Phosphataufnahme durch auf dem deutschen Markt befindliche Alleinfutter und Nierendiäten für Hunde und Katzen

Dobenecker, Britta

doi:10.1055/a-1487-8625

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…Besides, phosphate salts permitted as food and feed additives deliver a cation with the phosphate, in this case sodium. The majority of commercially available processed food products for cats supply major minerals in abundance [33,80,81], which makes the mineral profile of this test diet practically relevant.…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, the source of dietary phosphate needs to be considered when formulating diets for CKD patients as well as healthy individuals. Yet, a recent study of Dobenecker (2021) [33] demonstrated that the concentration of phosphate in commercial pet foods, including renal diets, often greatly exceeds the recommended allowance given by the NRC [34] and these diets often contain high percentages of highly water soluble phosphate. A considerable number of products for human consumption are also known to be enriched with inorganic phosphate and are therefore not recommended for kidney patients [26,[35][36][37].…”

Section: Introductionmentioning

confidence: 99%

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The Phosphate Additives Phosphoric Acid and Sodium Phosphate Lead to Hyperphosphatemia as well as Increased FGF23 and Renal Phosphate Excretion in Healthy Cats

2023

J Urol Ren Dis

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Chronic Kidney Disease (CKD) is an increasingly frequent disease in geriatric cats, representing the leading cause of death in this species. Reports about the increasing prevalence of CKD exist also in human medicine. The intake of nutrients, notably phosphorus, can affect renal health. Dietary supply with phosphate can influence concentrations of phosphate and factors of the phosphate homeostasis in blood and urine, possibly causing adverse health effects. Investigating nutritional factors involved in the cause and aggravation of kidney damage in more detail is of high importance not only for feline health. The cat is already successfully used as model for various human diseases which highlights its potential role as translational model for phosphate toxicity in humans. Effects of the food additives H 3 PO 4 and NaH 2 PO 4 on phosphorus homeostasis were investigated in comparison to a control diet. Adding these highly available phosphate additives to the diet of healthy cats for 28 days caused a significant increase in serum phosphate, calcium, and FGF23 as well as in renal phosphorus excretion. Consequently, the use of both phosphate additives in food processing needs to be critically re-evaluated due to the high availability of these sources and therefore their potential adverse health effects. With up to 80 % prevalence, Chronic Kidney Disease (CKD) is one of the most common chronic diseases in geriatric cats [1,2], and represents the leading cause of death in this species [3]. Reports of the increasing prevalence of CKD in the last decades also exist in human medicine [4]. It has been shown in various species, including humans and cats, that the supply of nutrients, notably phosphorus, can affect renal health [5][6][7]. To investigate nutritional factors involved in cause and aggravation of kidney damage in more detail is therefore of high importance not only for feline health. The fact that the cat has been successfully used as a model for human diseases in several studies [8][9][10][11][12] supports its potential role as translational model for human medicine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Phosphate Additives Phosphoric Acid and Sodium Phosphate Lead to Hyperphosphatemia as well as Increased FGF23 and Renal Phosphate Excretion in Healthy Cats

2023

J Urol Ren Dis

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“…Inorganic salts of phosphoric acid and phosphorus from bones and cartilage, i.e., ‘organic’ phosphates from carcass meal and bone meal, were given in amounts similar to those used in the study of Dobenecker et al [ 37 ]. Total phosphorus amounts of this magnitude can also be found in pet food products on the market [ 45 ]. Inorganic phosphates are used in processed feed products for technical purposes, including water binding, preservation, texture, colour, and palatability enhancement.…”

Section: Discussionmentioning

confidence: 99%

The Source Matters–Effects of High Phosphate Intake from Eight Different Sources in Dogs

Dobenecker

Kienzle

Siedler

2021

Animals

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Elevated serum phosphate concentrations are an established risk factor for cardiovascular disease and mortality in chronic kidney disease in various species. Independent associations of other parameters of phosphorus metabolism, such as phosphorus intake from different sources and serum concentrations of phosphorus, as well as parameters involved in the regulation, such as parathyroid hormone (PTH) or markers of bone turnover, have been studied in less detail. Therefore, the serum kinetics of phosphate, PTH, and the bone resorption marker bone-specific alkaline phosphatase (BAP) were investigated after 18 days of feeding a control diet and diets supplemented with eight different organic and inorganic phosphate sources aiming at 1.8% phosphorus per dry matter and calcium to phosphorus ratio between 1.3 and 1.7 to 1. Eight healthy beagle dogs (f/m, 2–4 years, 12.9 ± 1.4 kg body weight) were available for the trial. Highly significant differences in the serum kinetics of phosphorus, PTH, and BAP with the highest postprandial levels after feeding highly water-soluble sodium and potassium phosphates were found. We conclude that the use of certain inorganic phosphates in pet food is potentially harmful and should be restricted.

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High Intake of Sodium Chloride for 28 Days Causes No Effect on Serum FGF23 Concentrations in Cats

Steffen

Kienzle

Dobenecker

2022

Animals

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Background: FGF23 is an acknowledged parameter to assess kidney health. As chronic kidney failure is one of the most common diseases in aging cats, dietary influences on renal health warrant investigation. The purpose of this study was therefore to investigate potential correlations between dietary sodium chloride and FGF23. Methods: In a total of two trials, 11 cats were included. In the first trial, the cats were fed a complete and balanced control diet; in the second trial, sodium chloride was added (8 g/kg/DM)). Blood, urinary, feed, and faecal samples were analysed for major minerals. FGF23 and creatinine were measured in blood and urine samples. Results: Serum phosphate and FGF23 were unaffected by high sodium chloride intake, thus showing no correlation between serum FGF23 and sodium concentrations. Apparent phosphorus digestibility was significantly increased, however, by high sodium chloride intake, whereas apparent digestibility of calcium was unaffected. The present study confirms differences in FGF23 and sodium chloride interaction in cats compared with other species. Further research regarding the correlation between sodium chloride and phosphate homeostasis is warranted.

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Phosphataufnahme durch auf dem deutschen Markt befindliche Alleinfutter und Nierendiäten für Hunde und Katzen

Cited by 3 publications

References 37 publications

The Phosphate Additives Phosphoric Acid and Sodium Phosphate Lead to Hyperphosphatemia as well as Increased FGF23 and Renal Phosphate Excretion in Healthy Cats

The Phosphate Additives Phosphoric Acid and Sodium Phosphate Lead to Hyperphosphatemia as well as Increased FGF23 and Renal Phosphate Excretion in Healthy Cats

The Source Matters–Effects of High Phosphate Intake from Eight Different Sources in Dogs

High Intake of Sodium Chloride for 28 Days Causes No Effect on Serum FGF23 Concentrations in Cats

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