuated total-reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy and confocal Raman microscopy (CRM), and chemical imaging confirmed the chemical homogeneity of the particles. The dry powder aerosol dispersion properties were evaluated using the Next Generation Impactor™ (NGI™) coupled with the HandiHaler ® dry powder inhaler device, where the mass median aerodynamic diameter from 2.6 to 4.3 µm with excellent aerosol dispersion performance, as exemplified by high values of emitted dose, fine particle fraction, and respirable fraction. Overall, it was determined that the pump rates defined in the spray-drying process had a significant effect on the solid-state particle properties and that a higher pump rate produced the most optimal system. Advanced dry powder inhalers of inhalable lipopolymers for targeted dry powder inhalation delivery were successfully achieved. Dovepresssubmit your manuscript | www.dovepress.com

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Phospholipid dry powders produced by spray drying processing: structural, thermodynamic and physical properties

Cited by 69 publications

References 8 publications

Design, characterization, and aerosolization of organic solution advanced spray-dried moxifloxacin and ofloxacin dipalmitoylphosphatidylcholine (DPPC) microparticulate/nanoparticulate powders for pulmonary inhalation aerosol delivery

Design, characterization, and aerosolization of organic solution advanced spray-dried moxifloxacin and ofloxacin dipalmitoylphosphatidylcholine (DPPC) microparticulate/nanoparticulate powders for pulmonary inhalation aerosol delivery

Spray Drying: An Overview

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