Phlyctenulae and Catarrhal Infiltrates

Mondino, Bartly J.

doi:10.1001/archopht.1982.01030040948017

Cited by 29 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ocular redness might be related to bacterial toxin production. Phlyctenules and corneal infiltrates are thought to be caused by a type IV cell-mediated delayed hypersensitivity reaction against parietal staphylococcal antigens [5]. In addition to its antibiotic effect, azithromycin also has anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 99%

“…Staphylococcal infection in the meibomian glands is probably secondary and may induce conjunctival and corneal inflammation by a T lymphocyte immune response against bacterial parietal antigens or toxins. The phlyctenules and corneal infiltrates are the result of a type IV cell-mediated late hypersensitivity reaction according to the Gell and Coombs' classification [5]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of azithromycin 1.5% eye drops in childhood ocular rosacea with phlyctenular blepharokeratoconjunctivitis

Doan

Gabison

Chiambaretta

et al. 2013

J OPHTH INFLAMM INFECT

View full text Add to dashboard Cite

BackgroundThe purpose of this study is to report the efficacy of azithromycin 1.5% eye drops in children with ocular rosacea and phlyctenular blepharokeratoconjunctivitis. This retrospective study from January 2009 to March 2010 included 16 children treated with lid hygiene plus azithromycin 1.5% eye drops (Azyter®): 3-day treatments (1 drop twice a day) every 10 days, reduced based on efficacy to one treatment every 15 days and then to one treatment per month.ResultsNineteen eyes of six boys and ten girls, aged 4 to 16 years (mean, 9.3 ± 4.0) were included. The disease was previously resistant to lid hygiene (all the patients), oral erythromycin (one patient), and intermittent topical steroids (six patients). The median duration of each phase of azithromycin treatment (i.e., three, two, and one treatments per month) was 2 months. Ocular inflammation was controlled by azithromycin alone in 15 patients. In one uncontrolled case, cyclosporine 2% eye drops was added at month 5. Bulbar conjunctival hyperemia resolved completely within 1 month in all eyes, whereas conjunctival phlyctenules and corneal inflammation took longer to improve, with a complete resolution within 3 to 10 months. Blepharitis grade decreased from 2.31 ± 0.79 to 1.50 ± 0.73. Treatment was stopped after a median of 6 months (from 4 to 10 months) without recurrence of corneoconjunctival inflammation (median follow-up without treatment, 11 months). Six cases of ocular irritation were reported, two of which led to treatment withdrawal.ConclusionAzithromycin 1.5% eye drops is an effective treatment for phlyctenular keratoconjunctivitis complicating childhood ocular rosacea.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of azithromycin 1.5% eye drops in childhood ocular rosacea with phlyctenular blepharokeratoconjunctivitis

Doan

Gabison

Chiambaretta

et al. 2013

J OPHTH INFLAMM INFECT

View full text Add to dashboard Cite

show abstract

“…Eine weitere Indikation für eine Kombinationstherapie stellt die periphere Randkeratitis dar. Die kornealen Infiltrate sind Hypersensititivitäts-reaktionen vom verzögerten Typ auf Bakterien -insbesondere auf Staphylokokken[17,35]. Die postoperative Therapie nach intra-und extraokularen Eingriffen wird in der Regel kombiniert durchgeführt -primär mit der Steroidkomponente zur Hemmung der Inflammation durch Prostaglandine, sekundär mit dem Antibiotikum zur Infektionsprophylaxe.…”

unclassified

Antiinfektive medikamentöse Therapie in der Augenheilkunde - Teil 1: Bakterielle Infektionen

Behrens–Baumann

2004

Klin Monatsbl Augenheilkd

View full text Add to dashboard Cite

This review presents a rational antibacterial therapy. First, systemic versus topical administration of the drugs is discussed including substances specific for the respective routes. Secondly, ocular diseases requiring systemic therapy are presented followed by a discussion of infections suitable for topical administration. Finally, the pros and cons of a combined antibiotic-steroid therapy are discussed and examples described.

show abstract