Phenylpropanoids and Fatty Acids Levels in Roots and Leaves of Datura Stramonium and Datura Innoxia

Rahmoune, Bilal; Zerrouk, Izzeddine Zakarya; Morsli, Abdelkader; Slaoui, Madjda Khelifi; Khelifi, Lakhdar; Amarante, Luciano do

doi:10.22159/ijpps.2017v9i7.15946

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…They revealed that in both the Datura species, phenylpropanoids composition in leaves was remarkably higher than in the roots. However; fatty acids (hexadecanoic acid and octadecanoic acid) are observed in almost equal rate between leaves and roots [39]. To the best of our knowledge, the present investigation is the first report of the detection and quantification of these two hydroxycinnamic acids (chlorogenic and caffeic acid) from the root and seed parts of Datura spp.…”

Section: Discussionmentioning

confidence: 60%

Comparative Analysis of Morphology and Phytochemical Constituents in Different Populations and Morphotypes of Datura Innoxia Mill. And Datura Metel L. From Punjab Plains

Partap

Gupta

Pradhan

2019

Asian J Pharm Clin Res

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Objective: Comparative analysis of morphology and phytochemical constituents in different populations and morphotypes of Datura innoxia Mill. and Datura metel L. from Punjab plains.Methods: Morphological analyses of different populations have been done. Methanol extracts of seeds and roots of different populations have been prepared and total phenols, flavonoid contents were measured through spectrophotometry. Antioxidant activity was studied by 2, 2-diphenyl-1- picrylhydrazyl radical scavenging activity and total antioxidant capacity. Two major compounds, caffeic acid and chlorogenic acid were quantified by high-performance thin-layer chromatography (HPTLC) analyses.Results: Two morphotypes of D. metel were reported in the present study. Out of five different populations of D. metel and D. innoxia, the wild populations have more bioactive compound as compared to the cultivated ones from the detailed phytochemical investigation. Pharmacologically important two marker compounds chlorogenic acid and caffeic acid has been identified and quantified by HPTLC technique.Conclusion: Variation in terms of morphology and secondary metabolites exists among the different populations of Datura spp. Among the two plant parts studied, seeds have the maximum amount of bioactive metabolites and antioxidant activity. This study revealed that chlorogenic acid and caffeic acid are the potential polyphenolic compounds in Datura spp. It has been found that the antioxidant activity of plant is due to its polyphenol contents, which provides insight to various researchers to work on it as it imparts health benefit.

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Section: Discussionmentioning

confidence: 60%

Comparative Analysis of Morphology and Phytochemical Constituents in Different Populations and Morphotypes of Datura Innoxia Mill. And Datura Metel L. From Punjab Plains

Partap

Gupta

Pradhan

2019

Asian J Pharm Clin Res

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“…Octadecanoic acid or stearic acid is a saturated fatty acid found in relatively high concentrations in some foods. Octadecanoic acid or stearic acid is the primary metabolites present in plants which form of glycerol esters [30]. Stearic acid has been reported to inhibit the development of human breast cancer cells in proliferation in vitro [31][32][33] and in vivo [34].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Cytotoxic Activity of Rodent Tuber Mutant Plant (Typhonium Flagelliforme Lodd.) Against to McF-7 Breast Cancer Cell Line

Sianipar

Assidqi

Purnamaningsih

et al. 2019

Asian J Pharm Clin Res

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Objective: The objective of this study was to determine the new bioactive compounds through gas chromatography–mass spectrometry analysis and the cytotoxic activity of two rodent tuber mutant plants against breast cancer cells (MCF-7). Methods: The bioactive compounds in rodent tuber mutant plants were successfully increased by somaclonal variation using gamma rays irradiation technique. Further, the cytotoxicity activity of rodent tuber mutant plants was tested on breast cancer cell line (MCF-7) performed by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide assay method. Results: This results study confirmed that the presence of phytochemical composition in the tuber of rodent tuber mutant plants KB 6–1–3–4 and KB 6–9–5 was found six bioactive compounds from fatty acid groups which have the potential as an anticancer compound, such as octadecanoic acid, hexadecanoic acid, hexadecanoic acid methyl ester, 9-octadecanoic acid, linolelaidic acid methyl ester, and butanoic acid. The results showed that extracts from rodent tuber mutant plants had a cytotoxicity effect on MCF-7 cancer cells with half maximal inhibitory concentration (IC50) values that were lower than the control (mother plant). In vitro tests of KB 6–1–3–4 and KB 6–9–5 against MCF-7 cancer cell lines have IC50 values of 12.482 μg/mL and 7.043 μg/mL, respectively, while it had a lower cytotoxicity effect with the IC50 value of control plant was 19.113 μg/mL. The mutant plants of KB 6-9-5 have 3 times more effective than control. Conclusion: The results of this study clearly indicated that rodent tuber mutant plants have shown promising as an anticancer drug on breast cancer.

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“…Some of the other human health problems that may arise due to the ingestion of atropine includes blurred vision, reduced salivation, vasodilation and increased heart rate [155]. It can also be used as an antidote to organophosphorus insecticides [156]. Despite the impressive medicinal value and realization of the detrimental impact of chemical fertilization, few studies focusing on PGPR-Datura interactions have been reported [157,158].…”

Section: Daturamentioning

confidence: 99%

Bioprospecting Plant Growth Promoting Rhizobacteria for Enhancing the Biological Properties and Phytochemical Composition of Medicinally Important Crops

et al. 2022

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Traditionally, medicinal plants have long been used as a natural therapy. Plant-derived extracts or phytochemicals have been exploited as food additives and for curing many health-related ailments. The secondary metabolites produced by many plants have become an integral part of human health and have strengthened the value of plant extracts as herbal medicines. To fulfil the demand of health care systems, food and pharmaceutical industries, interest in the cultivation of precious medicinal plants to harvest bio-active compounds has increased considerably worldwide. To achieve maximum biomass and yield, growers generally apply chemical fertilizers which have detrimental impacts on the growth, development and phytoconstituents of such therapeutically important plants. Application of beneficial rhizosphere microbiota is an alternative strategy to enhance the production of valuable medicinal plants under both conventional and stressed conditions due to its low cost, environmentally friendly behaviour and non-destructive impact on fertility of soil, plants and human health. The microbiological approach improves plant growth by various direct and indirect mechanisms involving the abatement of various abiotic stresses. Given the negative impacts of fertilizers and multiple benefits of microbiological resources, the role of plant growth promoting rhizobacteria (PGPR) in the production of biomass and their impact on the quality of bio-active compounds (phytochemicals) and mitigation of abiotic stress to herbal plants have been described in this review. The PGPR based enhancement in the herbal products has potential for use as a low cost phytomedicine which can be used to improve health care systems.

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Phenylpropanoids and Fatty Acids Levels in Roots and Leaves of Datura Stramonium and Datura Innoxia

Cited by 9 publications

References 24 publications

Comparative Analysis of Morphology and Phytochemical Constituents in Different Populations and Morphotypes of Datura Innoxia Mill. And Datura Metel L. From Punjab Plains

Comparative Analysis of Morphology and Phytochemical Constituents in Different Populations and Morphotypes of Datura Innoxia Mill. And Datura Metel L. From Punjab Plains

In Vitro Cytotoxic Activity of Rodent Tuber Mutant Plant (Typhonium Flagelliforme Lodd.) Against to McF-7 Breast Cancer Cell Line

Bioprospecting Plant Growth Promoting Rhizobacteria for Enhancing the Biological Properties and Phytochemical Composition of Medicinally Important Crops

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