Abstract:Capillary electrophoresis–mass spectrometry (CE-MS) is a high efficiency separation platform for metabolomic studies that is ideal for the analysis of volume-restricted biological specimens. However, major technical hurdles prevent more widespread use of CE-MS technology, including poor method robustness that is supported by long-term validation studies. We outline efforts towards developing a more robust CE-MS method that offers significant improvements in sample throughput and data fidelity as required for l… Show more
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