Pheochromocytoma, Adrenal Medulla, Mouse

Mouse

“…Diffuse changes involve an increase in the number and volume of all the medullary cells. (Capen et al 2001, Faccini et al 1990, Frith 1983b, Frith & Ward 1988, Frith et al 2007, Nyska & Maronpot 1999, Tischler & Sheldon 1996.…”

Comparative Studies of Chromaffin Cell Proliferation in the Adrenal Medulla of Rats and Mice

“…Pheochromocytomas occur spontaneously with reported lifetime frequencies of 3% or less in most studies involving mice, and their frequency is usually not affected by xenobiotic agents (Frith, 1983;Longeart, 1996;Tischler and Sheldon, 1996). Substances that induce pheochromocytomas in rats are pharmacologically diverse and, for the most part, nongenotoxic.…”