Phospholipase A2 activating protein is required for 1α,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3

Doroudi, Maryam; Schwartz, Zvi; Boyan, Barbara D.

doi:10.1016/j.jsbmb.2012.03.001

Cited by 35 publications

(37 citation statements)

References 37 publications

(57 reference statements)

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“…Our current study provides the first evidence from immunohistochemistry that shockwave therapy can induce articular cartilages expression of Pdia-3, the critical transcription factor responsible for the matrix formation of chondrocyte. Recent studies reported that 1α,25(OH)2D3 rapidly stimulated membrane signaling via Pdia-3 dependent activation in growth zone chondrocytes and promotes the production of matrix protein [11,13,20,22,42,43]. The present study showed the decrease of cartilage matrix loss and increased aggrecan and collagen II expression in shockwave group.…”

Section: Discussionsupporting

confidence: 62%

“…Extracellular signal-regulated kinases (ERKs), acted as an integration point for multiple biochemical signals, and were involved in an osteoblast cellular processes such as proliferation, differentiation, transcription regulation and development [12,22]. Upon activation by Pdia-3 after ESWT, these kinases translocations to the nucleus of the osteoblast cells, where it phosphorylated nuclear targets.…”

Section: The Expression Of Pdia-3 and Extracellular Signal-regulated mentioning

confidence: 99%

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ESWT Enhances Expression of Pdia-3 which is a Key Factor of 1α,25-Dihydroxyvitamin D3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis Knee

Hsu

Cheng

Wang

et al. 2016

Preprint

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Dysregulation of cartilage homeostasis and the changes in the density and the architecture of the subchondral bone were postulated as a potent mechanically pathological activity contributing to osteoarthritis (OA) pathogenesis. Extracorporeal shockwave therapy (ESWT) is a new, none invasive and effective method in the treatment of animal OA model. In the current study, we demonstrated that shockwave induced the expression of protein-disulfide isomerase-associated 3 (Pdia-3) which is a multifunctional protein hypothesized to be a significant mediator for 1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3) signaling pathway using two-dimensional electrophoresis. Histological analysis and quantitative polymerase chain reaction (qPCR) were verified and observed that the expression of Pdia-3 at 2 weeks was significantly higher than that of any other group at 4 weeks, 8 weeks, and 12 weeks post-shockwave treatment in early OA knee of rat. The other factors of the 1α,25(OH)2D3 rapid membrane signaling pathway including extracellular signal-regulated protein kinases 1 (ERK1), osteopontin (OPG), alkaline phosphatase (ALP), and matrix metallopeptidase 13 (MMP13) were measured and significantly increased by qPCR at 2 weeks post-shockwave treatment in early OA knee. Our proteomic data revealed significant Pdia-3 expression in microenvironments of joint tissue that could be actively responded to ESWT, which may potentially regulate biological function of chondrocytes and osteoblasts in the treatment of OA knee.

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Section: Discussionsupporting

confidence: 62%

Section: The Expression Of Pdia-3 and Extracellular Signal-regulated mentioning

confidence: 99%

ESWT Enhances Expression of Pdia-3 which is a Key Factor of 1α,25-Dihydroxyvitamin D3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis Knee

Hsu

Cheng

Wang

et al. 2016

Preprint

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“…In vitro and in vivo studies have confirmed the expression of PLAA mRNA in the region of the growth plate that is sensitive to 1a,25(OH) 2 D 3 [35]. 1a,25 (OH) 2 D 3 treatment triggers the interaction between PLAA and Pdia3 receptor complex in osteoblasts and chondrocytes [16]. Moreover, silenced PLAA (ShPlaa) osteoblasts fail to rapidly activate PKC and PLA 2 in response to 1a,25(OH) 2 D 3 treatment [16].…”

