Phosphodiesterase 4D and 5-lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians

Quarta, Giovanni; Stanzione, Rosita; Evangelista, Anna; Zanda, Bastianina; Angelantonio, Emanuele Di; Marchitti, Simona; Castro, Sara Di; Vavo, Marta Di; Volpe, Massimo; Rubattu, Speranza

doi:10.1038/ejhg.2009.71

Cited by 24 publications

(11 citation statements)

References 35 publications

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“…A detailed account of all these follow-up studies has already been reviewed Yoon et al, 2011). Inflammation has emerged as a key factor in the development of atherosclerotic lesions and in the progression to mature atheroma (Quarta et al, 2009). Further, inflammatory activation promotes thrombosis which is the most dreadful complication of atherosclerosis.…”

Section: Discussionmentioning

confidence: 98%

Association of SNP41, SNP56 and a novel SNP in PDE4D gene with stroke and its subtypes

Munshi

Roy

Thangaraj

et al. 2012

Gene

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Section: Discussionmentioning

confidence: 98%

Association of SNP41, SNP56 and a novel SNP in PDE4D gene with stroke and its subtypes

Munshi

Roy

Thangaraj

et al. 2012

Gene

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][24][25][26] The meta-analysis thus involved a total of 20 populations from 17 publications when our current study was included.…”

Section: Meta-analysismentioning

confidence: 99%

A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene

et al. 2012

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Previous reports have shown ambiguous findings regarding the possible associations between ischaemic stroke (IS) and single nucleotide polymorphisms (SNPs) in the phosphodiesterase 4D (PDE4D) gene region. The SNP rs12188950 (or SNP45) has often been studied in this context. We performed a multi-centre study involving a large sample of 2599 IS patients and 2093 control subjects from the south and west regions of Sweden to replicate previous studies regarding IS risk and rs12188950. Subjects from Lund Stroke Register (LSR), Malmö Diet and Cancer Study (MDC) and Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) were enroled. Subgroups of participants with hypertension and participants o55 years of age, as well as the TOAST subgroups large vessel disease, small vessel disease and cardioembolism, were also assessed. Univariate odds ratios (ORs) and ORs controlling for hypertension, diabetes and current smoking were calculated. We additionally performed a meta-analysis including 10 500 patients and 10 102 control subjects from 17 publications (including the present study). When assessing pooled data from LSR, MDC and SAHLSIS we obtained no association between IS and rs12188950 for all participants (OR¼0.93; 95% confidence interval (CI): 0.83-1.05). Significant associations were not found for hypertensive participants or participants with age o55, or when separately evaluating patients from the three different TOAST subgroups. The meta-analysis showed no significant overall estimate (OR¼0.96; 95% CI: 0.89-1.04) with significant heterogeneity for random effect (P¼0.042). No effect from rs12188950 on IS was found from either our pooled multi-centre data or the performed meta-analysis. We did not find any association between the examined subgroups and rs12188950 either.

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“…However, the results were controversial and conflicting. In particular, a significant association of ischemic stroke with ALOX5AP polymorphisms was found in Scottish[9], German[16], Chinese[14],[17], white American[18], Japanese[19], British[20], Spanish, and Portuguese[21] populations, whereas no evidence of a significant association was reported in different American[22]–[24], Swedish[25],[26], and Italian[27] cohorts.…”

Section: Discussionmentioning

confidence: 84%

Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of ischemic stroke in Han Chinese of eastern China

Wang

Sun

et al. 2011

Journal of Biomedical Research

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Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene have been suggested to play an important role in the pathogenesis of atherosclerosis and ischemic stroke. This study was aimed to explore the association of ALOX5AP variants with ischemic stroke risk in Han Chinese of eastern China. A total of 690 ischemic stroke cases and 767 controls were recruited. The subjects were further subtyped according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. On the basis of that, two polymorphisms of the ALOX5AP gene (rs10507391 and rs12429692) were determined by TaqMan genotyping assay. In addition, plasma leukotriene B4 (LTB4) levels were analyzed in these subjects. There was no evidence of association between the two variants of ALOX5AP and the risk of ischemic stroke or its TOAST-subtypes. Haplotype analysis and stratification analysis according to sex, age, body mass index, hypertension, and diabetes also showed negative association. Analysis of LTB4 levels in a subset of cases and controls revealed that LTB4 levels were significantly higher in ischemic stroke cases than in the controls (70.06±14.75 ng/L vs 57.34±10.93 ng/L; P = 0.000) and carriers of the T allele of the rs10507391 variant were associated with higher plasma LTB4 levels (P = 0.000). The present study suggests there is no association of the two polymorphisms in the ALOX5AP gene with ischemic stroke risk in Han Chinese of eastern China.

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Phosphodiesterase 4D and 5-lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians

Cited by 24 publications

References 35 publications

Association of SNP41, SNP56 and a novel SNP in PDE4D gene with stroke and its subtypes

Association of SNP41, SNP56 and a novel SNP in PDE4D gene with stroke and its subtypes

A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene

Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of ischemic stroke in Han Chinese of eastern China

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