Phoenix dactylifera protects against oxidative stress and hepatic injury induced by paracetamol intoxication in rats

Salem, Gamal A.; Shaban, Ahmed; Diab, Hussain A.; Elsaghayer, Wesam; Mjedib, Manal D.; Hnesh, Aomassad M.; Sahu, Ravi P.

doi:10.1016/j.biopha.2018.05.049

Cited by 42 publications

(25 citation statements)

References 64 publications

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“…Moreover, SAFE treatment also increased CAT activity and T-AOC level, as well as decreasing MDA level. These results proved that SAFE attenuated APAP-induced liver injury by alleviating oxidant stress and improving antioxidant enzymes activity, which were also in accordance with other reports [33, 70, 71].…”

Section: Discussionsupporting

confidence: 93%

The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice

Liu

Luo

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Acute liver injury is a common consequence of taking overdose of acetaminophen (APAP). The aim of this study was to evaluate the antioxidant activity and hepatoprotective effect of a mangrove plant Sonneratia apetala fruit extract (SAFE) on APAP-induced liver injury in mice. Mice were orally pretreated with SAFE (100, 200, and 400 mg/kg) daily for one week. The control and APAP groups were intragastrically administered with distilled water, and NAC group was treated with N-Acetyl-L-cysteine (NAC) before APAP exposure. The results manifested that SAFE significantly improved survival rates, attenuated hepatic histological damage, and decreased the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in serum in APAP-exposed mice. SAFE treatment also increased glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity, enhanced catalase (CAT), and total antioxidant capacity (T-AOC), as well as reducing malondialdehyde (MDA) level in liver. In addition, the formation of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and elevation of myeloperoxidase (MPO) in APAP-exposed mice were inhibited after SAFE treatment. And SAFE also displayed high DPPH radical scavenging activity and reducing power in vitro. The main bioactive components of SAFE such as total phenol, flavonoid, condensed tannin, and carbohydrate were determined. The current study proved that SAFE exerted potential protective effect against APAP-induced acute liver injury, which might be associated with the antioxidant and anti-inflammatory activities of SAFE.

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Section: Discussionsupporting

confidence: 93%

The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice

Liu

Luo

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…These remedial effects of (TE.AQ) extract are due to the antioxidant activity and lysosomal membrane stabilization. These effects were comparable to silymarine treated group, a stander hepatoprotective agent (Salem, Shaban et al, 2018). Similar study was also conducted by (Safaei i et al, 2018) who studied the protective effect of Parthenium Hysterophorus against CCL4 and paracetamol induced toxicity.…”

Section: Discussionsupporting

confidence: 79%

Untitled

2021

Pak. J. Pharm. Sci

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Present study is aimed to investigate the hepatoprotective and hematopoietic effect of Typha elephantina leaves aqueous (T.E.AQ), extract in paracetamol (PCM) intoxicated rabbits. Experimental animals were divided into various groups. The blood was taken on day 7 th (W1=Week 1), day 14 th (W2 = week 2) and day 21 st (W3 = week 3) of treatments and was analyzed for all hematological and serum biochemical markers. PCM administration caused marked increase in the levels of serum biochemical and hematological parameters. The leaves of T.E.AQ extract at dose rate 300mg/kg body weight significantly (P<0.05) reduced the elevated levels of serum biochemical and hematological indices towards normal values on third week (day 21 st ) of treatment while treatment in the first two weeks revealed nonsignificant effects even at all doses of extract. The levels of glutathione (GSH) and radical scavenging activity (RSA) were reduced and thiobarbituric acid reactive substances (TBARS) levels was high in the PCM feed animals. Administration of (T.E.AQ) extract at high dose (300mg/kg) significantly regulated and normalized these antioxidant values. The antioxidant capacity of (TE.AQ) extract, showed increase inhibition against various extract concentrations on the basis of percent scavenging of (DPPH) free radical. The histological sections of liver further supported the hepatoprotective activity of extract.

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“…The protective effect of DPL methanolic extract against paracetamol-induced hepatotoxicity in albino rats has been reported [13]; the extract potentially reduced the elevated levels of catalase, superoxide dismutase, and glutathione peroxidase.…”

Section: Introductionmentioning

confidence: 95%

Towards the Utilization of Date Palm (<i>Phoenix dactylifera</i>) Leaves as a Rich Source of Antioxidants

Abuelgassim¹

2020

JFNR

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Three varieties of date palm (Phoenix dactylifera) leaves (DPL) namely: Sagaie, Khalas, and Nabtat Alsaif were examined for their antioxidant activities. DPL extracts showed a total phenolic content ranged between 1498.14 ± 100.52-4374.76 ± 657.64 mg gallic acid equivalent (GAE)/100g dry weight (DW) and a total flavonoid ranged between 134.70 ± 16.24-224.62 ± 22.35 mg quercetin (QE)/100g (DW). The IC 50s for scavenging ABTS radical were ranged between 71.87 ± 14.37-217.87 ± 27.40µg Trolox equivalent, whereas that required for scavenging DPPH were ranged between 197.86 ± 17.60-693.32 ± 25.44 µg ascorbic acid equivalent. DPL extracts potentially scavenged hydroxyl and superoxide anion radicals, IC 50s values were ranged between 208.04 ± 12.76-719.63 ± 24.38 and 825.92 ± 19.40-1193.20 ± 28.74µg GAE respectively. DPL extracts showed a good activity against ferric reducing antioxidant power (FRAP) ranged between 7.69 ± 0.47-22.13 ± 1.36 mmol ascorbic acid equivalent/100g. DPL extracts showed a considerable antioxidant activity, therefore, DPL could be effectively used as natural source of antioxidant in food and pharmaceutical industries.

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Phoenix dactylifera protects against oxidative stress and hepatic injury induced by paracetamol intoxication in rats

Cited by 42 publications

References 64 publications

The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice

The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice

Untitled

Towards the Utilization of Date Palm (<i>Phoenix dactylifera</i>) Leaves as a Rich Source of Antioxidants

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