2010
DOI: 10.3816/cbc.2010.s.017
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Biomarkers and Patient Selection for PI3K/Akt/mTOR Targeted Therapies: Current Status and Future Directions

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Cited by 28 publications
(10 citation statements)
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“…Primary candidates include mutations in PIK3CA, PTEN, AKT, as well as overexpression of phosphorylated mTOR and phosphorylated AKT (pAKT). [23][24][25] Preliminary results from a group of patients with advanced solid tumors, including endometrial cancer, harboring PIK3CA mutations that were treated with PI3K/AKT/mTOR inhibitors alone or in combination with other agents, reveals higher than expected response rates (35%) in a highly pretreated group of patients. 26 Interestingly, the presence of KRAS mutations appeared to confer resistance in certain tumor types in the retrospective study by Janku and colleagues.…”
Section: Pathways Of Interest In Endometrial Cancermentioning
confidence: 99%
“…Primary candidates include mutations in PIK3CA, PTEN, AKT, as well as overexpression of phosphorylated mTOR and phosphorylated AKT (pAKT). [23][24][25] Preliminary results from a group of patients with advanced solid tumors, including endometrial cancer, harboring PIK3CA mutations that were treated with PI3K/AKT/mTOR inhibitors alone or in combination with other agents, reveals higher than expected response rates (35%) in a highly pretreated group of patients. 26 Interestingly, the presence of KRAS mutations appeared to confer resistance in certain tumor types in the retrospective study by Janku and colleagues.…”
Section: Pathways Of Interest In Endometrial Cancermentioning
confidence: 99%
“…Samples, where necessary, underwent sodium-acetate/ethanol re-precipitation. We selected 33 genes of interest from key functional nodes in the PIK3CA signaling pathway 60 and 6 reference genes (Supplementary Table 16 , Supplementary Methods section 4). Probes for each gene were designed and synthesized at NanoString Technologies (Washington, USA).…”
Section: Methodsmentioning
confidence: 99%
“…Many relevant molecular abnormalities in endometrial cancer are linked, either in a direct or indirect fashion to the PI3K/AKT/mTOR pathway [17][18][19] . Potential candidates might include PTEN, phospho-AKT, PIK3CA, phospho-mTOR, pS6rp.…”
Section: Discussionmentioning
confidence: 99%