Phenylpropanoid glycosides of Teucrium polium

Oganesyan, G. B.; Galstyan, Anahit; Mnatsakanyan, V. A.; Шашков, А. С.; Agababyan, P. V.

doi:10.1007/bf00630353

Cited by 19 publications

(18 citation statements)

References 5 publications

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“…Earlier Galstyan A.M. et al showed that hydroponic Teucrium polium contains flavonoid, terpenoid, iridoid and phenilpropanoid glycosides, exhibiting high biological activity [21, 22]. The expediency of cultivation of Teucrium polium in open hydroponics, in order to obtain the ecologically clean yield and programmed chemical composition-enrichment by flavonoid glycosides (apigenin, luteolin) and phenolic glycosides (verbascoside, poliumoside, teupolioside) was established [23].…”

Section: Discussionmentioning

confidence: 99%

“…The expediency of cultivation of Teucrium polium in open hydroponics, in order to obtain the ecologically clean yield and programmed chemical composition-enrichment by flavonoid glycosides (apigenin, luteolin) and phenolic glycosides (verbascoside, poliumoside, teupolioside) was established [23]. It was shown that Teucrium polium L (due to its proven AChE inhibitory capacity and antioxidant properties) is a new promising candidate and alternative medicine for treatment or prevention of Alzheimer’s disease and related disorders [24, 25].…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of hydroponic Teucrium polium on hippocampal neurodegeneration in ovariectomized rats

Simonyan

Chavushyan

2016

BMC Complement Altern Med

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BackgroundThe hippocampus is a target of ovarian hormones, and is necessary for memory. Ovarian hormone loss is associated with a progressive reduction in synaptic strength and dendritic spine. Teucrium polium has beneficial effects on learning and memory. However, it remains unknown whether Teucrium polium ameliorates hippocampal cells spike activity and morphological impairments induced by estrogen deficiency.MethodsIn the present study, we investigated the effects of hydroponic Teucrium polium on hippocampal neuronal activity and morpho-histochemistry of bilateral ovariectomized (OVX) rats. Tetanic potentiation or depression with posttetanic potentiation and depression was recorded extracellularly in response to ipsilateral entorhinal cortex high frequency stimulation. In morpho-histochemical study revealing of the activity of Ca2+-dependent acid phosphatase was observed. In all groups (sham-operated, sham + Teucrium polium, OVX, OVX + Teucrium polium), most recorded hippocampal neurons at HFS of entorhinal cortex showed TD-PTP responses.ResultsAfter 8 weeks in OVX group an anomalous evoked spike activity was detected (a high percentage of typical areactive units). In OVX + Teucrium polium group a synaptic activity was revealed, indicating prevention OVX-induced degenerative alterations: balance of types of responses was close to norm and areactive units were not recorded. All recorded neurons in sham + Teucrium polium group were characterized by the highest mean frequency background and poststimulus activity. In OVX+ Teucrium polium group the hippocampal cells had recovered their size and shape in CA1 and CA3 field compared with OVX group where hippocampal cells were characterized by a sharp drop in phosphatase activity and there was a complete lack of processes reaction.ConclusionThus, Teucrium polium reduced OVX-induce neurodegenerative alterations in entorhinal cortex-hippocamp circuitry and facilitated neuronal survival by modulating activity of neurotransmitters and network plasticity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Protective effects of hydroponic Teucrium polium on hippocampal neurodegeneration in ovariectomized rats

Simonyan

Chavushyan

2016

BMC Complement Altern Med

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“…Infusion of the leaves and flowers is consumed as a appetite stimulating beverage. Some biological and therapeutic effects have been reported for the plant such as anti-oxidant (Kadifkova Panovska et al, 2005;Ardestani et al, 2008;Esmaeili et al, 2009), anti-inflammatory (Tariq et al, 1989;Capasso et al, 1983), anti-nociceptive (Baluchnejadmojarad et al, 2005;Abdollahi et al, 2003), anti-pyretic (Autore et al, 1984), antimicrobial (Autore et al, 1984;Zerroug et al, 2011), hypolipidemic (Rasekh et al, 2001, Esmaeili andYazdanparast, 2004;Stefkov et al, 2011), hepatoprotective (Panovska et al, 2007), cytotoxic and apoptotic effects (Rajabalian et al, 2008). It is also found that protects against ethanolinduced gastric mucosal damage (Mashreghi and Niknia, 2012).…”

Section: Introductionmentioning

confidence: 99%

HPLC and UV-spectrophotometry analysis of flavonoids in spray-dried and freez-dried extracts of Teucrium polium L. (Lamiaceae)

Stefkov¹,

Karapandzova²,

Стефова³

et al. 2012

Maced. Pharm. Bull.

