Phomanones A-C From Phoma sp. HDN16-618: A Mariana Trench Fungus

Abstract

Three new compounds, phomanones A-C (1-3), and a known compound, 2-hydroxymethyl-3-methylcyclopent-2-enone (4), were isolated from Phoma sp. HDN16-618, a fungus derived from a sea water sample collected from Mariana Trench. Their structures, including absolute configurations, were elucidated by extensive Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), and electronic circular dichroism analyses. None of the compounds showed significant cytotoxic activity against a panel of cancer cell lines.

Fruitful Decade of Phoma Secondary Metabolites from 2011 to 2020: Chemistry, Chemical Diversity, and Biological Activities

“…Phomanones B (13) and 14 were reported from Phoma sp. but were inactive toward K562, HL-60, HCT-116, BEL-7402, A549, HeLa, L-02, SH-SY5Y, HO8910, PC-3, U87, MGC-803, and MDA-MB-231 cancer cells (Lu et al 2019).…”