Fruitful Decade of Phoma Secondary Metabolites from 2011 to 2020: Chemistry, Chemical Diversity, and Biological Activities

Hussain, Hidayat; Elizbit,; Ali, Iftikhar; Mamadalieva, Nilufar Z.; Abbas, Ghulam; Ali, Maroof; Zaman, Gohar; Khan, Amjad; Hassan, Uzma; Green, Ivan R.

doi:10.1007/978-3-030-81218-8_10

Cited by 2 publications

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References 52 publications

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“…Furthermore, the effects of endophyte-derived compounds with antibacterial activities on antibiotic-resistant bacteria have not been sufficiently studied. Another limitation is that the potential impacts of substances with anticancer properties on normal cells have not been adequately explored [ 22 , 23 , 24 , 25 , 26 , 27 ]. In many cases, these limitations arise from the difficulty in isolating pure active substances from endophytes and the low yields of the resultant compounds—issues that are further complicated by the fact that some of the compounds are synthesized only during a limited phase of the endophytes’ life cycle [ 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms

Eshboev,

Mamadalieva,

Nazarov

et al. 2024

Antibiotics

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Infectious diseases are a significant challenge to global healthcare, especially in the face of increasing antibiotic resistance. This urgent issue requires the continuous exploration and development of new antimicrobial drugs. In this regard, the secondary metabolites derived from endophytic microorganisms stand out as promising sources for finding antimicrobials. Endophytic microorganisms, residing within the internal tissues of plants, have demonstrated the capacity to produce diverse bioactive compounds with substantial pharmacological potential. Therefore, numerous new antimicrobial compounds have been isolated from endophytes, particularly from endophytic fungi and actinomycetes. However, only a limited number of these compounds have been subjected to comprehensive studies regarding their mechanisms of action against bacterial cells. Furthermore, the investigation of their effects on antibiotic-resistant bacteria and the identification of biosynthetic gene clusters responsible for synthesizing these secondary metabolites have been conducted for only a subset of these promising compounds. Through a comprehensive analysis of current research findings, this review describes the mechanisms of action of antimicrobial drugs and secondary metabolites isolated from endophytes, antibacterial activities of the natural compounds derived from endophytes against antibiotic-resistant bacteria, and biosynthetic gene clusters of endophytic fungi responsible for the synthesis of bioactive secondary metabolites.

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