Phenylketonuria in an adult with normal diet

Balaji, Kanmani; Narayan, Manoj; Bradbury, Sarah; Michael, Dasari

doi:10.1002/pnp.417

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Background : PKU is a genetic metabolic disorder in which the body lacks a liver enzyme (phenylalanine hydroxlase) needed to process phenylalanine, an essential amino acid, into another amino acid (tyrosine) used by the body [7]. Left unconverted, excessive amounts of phenylalanine in the bloodstream are toxic to brain tissue and the central nervous system; if untreated in newborns, PKU can cause brain damage and mental retardation.…”

Section: On His Own In Addition He Is Unable To Control Urination Anmentioning

confidence: 99%

Problem based learning (PBL) in Organic Chemistry

Alobaidi

2018

IJMS

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Background: PBL appears to answer many concerns regarding educational methods, encourages students to look for new solutions to relevant problems using available knowledge and resources. The process expands students' critical thinking and problem solving skills while enhancing their creative capabilities Objective: To develop a PBL modules for teaching of organic chemistry. Methods: This module was developed for implementation in the curriculum of Chemistry Departments in Colleges of Sciences and Education. This is an innovations to be developed for increasing the wide-ranging abilities of students. A series of strategies which are involved in PBL, concept mapping and online communications, are suggested and discussed in terms of encouraging student-centered learning.

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Section: On His Own In Addition He Is Unable To Control Urination Anmentioning

confidence: 99%

Problem based learning (PBL) in Organic Chemistry

Alobaidi

2018

IJMS

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Multisegment Injection–Capillary Electrophoresis–Mass Spectrometry: A Robust Platform for High Throughput Metabolite Profiling with Quality Assurance

Britz‐McKibbin

2018

Capillary Electrophoresis – Mass Spectrometry for Metabolomics

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Capillary electrophoresis–mass spectrometry (CE-MS) is a high efficiency separation platform for metabolomic studies that is ideal for the analysis of volume-restricted biological specimens. However, major technical hurdles prevent more widespread use of CE-MS technology, including poor method robustness that is supported by long-term validation studies. We outline efforts towards developing a more robust CE-MS method that offers significant improvements in sample throughput and data fidelity as required for large-scale clinical and epidemiological studies. In this chapter, multisegment injection (MSI)-CE-MS is demonstrated as a multiplexed separation platform for high throughput metabolite profiling in various biological samples with quality assurance. Careful attention to capillary preparation while using standardized operating protocols is critical for successful operations, including rigorous inter-method comparisons and batch-correction algorithms to adjust for system drift. MSI-CE-MS offers a versatile platform using serial injection formats for temporal encoding of mass spectral data, which allows for unambiguous identification and reliable quantification of both polar and non-polar ionic metabolites of clinical significance. Recent data workflows for accelerating biomarker discovery will be discussed, including new advances in population-based screening for early detection of in-born errors of metabolism, validation of lifestyle intervention studies that promote human health and comprehensive drug surveillance given the worldwide opioid crisis.

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Phenylketonuria in an adult with normal diet

Cited by 2 publications

References 3 publications

Problem based learning (PBL) in Organic Chemistry

Problem based learning (PBL) in Organic Chemistry

Multisegment Injection–Capillary Electrophoresis–Mass Spectrometry: A Robust Platform for High Throughput Metabolite Profiling with Quality Assurance

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