Phosphatidyl-inositol-3-kinase Alpha catalytic subunit kinase domain mutations impart a favorable prognosis on estrogen receptor positive breast cancer through a mechanism that is independent of responsiveness to endocrine treatment.
Abstract:#6060
Background. Mutations in the alpha catalytic subunit of phosphoinositol-3-kinase (PIK3CA) occur in approximately 30% of ER positive breast cancers but the impact of PIK3CA mutation status on the response to endocrine therapy has not been adequately studied.
 Methods. cDNA and genomic DNA derived from baseline formalin-fixed core biopsy specimens from two neoadjuvant endocrine therapy trials (P024 and the letrozole alone arm of the RAD 2222 trial) were sequenced to detect exon 9 … Show more
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