Immune Responses in Rabbits With Phlyctenules and Catarrhal Infiltrates

Phenotypic characterization of inflammatory cells in phlyctenular eye disease

“…Other causes involved in the pathogenesis of the disease are candida albicans, coccidioides immitis, the agent of lymphogranuloma venereum [4], ascariasis [5], helminthiasis [6], and Hymenolepis nana [7]. In recent years it has been demonstrated experimentally that hypersensitivity to staphylococcal cell walls could evoke the disease [8,9].…”

Phenotypic characterization of inflammatory cells in phlyctenular eye disease

“…Other causes involved in the pathogenesis of the disease are candida albicans, coccidioides immitis, the agent of lymphogranuloma venereum [4], ascariasis [5], helminthiasis [6], and Hymenolepis nana [7]. In recent years it has been demonstrated experimentally that hypersensitivity to staphylococcal cell walls could evoke the disease [8,9].…”

Immunocytological study of phlyctenular eye disease

“…This protein is considered to be responsible for the development of phlyctens in a large number of clinical cases. Experimental phlyctenulosis and catarrhal infiltrates have been produced in rabbits by immunizing the animals with phenol inactivated staphylococcus aureus or with staphylococcus cell walls, followed by topical challenge with viable staphylococcus aureus, suggesting that hypersensitivity to the bacterial cell walls was responsible for producing these lesions (14,15). These polysac- charides may gain access to the corneal stroma and conjunctival tissue through an epithelial abrasion and combine with specific antibodies that are present there or attracted from limbal vessels (5).…”

Phenotypic characterization of inflammatory cells in phlyctenular eye disease

“…Other causes involved in the pathogenesis of the disease are candida albicans, coccidioides immitis, the agent of lymphogranuloma venereum [4], ascariasis [5], helminthiasis [6], and Hymenolepis nana [7]. In recent years it has been demonstrated experimentally that hypersensitivity to staphylococcal cell walls could evoke the disease [8,9].…”

Immunocytological study of phlyctenular eye disease

“…This protein is considered to be responsible for the development of phlyctens in a large number of clinical cases. Experimental phlyctenulosis and catarrhal infiltrates have been produced in rabbits by immunizing the animals with phenol inactivated staphylococcus aureus or with staphylococcus cell walls, followed by topical challenge with viable staphylococcus aureus, suggesting that hypersensitivity to the bacterial cell walls was responsible for producing these lesions (14,15). These polysac- charides may gain access to the corneal stroma and conjunctival tissue through an epithelial abrasion and combine with specific antibodies that are present there or attracted from limbal vessels (5).…”

Phenotypic characterization of inflammatory cells in phlyctenular eye disease

“…Other causes involved in the pathogenesis of the disease are candida albicans, coccidioides immitis, the agent of lymphogranuloma venereum [4], ascariasis [5], helminthiasis [6], and Hymenolepis nana [7]. In recent years it has been demonstrated experimentally that hypersensitivity to staphylococcal cell walls could evoke the disease [8,9].…”

Immunocytological study of phlyctenular eye disease

“…This protein is considered to be responsible for the development of phlyctens in a large number of clinical cases. Experimental phlyctenulosis and catarrhal infiltrates have been produced in rabbits by immunizing the animals with phenol inactivated staphylococcus aureus or with staphylococcus cell walls, followed by topical challenge with viable staphylococcus aureus, suggesting that hypersensitivity to the bacterial cell walls was responsible for producing these lesions (14,15). These polysac- charides may gain access to the corneal stroma and conjunctival tissue through an epithelial abrasion and combine with specific antibodies that are present there or attracted from limbal vessels (5).…”