Section: Wnt5a Signals Via the Camkii/pla 2 /Pge 2 /Pkc Cascadementioning

confidence: 81%

“…1a,25(OH) 2 D 3 initiates its effects via Pdia3 localized in caveolae plasma membrane domains [6,9]. The binding of 1a,25(OH) 2 D 3 to Pdia3 stimulates the interaction between Pdia3 and phospholipase-A 2 (PLA 2 )-activating protein (PLAA) [16], triggering the activation of calcium/calmodulindependent protein kinase II (CaMKII) [17]. Next, PLA 2 is activated [18], generating lysophospholipid and releasing arachidonic acid (AA) [19].…”

mentioning

confidence: 99%

A review of 1α,25(OH)2D3 dependent Pdia3 receptor complex components in Wnt5a non-canonical pathway signaling

Doroudi¹,

Olivares-Navarrete²,

Boyan³

et al. 2015

The Journal of Steroid Biochemistry and Molecular Biology

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“…Arachidonic acid can activate PKC directly through a PLAA mediated pathway or be further metabolized, resulting in PGE 2 production, which then acts through its EP1 receptor leading to MAPK activation. Alternatively, IP 3 stimulates Ca +2 release from the endoplasmic reticulum and activation of PKCα via translocation to the plasma membrane by DAG [38,74] (Fig. 1).…”

Section: Rapid Non-genomic Membrane Signalingmentioning

confidence: 99%

Rapid steroid hormone actions via membrane receptors

Schwartz

Verma

Bivens

et al. 2016

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Steroid hormones regulate a wide variety of physiological and developmental functions. Traditional steroid hormone signaling acts through nuclear and cytosolic receptors, altering gene transcription and subsequently regulating cellular activity. This is particularly important in hormonally-responsive cancers, where therapies that target classical steroid hormone receptors have become clinical staples in the treatment and management of disease. Much progress has been made in the last decade in detecting novel receptors and elucidating their mechanisms, particularly their rapid signaling effects and subsequent impact on tumorigenesis. Many of these receptors are membrane-bound and lack DNA-binding sites, functionally separating them from their classical cytosolic receptor counterparts. Membrane-bound receptors have been implicated in a number of pathways that disrupt the cell cycle and impact tumorigenesis. Among these are pathways that involve phospholipase D, phospholipase C, and phosphoinositide-3 kinase. The crosstalk between these pathways has been shown to affect apoptosis and proliferation in cardiac cells, osteoblasts, and chondrocytes as well as cancer cells. This review focuses on rapid signaling by 17β-estradiol and 1α,25-dihydroxy vitamin D3 to examine the integrated actions of classical and rapid steroid signaling pathways both in contrast to each other and in concert with other rapid signaling pathways. This new approach lends insight into rapid signaling by steroid hormones and its potential for use in targeted drug therapies that maximize the benefits of traditional steroid hormone-directed therapies while mitigating their less desirable effects.

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Phospholipase A2 activating protein is required for 1α,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3

Cited by 35 publications

References 37 publications

ESWT Enhances Expression of Pdia-3 which is a Key Factor of 1α,25-Dihydroxyvitamin D3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis Knee

ESWT Enhances Expression of Pdia-3 which is a Key Factor of 1α,25-Dihydroxyvitamin D3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis Knee

A review of 1α,25(OH)2D3 dependent Pdia3 receptor complex components in Wnt5a non-canonical pathway signaling

Rapid steroid hormone actions via membrane receptors

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Phospholipase A2 activating protein is required for 1α,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3

Cited by 35 publications

References 37 publications

ESWT Enhances Expression of Pdia-3 which is a Key Factor of 1&alpha;,25-Dihydroxyvitamin D3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis Knee

ESWT Enhances Expression of Pdia-3 which is a Key Factor of 1&alpha;,25-Dihydroxyvitamin D3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis Knee

A review of 1α,25(OH)2D3 dependent Pdia3 receptor complex components in Wnt5a non-canonical pathway signaling

Rapid steroid hormone actions via membrane receptors

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Product

Resources

About

ESWT Enhances Expression of Pdia-3 which is a Key Factor of 1α,25-Dihydroxyvitamin D3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis Knee

ESWT Enhances Expression of Pdia-3 which is a Key Factor of 1α,25-Dihydroxyvitamin D3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis Knee