Phloroglucinol and Its Derivatives: Antimicrobial Properties toward Microbial Pathogens

Khan, Fazlurrahman; Tabassum, Nazia; Bamunuarachchi, Nilushi Indika; Kim, Young‐Mog

doi:10.1021/acs.jafc.2c00532

Cited by 18 publications

(10 citation statements)

References 191 publications

(316 reference statements)

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“…Phloroglucinol and its acylphloroglucinol derivatives have shown promising anti-MRSA action. They prevent such drug resistance by disturbing bacterial inner membrane permeability [36]. Indole-based natural compound epidithiodioxopiperazine have also demonstrated significant bactericidal action against MRSA [37].…”

Section: Natural Productsmentioning

confidence: 99%

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

et al. 2022

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There are several bacteria called superbugs that are resistant to multiple antibiotics which can be life threatening specially for critically ill and hospitalized patients. This article provides up-to-date treatment strategies employed against some major superbugs, like methicillin-resistant Staphylococcus aureus, carbapenem-resistant Enterobacteriaceae, vancomycin-resistant Enterococcus, multidrug-resistant Pseudomonas aeruginosa, and multidrug-resistant Escherichia coli. The pathogen-directed therapeutics decrease the toxicity of bacteria by altering their virulence factors by specific processes. On the other hand, the host-directed therapeutics limits these superbugs by modulating immune cells, enhancing host cell functions, and modifying disease pathology. Several new antibiotics against the global priority superbugs are coming to the market or are in the clinical development phase. Medicinal plants possessing potent secondary metabolites can play a key role in the treatment against these superbugs. Nanotechnology has also emerged as a promising option for combatting them. There is urgent need to continuously figure out the best possible treatment strategy against these superbugs as resistance can also be developed against the new and upcoming antibiotics in future. Rational use of antibiotics and maintenance of proper hygiene must be practiced among patients.

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Section: Natural Productsmentioning

confidence: 99%

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

et al. 2022

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“…It was also demonstrated that DAPG modulates auxin-dependent plant signaling pathway leading to significant modifications of plant root development [31][32][33]. Moreover, following an exposition of DAPG, the germination as well as the development of different crop plants were severely impacted [31,34,35]. Nevertheless, this herbicidal effect remains variable according to the plant species and was observed following the exposure of high concentrations that do not reflect those produced in vivo.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of broomrape germination by 2,4-diacetylphloroglucinol produced by environmentalPseudomonas

Lurthy

Perot

Gerin-Eveillard

et al. 2023

Preprint

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Phloroglucinol compounds (PGCs) produced by environmentalPseudomonasare well known for their capacity to limit plant-pathogen infection. Although PGCs and more specifically 2,4-diacetylphloroglucinol (DAPG) are well studied for their antimicrobial properties, they are to some extent toxic for crop plants. Parasitic weeds such as broomrapes (Phelipanche ramosaandOrobanche cumana) cause severe damage to crops and their development must be controlled. Here, we assessed the potential herbicidal effect of the bacterial modelPseudomonas ogaraeF113, a PGCs-producing bacterium, on parasitic weed germination. We show using a mutagenesis approach that PGCs produced in bacterial supernatants are the main determinant inhibiting the germination of broomrapes. The use of individual or cocktails of pure PGCs revealed that the inhibition of the germination depends on the PGCs molecular structure and their concentrations as well as the broomrape species and pathovars. Furthermore, the inhibition caused by the PGCs is irreversible, causing a brown coloration of the broomrape seeds. Then, we evaluated in non-sterile soils the ability of bacterial inoculants or chemical DAPG to limit the infection of broomrapes on oil seed rape. Only the inoculation of PGCs-producing bacteria limited the infection ofP. ramosa. Moreover, elemental profiling analysis of oil seed rape revealed that neither the inoculant nor applied DAPG affected the nutrition capacity of the oil seed rape. Our study expands the knowledge on the role that these multi-talented plant-beneficialPseudomonasplay in the environment and open new avenues for the development of natural bioherbicides to ward off parasitic plant infection.

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“…Plant bacterial diseases, such as kiwifruit bacterial canker, carrot soft rot, and rice bacterial blight, are some of the most important causes of the decrease in the quality and quantity of crops. They are exceedingly difficult to manage in agricultural production 1–3 . Currently, the prevention and treatment of plant bacterial diseases rely mainly on traditional commercial bactericides.…”

Section: Introductionmentioning

confidence: 99%

“…They are exceedingly difficult to manage in agricultural production. [1][2][3] Currently, the prevention and treatment of plant bacterial diseases rely mainly on traditional commercial bactericides. However, modern agriculture requires the production of high-quality produce.…”

Section: Introductionmentioning

confidence: 99%

Discovery of diversified cassane diterpenoids as potent antibacterial agents from Caesaplinia pulcherrima and their mechanisms

Chen

Wang

Zhang

et al. 2023

Pest Management Science

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BACKGROUND Natural products play a significant role in the development of novel bactericide candidates. Caesalpinia pulcherrima, a traditional medicine, had anti‐inflammatory, antimicrobial, and antifeedant activities, therefore the previous bioassay results of C. pulcherrima implied that its main active ingredients may have potential to be used as botanical bactericides. RESULTS Bio‐guided isolation of C. pulcherrima was conducted to obtain 11 novel cassane diterpenoids (capulchemins A–K) and 10 known sesquiterpenes. Their structures were established by extensive spectroscopic methods and single‐crystal X‐ray diffraction analyses. Capulchemins A–F possess a rare aromatic C ring, while capulchemin K with a 15,16‐degradative carbon skeleton represents a rare group of cassane diterpenes. Capulchemin A exhibited remarkable antibacterial activity against four phytopathogenic bacteria, particularly against Pseudomonas syringae pv. actinidae and Bacillus cereus, with minimal inhibitory concentration values of 3.13 μM. Meanwhile, capulchemin A showed significant control effect on kiwifruit canker in vivo. Further investigation of its mechanism of antibacterial activity revealed that compound 1 was closely related to destroy cell membrane to cause cell death. Additionally, some of those cassane diterpenoids showed potential antifeedant against Mythimna separate walker and Plutella xylostella. Consequently, capulchemin A could have the potential to be used as a template for the development for new eco‐friendly NP‐based bactericides. CONCLUSION These data contribute to a better understanding of the antibacterial activity of cassane diterpenes. Cassane diterpenes have been discovered to be leading to broad application prospects in the development as novel botanical bactericides. © 2023 Society of Chemical Industry.

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Phloroglucinol and Its Derivatives: Antimicrobial Properties toward Microbial Pathogens

Cited by 18 publications

References 191 publications

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

Inhibition of broomrape germination by 2,4-diacetylphloroglucinol produced by environmentalPseudomonas

Discovery of diversified cassane diterpenoids as potent antibacterial agents from Caesaplinia pulcherrima and their mechanisms

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