Pheochromocytoma in Dogs and Cats

Maher, Edward; McNiel, Elizabeth A.

doi:10.1016/s0195-5616(97)50037-4

Cited by 49 publications

(67 citation statements)

References 27 publications

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“…Adrenalectomy is technically demanding because of difficulties in exposing the adrenal glands and the proximity and possible involvement of adjacent vascular structures such as the caudal vena cava and renal vein. [11][12][13] A midline laparotomy was performed to permit full examination of the abdominal cavity, including examination of both adrenal glands and examination for intra-abdominal metastases. A paracostal approach for adrenalectomy has been described but provides limited exposure of the abdominal viscera.…”

mentioning

confidence: 99%

Nontraumatic rupture of an adrenal gland tumor causing intra-abdominal or retroperitoneal hemorrhage in four dogs

Whittemore¹,

Preston²,

Kyles³

et al. 2001

javma

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Diagnosis and surgical management of intra-abdominal or retroperitoneal hemorrhage in 4 dogs with rupture of an adrenal gland tumor were determined. All 4 dogs were lethargic and weak with pale mucous membranes on initial examination. Three dogs did not have any history of clinical signs of hyperadrenocorticism or pheochromocytoma prior to examination. In 3 of the dogs, a mass in the area of the adrenal gland was identified with ultrasonography prior to surgery. All dogs developed ventricular premature contractions before or during anesthesia. Three dogs survived adrenalectomy; 1 dog was euthanatized during surgery because of an inability to achieve adequate hemostasis. The remaining 3 dogs all survived more than 5 months after surgery; 1 was euthanatized 9 months after surgery because of rupture of a hepatic mass. On the basis of these results, we suggest that hemodynamic stabilization followed by adrenalectomy is the treatment of choice for dogs with nontraumatic rupture of an adrenal gland tumor and resulting life-threatening hemorrhage.

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confidence: 99%

Nontraumatic rupture of an adrenal gland tumor causing intra-abdominal or retroperitoneal hemorrhage in four dogs

Whittemore¹,

Preston²,

Kyles³

et al. 2001

javma

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“…PBZ non-competitively binds to α-adrenergic receptors, which undergo irreversible alkylation and inhibition. In doing so, PBZ non-competitively inhibits adrenaline and noradrenaline from effecting life-threatening vasoconstriction and hypertension (Maher and McNiel 1997). The exact duration of action in dogs has yet to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Management of life‐threatening hypertension in a 12‐year‐old bichon frise undergoing an adrenalectomy for phaeochromocytoma excision

Ferreira

Raszplewicz

2016

Vet Record Case Reports

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A bichon frise, previously diagnosed with a phaeochromocytoma, underwent phenoxybenzamine treatment 17 days before adrenalectomy. Preoperative haematology, biochemistry and oscillometric blood pressure readings for the 12 year old were typical. Before anaesthesia, methadone and medetomidine were administered intramuscularly. Anaesthesia was induced using propofol titrated to permit endotracheal intubation and maintenance of anaesthesia using an isoflurane in oxygen mixture. Invasive blood pressure monitoring by a cannula in a dorsal pedal artery promptly revealed life-threatening hypertension. Rapid increase in isoflurane concentration, multiple intravenous fentanyl boluses administration and commencement of an esmolol citrate infusion were unsuccessful in attenuating the hypertension observed. Rapid rises in end-tidal carbon dioxide and resultant tachypnoea necessitated atracurium intravenously and positive pressure ventilation. Hypertension was eventually abolished using intravenous acepromazine, which ultimately caused a hypotensive nadir. Reduction in anaesthetic depth and aggressive fluid therapy resolved hypotension before termination of anaesthesia. Management of hypertension in dogs with phaeochromocytoma remains challenging.

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“…6 These tumors may be both locally invasive and metastatic. 2 It is thought that negative feedback of NE on tyrosine hydroxylase (which converts tyrosine to dopa, leading to synthesis of more NE) does not work normally in the tumor cells, or that the tumor metabolizes NE so quickly that the levels required for negative feedback are never reached. 2 It is thought that negative feedback of NE on tyrosine hydroxylase (which converts tyrosine to dopa, leading to synthesis of more NE) does not work normally in the tumor cells, or that the tumor metabolizes NE so quickly that the levels required for negative feedback are never reached.…”

mentioning

confidence: 99%

“…3,5 Most pheochromocytomas in humans secrete norepinephrine (NE) (versus epinephrine), but this has not been studied in dogs or cats. 2 2 …”

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confidence: 99%