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Тhe aim of the study was identification and determination of the content of flavonoids in dry extracts of Teucrium polium, collected from Republic of Macedonia. Two different drying procedures were used, freeze and spray draying. In freeze-dried (FDE) and spray-dried (SDE) extracts of aerial parts of T. polium five flavone aglycones (luteolin, apigenin, cirsiliol, cirsimaritin and cirsilineol) were identified by HPLC method, on the base of retention times and UV spectral data of the components of the extracts in comparison to the authentic samples of flavonoids. Additionally, seven glycosides of apigenin and luteolin were tentatively identified. No significant differences in the composition nor in the content of identified flavonoids were found between both extracts. The content of total flavonoids determined by UV-spectrophotometry with AlCl3 was 72.8 ± 0.62 mg Lut/g and 73.34 ± 0.53 mg Lut/g in FDE and SDE extract of T. polium, respectively.

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“…Some biological and therapeutic effects have been reported for the plant such as antioxidant (Esmaeili et al, 2009;Ardestani et al, 2008), antiinflammatory (Tariq et al, 1989;Capasso et al, 1983), antinociceptive (Baluchnejadmojarad et al, 2005;Abdollahi et al, 2003), antipyretic (Aggelis et al, 1998;Autore et al, 1984), anti-microbial (Autore et al, 1984), hypolipidemic (Rasekh et al, 2001), hepatopro-tective (Panovska et al, 2007), cytotoxic and apoptotic effects (Rajabalian et al, 2008). The plant poses complex chemical composition with presence of new clerodane type diterpenes (Malakov and Papanov, 1983;Marquez and Valverde, 1979), essential oil with dominating sesquiterpene alcohols and pinenes (Cozzani et al, 2005;Moghtader, 2009;Kabouche et al, 2007), phenylethanoid glycosides such as verbascoside and poliumoside (Oganesyan et al,1991), flavone glycosides with highly methylated aglycons (Verykokidou-Vitsaropoulou and Vajias, 1986;Rizk et al, 1986;Kawashty et al, 1999;Harborne et al, 1986;Sharififar et al, 2009), etc. Flavonoids are representing the most important group of active components of Teucrium species, and many of the activities of these plants are attributed to the flavonoid class of secondary metabolites. It is also well known that the composition and the content of the flavonoids in plant material could be variable depending of the season, location and environmental condition of plant growth as well as the influence of other different factors (Liu et al, 1994;De Castro, et al, 2006;Bagdonaite et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Seasonal variation of flavonoids in Teucrium polium L. (Lamiaceae)

Stefkov¹,

Karapandzova²,

Стефова³

et al. 2009

Maced. Pharm. Bull.

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Тhe aim of the present study was identification of flavone aglycones and determination of the content of each and the content of total flavonoids as well as investigation of the eventual seasonal variations of flavonoids in Teucrium polium L. (Lamiaceae). The plant samples were collected at six different locations in Republic of Macedonia, during summer in 1999, 2000 and 2003. For determination of seasonal variations, the samples were collected in v. Koleshino, in 2004, each month during the whole season. Six flavone aglycones (luteolin, apigenin, diosmetin, cirsiliol, cirsimaritin and cirsilineol) were identified in the hydrolyzed extracts of the over ground part of Teucrium polium by HPLC method. The most abundant flavone was luteolin, followed by apigenin and cirsimaritin. Great seasonal variations were found in the content of each and in the content of total amount of flavonoids. The most abundant flavone during the whole season was luteolin with the highest content in May. The content of total flavonids was the highest in the period from May to July, which could be recommended as the most convenience period in the season for collecting of the plant material from Teucrium polium.

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Phenylpropanoid glycosides of Teucrium polium

Cited by 19 publications

References 5 publications

Protective effects of hydroponic Teucrium polium on hippocampal neurodegeneration in ovariectomized rats

Protective effects of hydroponic Teucrium polium on hippocampal neurodegeneration in ovariectomized rats

HPLC and UV-spectrophotometry analysis of flavonoids in spray-dried and freez-dried extracts of Teucrium polium L. (Lamiaceae)

Seasonal variation of flavonoids in Teucrium polium L. (Lamiaceae)

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