Phosphate Treatment of Idiopathic Calcium Stone Disease

Robertson, William; Heyburn, P. J.; Davies, A. E. J.; Rutherford, Anthony J.

doi:10.1007/978-1-4684-8977-4_43

Cited by 4 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The source is presumed to be the absorbable phosphorus produced from hydrolysis of phytate in the intestine. Peacock et al (1981) reported that oral phosphate treatment (1 g/day) was successful in reducing the recurrence rate in most idiopathic calcium stone formers, and their patients showed increased phosphate excretion and decreased calcium excretion in 24-h urine samples. Thomas Tilden (1 972) suggested that small concentrations of di-and tri-phosphorylated inositol might inhibit the formation of hydroxyapatite crystals in metastable solutions.…”

Section: Discussionmentioning

confidence: 99%

Rice‐bran Treatment for Calcium Stone Formers with Idiopathic Hypercalciuria

Ebisuno

Morimoto

Yoshida

et al. 1986

British Journal of Urology

View full text Add to dashboard Cite

The efficacy of rice-bran therapy was studied in patients with hypercalciuria who were suffering from calcium stones. The frequency of stone episodes was reduced dramatically, especially in "active recurrent stone formers". Urinary calcium excretion was considerably reduced, while urinary phosphate and oxalate were slightly increased. Urinary magnesium, uric acid, serum calcium, phosphate, magnesium and uric acid were not affected. There were no changes in serum iron, copper and zinc even when patients were treated for long periods. The treatment was tolerated well and there were no serious side effects. Rice-bran therapy is particularly useful in patients with hyperabsorptive hypercalciuria and it is effective in the prevention of recurrent urinary stone disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Rice‐bran Treatment for Calcium Stone Formers with Idiopathic Hypercalciuria

Ebisuno

Morimoto

Yoshida

et al. 1986

British Journal of Urology

View full text Add to dashboard Cite

show abstract

“…Approximately 50 to 60% of these patients will demonstrate idiopathic hypercalciuria (Rose and Harrison, 1974). Many studies have reported the successful reduction of urinary calcium excretion and consequent reduction in the incidence of stone formation (Blacklock and Macleod, 1974;Pak et al, 1974;Ljunghall et al, 1980;Peacock et al, 1980). However, no long-term studies have yet shown what happens to those patients with a single episode of stone formation and idiopathic hypercalciuria which has been successfully controlled.…”

mentioning

confidence: 99%

Prostaglandin Synthetase Inhibitors and their Effect on Urinary Calcium Excretion and other Parameters in Idiopathic Hypercalciuria

Shah

Rose

1984

British Journal of Urology

View full text Add to dashboard Cite

The treatment of idiopathic hypercalciuric stone formers with the prostaglandin synthetase inhibitors flurbiprofen and indomethacin has been studied in two phases. Ten patients were studied in a metabolic unit for 14 days that included a control period of 7 days on a controlled intake of dietary calcium, followed by treatment with flurbiprofen 50 mg tds. Three patients were studied along similar lines and were treated with indomethacin 25 mg tds. A significant reduction in urinary calcium excretion was noted during the 7-day control period during which dietary calcium intake was reduced to 700 mg daily. No further significant reduction in urinary calcium excretion was observed during the treatment with either flurbiprofen or indomethacin. Thirteen patients then continued to take flurbiprofen 50 mg tds for between 1 and 12 months. A small but not statistically significant reduction in urinary calcium excretion was noted by the third month of treatment, but this was not sustained. This study confirms the benefit of dietary restriction of calcium as the primary approach to the treatment of idiopathic hypercalciuria. Neither flurbiprofen nor indomethacin reduced urinary calcium excretion to significant levels. Their routine use for the treatment of idiopathic hypercalciuria cannot be recommended from the evidence of this study.

show abstract

Orthophosphates

Caudarella¹

2012

Urolithiasis

View full text Add to dashboard Cite

Phosphate Treatment of Idiopathic Calcium Stone Disease

Cited by 4 publications

References 2 publications

Rice‐bran Treatment for Calcium Stone Formers with Idiopathic Hypercalciuria

Rice‐bran Treatment for Calcium Stone Formers with Idiopathic Hypercalciuria

Prostaglandin Synthetase Inhibitors and their Effect on Urinary Calcium Excretion and other Parameters in Idiopathic Hypercalciuria

Orthophosphates

Contact Info

Product

Resources

About