“…Inhibins and Activin A also exert opposing effects on several cells of the hematopoietic lineage, including erythroid, (Yu, et al 1987) megakaryocyte, (Fujimoto, et al 1991; Okafuji, et al 1995), granulocyte-macrophage lineage cells (Broxmeyer, et al 1988; Scher, et al 1990), as well as cells of the monocyte/macrophage lineage (Yamada, et al 1992; Fuller, et al 2000; Gaddy-Kurten, et al 2002; Perrien, et al 2006). Activin βA subunit mRNA is locally produced in bone marrow; (Yu, et al 1994) and, like TGFβ (Bonewald and Mundy 1990) and bone morphogenetic proteins (BMPs) (Wozney 1992), Activin A protein is abundantly localized in the bone matrix (Ogawa, et al 1992).…”